Physicochemical, spectroscopic and tableting properties of microcrystalline cellulose obtained from the African breadfruit seed hulls

Abstract

This study evaluates the physicochemical, tableting and spectroscopic properties of microcrystalline cellulose obtained from the African breadfruit seed hulls. The seed hulls were dried, pulverized, sieved and digested with 2% w/v aqueous sodium hydroxide solution. The resultant pulp was further treated with 17.5% w/v NaOH solution and 2.5N hydrochloric acid to produce α-cellulose and microcrystalline cellulose (BH-MCC), respectively. The prepared BH-MCC was characterized by studying their functional groups (using FT-IR), thermal stability using (TGA) and crystallinity index using (XRD). The results showed the composition of cellulose, hemicelluloses and lignin contents of the seed hulls were 39, 38 and 17%, respectively. The percentage yields of the isolated α-cellulose and BH-MCC were 15.5 and 86.8%, respectively. The bulk, tapped and true densities were 0.33, 0.50 and 1.57 g/ml, respectively. Moisture content, angle of repose and swelling index were 5.3%, 28° and 29%, respectively. Tablets were produced by direct compression using BH-MCC and their analyses showed that the weight uniformity, hardness test, friability and disintegration time values were 190.3±4.2%, 4.95±0.83 kg/cm 2 , 0.04% and 31 s, respectively. The BH-MCC's tablets showed good compliance with the British Pharmacopeia (BP) specification, and can thus be considered useful as a binder and disintegrant in drug formulation.

Extraction and Characterization of Pharmaceutical Grade Microcrystalline Cellulose From Bambara Nut (Voandzeia Subterranean (L) Thousars) Husk

“…BNS -MCC recorded a compressibility index of 25.75 % while the angle of repose recorded 39.80 o . The values of both Hausner's and Carr's indices and angle of repose shows that BNS -MCC flowed poorly according to the flowability scale in Table 3, but had better flow [35], CP -MCC (1.65, 39.5) [19] respectively. However, a glidant will be required to improve the flowability when using BNS-MCC in solid dosage forms formulations.…”