Physicochemical Properties of Minerals Relevant to Biological Activities: State of the Art

Langer, Arthur M.; Nolan, Robert P.

doi:10.1007/978-3-642-70630-1_2

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…The interactions supposedly result in conformational changes of the PL bilayer, ultimately leading to disruption of the membrane. In the case of quartz, the interaction is supposed to involve electrostatic forces between the positively charged quaternary ammonium moeity of the PL's head group and the negatively charged surface sites (23)(24)(25). A variant of this idea invokes H-bonding interactions between charge-neutral silanol surface sites (>SiOH) and the negatively charged -PO − 4 moeity of the PL head group or negatively charged membrane proteins (26)(27)(28).…”

Section: Background Informationmentioning

confidence: 97%

Biomembrane Phospholipid–Oxide Surface Interactions: Crystal Chemical and Thermodynamic Basis

Sahai

2002

Journal of Colloid and Interface Science

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Section: Background Informationmentioning

confidence: 97%

Biomembrane Phospholipid–Oxide Surface Interactions: Crystal Chemical and Thermodynamic Basis

Sahai

2002

Journal of Colloid and Interface Science

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“…A typical example is the variety of biological responses to the simple compound, silicon dioxide (1)(2)(3)(6)(7)(8)(9)18). The various crystalline silica polymorphs exhibit remarkable differences in their pathogenic potential related to differences in crystal structure (1,3,8,(19)(20)(21). Even specimens of the same silica polymorph, e.g., cristobalite dusts of different origin (22,23) (22,33).…”

Section: Physicochemical Factors Influencing Surface Reactivitymentioning

confidence: 99%

“…Attention was then focused on the crystal faces exposed and on the chemical functionalities present at the surface (7)(8)(9). Few extensive reviews on the physicochemical properties of minerals relevant to biological activities appeared in the subsequent years (8)(9)(10); meanwhile, research proceeded much more on the biomedical…”

Section: Introductionmentioning

confidence: 99%

Surface reactivity in the pathogenic response to particulates.

Fubini

1997

Environ Health Perspect

121

100

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The peculiar characteristics of dust toxicity are discussed in relation to the processes taking place at the particle-biological medium interface. Because of surface reactivity, toxicity of solids is not merely predictable from chemical composition and molecular structure, as with water soluble compounds. With particles having the same bulk composition, micromorphology (the thermal and mechanical history of dust and adsorption from the environment) determines the kind and abundance of active surface sites, thus modulating reactivity toward cells and tissues. The quantitative evaluation of doses is discussed in comparisons of dose-response relationships obtained with different materials. Responses related to the surface of the particle are better compared on a per-unit surface than per-unit weight basis. The role of micromorphology, hydrophilicity, and reactive surface cations in determining the pathogenicity of inhaled particles is described with reference to silica and asbestos toxicity. Heating crystalline silica decreases hydrophilicity, with consequent modifications in membranolytic potential, retention, and transport. Transition metal ions exposed at the surface generate free radicals in aqueous suspensions. Continuous redox cycling of iron, with consequent activation-reactivation of the surface sites releasing free radicals, could account for the long-term pathogenicity caused by the inhalation of iron-containing fibers. In various pathogenicities caused by mixed dusts, the contact between components modifies toxicity. Hard metal lung disease is caused by exposure to mixtures of metals and carbides, typically cobalt (Co) and tungsten carbide (WC), but not to single components. Toxicity stems from reactive oxygen species generation in a mechanism involving both Co metal and WC in mutual contact. A relationship between the extent of water adsorption and biopersistence is proposed for vitreous fibers. Modifications of the surface taking place in vivo are described for ferruginous bodies and for the progressive comminution of chrysotile asbestos fibers. Environ Health Perspect 1 05(Suppl 5): 1013-1020 (1997)

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“…The encapsulation of proteins in silica nanoparticles would provide particles much larger than 3 nm. Langer and Nolan (10) proposed that proton-donating silanols facilitate the attachment of silica to the cell membrane, whereas a negative charge supplied by ionized silanol is critical to lytic activity.…”

Section: Introductionmentioning

confidence: 99%