Inorganic–Organic Hybrid Nanoparticles from n-Octyl Triethoxy Silane

Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain

“…ORMOSIL nanoparticles are prepared from oil-in-water microemulsions, avoiding corrosive solvents such as cyclohexane, and through a complex purification process. Their organic groups can be further modified for the attachment of targeting molecules and can be possibly biodegraded through the biochemical decomposition of the silicon-carbon bond (11,12). The presence of this organic group also imparts some degree of flexibility to the otherwise rigid silica matrix, which enhances the stability of such particles in aqueous systems.…”

Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery

“…However, ORMOSILs, which have a mesoporous structure by virtue of the presence of organic moieties, have been reported to at least partially release encapsulated dyes (13,22). We investigated the release kinetics of two types of ORMOSIL-encapsulated dyes having similar molecular weights, an amphiphilic dye (Rh6G) and a hydrophobic dye (HPPH), in an aqueous buffer system at 37°C as shown in Fig.…”

“…The resulting micellar (and reverse micellar) cores can be loaded with biomolecules such as drugs, proteins, etc. (13,14). Such a system has a number of advantages.…”

“…(i) They can be loaded with either hydrophilic or hydrophobic drugs͞dyes; (ii) they can be precipitated in oil-in-water microemulsions in which corrosive solvents such as cyclohexane and complex purification steps such as solvent evaporation, ultracentrifugation, etc. can be avoided; (iii) their organic groups can be modified further for attachment of targeting molecules; and (iv) they can be possibly biodegraded through the biochemical decomposition of the SiOC bond (13). The presence of the organic group also imparts some degree of flexibility to the otherwise rigid silica matrix, which is expected to enhance the stability of such particles in aqueous systems against precipitation.…”

Microemulsion Route for the Synthesis of Nano-Structured Catalytic Materials

“…Microemulsions are a subject of extensive research due to their wide range of applications in several fields, including cosmetics [13], lubricants [14], as pesticides in agrochemicals [14,15], textile industry as finishing and dyeing materials, electrocatalytic, organic and photochemical reactions [16,17], liquid membranes, fuels, detoxification of environment [18,19], pharmaceutical industry [15,20,21], corrosion inhibitors [14], detergents [2], as oil flavors in the food industry [2,22], bio-separation [23], oil recovery [24], etc. Nanoparticles having unique properties, finding their potential use in homogeneous and heterogeneous electrocatalysis, fluorescence probes, thermoelectric transport, bioassays, optical nanosensors, biotechnology, bio-imaging, aerosols, etc.…”