Physicochemical properties of quinolone antibiotics in various environments

Park, Hyoung‐Ryun; Kim, Tae Heung; Bark, Ki‐Min

doi:10.1016/s0223-5234(02)01361-2

Cited by 167 publications

(97 citation statements)

References 94 publications

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“…Th e experimental parameters for a better resolution are buff er type and concentration, pH, organic modifi er and voltage [11][12][13][14]. Norfl oxacin and ciprofl oxacin both have two relevant ionizable functional groups, the 3-carboxyl group and N-4 of the piperazine ring, which determine their acid-base properties [5]. According to Barbosa et al [15] who have studied the eff ect of pH on electrophoretic behaviour of various quinolones, when pH values are comprised between pK1 and pK2 the major form is the zwitterionic one, so quinolones migrate with electroosmotic fl ow and electrophoretic mobility values are nil.…”

Section: Discussionmentioning

confidence: 99%

“…Fluoroquinolones (FQs) are synthetic antibacterial agents with a broad spectrum of activity. Th e second generation fl uoroquinolones, which are the focus of this review have a 6-fl uoro substituent on the quinolone ring structure, responsible for their broad gram negative activity and a 7-piperazinyl substituent, the last providing them a longer half-life [4][5][6]. Guest-host interactions of two quinolones, ciprofl oxacin and norfl oxacin with four cyclodextrins, beta-cyclodextrin (-CD), gamma-cyclodextrin (-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP--CD) and randomly methylated beta-cyclodextrin (RAMEB), were tested and their separation was achieved by capillary electrophoresis.…”

Section: Introductionmentioning

confidence: 99%

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Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis

Székely-Szentmiklósi

Tőkés

2013

Acta Medica Marisiensis

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Introduction:In the present work we evaluated the complexation role of cyclodextrins toward fl uoroquinolones in an attempt to assess their potential as new formulation additives for more effi cient fl uoroquinolone delivery and as selectors in capillary electrophoresis. Material and method: Guest-host interactions of two second generation quinolones, ciprofl oxacin and norfl oxacin with four cyclodextrins, beta-cyclodextrin (-CD), gamma-cyclodextrin (-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP--CD) and randomly methylated beta-cyclodextrin (RAMEB), were tested by capillary electrophoresis in borate running buffer. Experimental parameters like buffer concentration, pH, organic modifi er, voltage and cyclodextrin concentration have been varied for a better resolution. Results: In capillary zone electrophoresis ciprofl oxacin and norfl oxacin are migrating together, a difference in their migration times and thus separation occured by the addition of cyclodextrins. Conclusion: Our results suggest formation of inclusion complexes between fl uoroquinolones and cyclodextrins. Differences in their affi nity to host molecules resulted in separation of the two fl uoroquinolones.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis

Székely-Szentmiklósi

Tőkés

2013

Acta Medica Marisiensis

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“…The composition of the quinolone complex was reported to be 1:1 for Mn, Zn, Co, and Ni cations, with the apparent complex constant log K f values in the range of 3.3À4.6. 15 Results of Wallis et al 16 showed that the addition of CIP to Cu formed CuCIP and Cu(CIP) 2 complexes in a stepwise manner, and their formation constants were log K 1 = 6.2 and log K 2 = 11.1. The crystal of the Cd and CIP complex was synthesized, and both 1:1 and 1:2 complexes were formed between Cd and CIP.…”

Section: Possibility Of Cdàcip Complex Formation In Solutionmentioning

confidence: 99%

Effect of Complexation on the Accumulation and Elimination Kinetics of Cadmium and Ciprofloxacin in the Earthworm Eisenia fetida

Wen

Huang

Wang

et al. 2011

Environ. Sci. Technol.

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Land application of solid wastes leads to the accumulation of both metals and antimicrobials in soils. To understand the effects of metal and antibiotic interaction on their accumulation by the earthworm Eisenia fetida, uptake and elimination kinetics and subcellular distribution of cadmium (Cd) and ciprofloxacin (CIP) were determined. The kinetics was accurately described by a one-compartment first-order kinetic model. Bioaccumulation kinetics and subcellular distribution of CIP were not affected by Cd addition. However, Cd exhibited different metabolic and subcellular distribution patterns. With CIP, Cd uptake flux and elimination rate constants were about 2.2 and 9.8 times, respectively, those without CIP. In the presence of CIP, Cd redistributed from fractions D (associated with granules) and E (associated with tissue fragments and cell membranes) to fraction C (associated with cytosol). Without CIP, Cd in fraction C could not be excreted, whereas with CIP, Cd in fraction C was significantly excreted, and the excretion rate constant was consistent with that of CIP. A good relationship was found between CIP and Cd in earthworms during uptake and elimination periods (p < 0.01). Our results indicated that the CdÀCIP complex may be taken up, stored, and eliminated by earthworms.

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“…The species of organic contaminants and their solubility and mobility differ in different organic solvents or cosolvents (Park et al, 2002). Cosolvents have been noted to increase organic contaminant solubility.…”

Section: Water-organic Cosolventsmentioning

confidence: 99%

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Peng

Zhang

et al. 2014

J. Zhejiang Univ. Sci. A

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Carbon nanoparticles (CNPs) are novel manufactured materials with unique properties and have potential for a variety of applications. Adsorption of organic contaminants by discharged CNPs may affect the fate and transport of organic contaminants in the environment. This review summarizes the present research progress regarding organic contaminant adsorption on CNPs, and provides important information for the evaluation of the environmental behavior of organic contaminants and the risks associated with the use of CNPs. The main adsorption mechanisms involve hydrophobic interactions, π-π interactions, hydrogen bonds, and electrostatic interactions. These interactions may exist simultaneously, while the controlling adsorption mechanism differs depending on the properties of both the organic contaminants and the CNPs along with environmental conditions. The status of CNPs in the environment greatly affects or even controls their characteristics for adsorption of organic contaminants. The mobility and transport of dispersed CNPs and CNP-adsorbed organic contaminants could be promoted in natural aqueous environments, potentially increasing the spread of various organic contaminants and their associated environmental risks. Investigating the adsorption mechanisms and impact parameters is vital in predicting the environmental behaviors of both organic contaminants and CNPs and their associated risks.

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Physicochemical properties of quinolone antibiotics in various environments

Cited by 167 publications

References 94 publications

Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis

Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis

Effect of Complexation on the Accumulation and Elimination Kinetics of Cadmium and Ciprofloxacin in the Earthworm Eisenia fetida

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

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