Physicochemical properties of enrofloxacin

Lizondo, Mònica; Pons, Miquel; Gallardo, Montserrat; Estelrich, Joan

doi:10.1016/s0731-7085(96)02033-x

Cited by 90 publications

(69 citation statements)

References 6 publications

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“…Above this pH, ENF is negatively charged and shows hydrophilic properties. Nearly all quinolones show hydrophobic properties that depend on structure and pH (Lizondo et al 1997). ENF has encapsulated negative charge in MLVs suspension (pH∼7.5), and the addition of DCP (negatively charged) into liposome formulation increased this negativity and decreased the encapsulation capacity to 57.9% as seen in Table 1.…”

Section: Characterization Of Enf Liposomesmentioning

confidence: 99%

“…Therefore ENF does not concentrate effectively in the cell pathogens and this problem affects the therapeutic efficiency of free ENF. It has been pointed out that encapsulations of fluoroquinolones in liposomes could improve their effectiveness in cells (Montero et al 1994;Puglisi et al 1995;Cabanes et al 1995;Lizondo et al 1997;Baş et al 2000). However, there is limited information on liposomal form of ENF (Cabanes et al 1995;Baş et al 2000Baş et al , 2002Sezer et al 2002Sezer et al , 2004.…”

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confidence: 99%

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In Vitro Evaluation of Enrofloxacin-Loaded MLV Liposomes

2007

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Section: Characterization Of Enf Liposomesmentioning

confidence: 99%

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confidence: 99%

In Vitro Evaluation of Enrofloxacin-Loaded MLV Liposomes

2007

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“…The octanol-aqueous buffer pH 7.0 partition coefficient for enrofloxacin is 3.48. Therefore, this drug is considered highly lipophilic (18). According to Seedher (19), enrofloxacin water solubility is 146 mg/mL, and it is listed as poorly soluble based on pharmacopeial criteria.…”

Section: Solubility Determination and Sink Conditionsmentioning

confidence: 99%

An Alternative Method for the Dissolution of Enrofloxacin Tablets

Foresti¹,

Becker²,

Silva³

et al. 2015

Dissolution Technol.

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Enrofloxacin is a fluoroquinolone for veterinary use; it has low aqueous solubility and relatively high permeability. Dissolution may be the limiting step in absorption for solid dosage forms having these characteristics. Considering this, in vitro dissolution tests are indicated to evaluate batch-to-batch quality and to support pharmaceutical equivalence studies. In this study, an alternative dissolution profile was developed for tablets containing enrofloxacin. The selected method uses a 0.01 N HCl medium, paddle apparatus, and 50-rpm speed. The samples were analyzed by UV spectroscopy at 273 nm. The results confirm that the proposed method is suitable for routine quality control of enrofloxacin tablets and the comparison of the dissolution profiles of different commercial formulations.

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“…Depending on the pH, it can exist in four forms: cationic (C), neutral non-ionized (N), zwitterionic (Z) and anionic (A) (Fig. 1) [28,29]. In strong acidic conditions, only the 7-piperazinyl group is positively charged, while in strongly basic medium, only the 3-carboxylic group is negatively charged.…”

Section: Effect Of Phmentioning

confidence: 99%

Ciprofloxacin-imprinted polymeric receptors as ionophores for potentiometric transduction

Oliveira

Moreira

Sales

2011

Electrochimica Acta

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A 3D-mirror synthetic receptor for ciprofloxacin host-guest interactions and potentiometric transduc-tion is presented. The host cavity was shaped on a polymeric surface assembled with methacrylic acid or 2-vinyl pyridine monomers by radical polymerization. Molecularly imprinted particles were dis-persed in 2-nitrophenyl octyl ether and entrapped in a poly(vinyl chloride) matrix. The sensors exhibited a near-Nernstian response in steady state evaluations. Slopes and detection limits ranged from 26.8 to 50.0 mV decade −1 and 1.0 × 10 −5 to 2.7 × 10 −5 mol L −1 , respectively. Good selectivity was observed for trimethoprim, enrofloxacin, tetracycline, cysteine, galactose, hydroxylamine, creatinine, ammonium chloride, sucrose, glucose, sulphamerazine and sulfadiazine. The sensors were successfully applied to the determination of ciprofloxacin concentrations in fish and in pharmaceuticals. The method presented offered the advantages of simplicity, accuracy, applicability to colored and turbid samples and automa-tion feasibility, as well as confirming the use of molecularly imprinted polymers as ionophores for organic ion recognition in potentiometric transduction.

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Physicochemical properties of enrofloxacin

Cited by 90 publications

References 6 publications

In Vitro Evaluation of Enrofloxacin-Loaded MLV Liposomes

In Vitro Evaluation of Enrofloxacin-Loaded MLV Liposomes

An Alternative Method for the Dissolution of Enrofloxacin Tablets

Ciprofloxacin-imprinted polymeric receptors as ionophores for potentiometric transduction

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