Physicochemical properties of enhanced-fluidity liquid solvents

Olesik, Susan V.

doi:10.1016/j.chroma.2004.04.001

Cited by 27 publications

(15 citation statements)

References 18 publications

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“…Other authors have also recommended the use of high modifiers concentrations (25-50%), which are not normally used in SFC, to achieve similar elution behavior for high polarity compounds in comparison to those obtained in RPLC. This type of SFC is called as enhanced fluidity chromatography [38].…”

Section: Gradient Elution Modementioning

confidence: 99%

Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Férnandez-Ponce

Casas

Ossa

2014

The Journal of Supercritical Fluids

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Section: Gradient Elution Modementioning

confidence: 99%

Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Férnandez-Ponce

Casas

Ossa

2014

The Journal of Supercritical Fluids

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“…Furthermore, these improvements are also typically gained without substantial loss of polarity from the mobile phase [13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced fluidity liquid chromatography for hydrophilic interaction separation of nucleosides

Treadway

Philibert

Olesik

2011

Journal of Chromatography A

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“…This often leads to improved chromatographic performance in terms of efficiency, resolution, and separation time. Additionally, these improvements are gained without significant loss of polarity from the original mobile phase , which allows for analysis of highly polar or ionic compounds. Thus, by combining conventional SubFC with EFLC, the entire solvent range from 0–100% organic solvent is spanned.…”

Section: Introductionmentioning

confidence: 99%

Enhanced‐fluidity liquid chromatography using mixed‐mode hydrophilic interaction liquid chromatography/strong cation‐exchange retention mechanisms

Beres

Olesik

2015

J of Separation Science

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The potential of enhanced-fluidity liquid chromatography, a subcritical chromatography technique, in mixed-mode hydrophilic interaction/strong cation-exchange separations is explored, using amino acids as analytes. The enhanced-fluidity liquid mobile phases were prepared by adding liquefied CO to methanol/water mixtures, which increases the diffusivity and decreases the viscosity of the mixture. The addition of CO to methanol/water mixtures resulted in increased retention of the more polar amino acids. The "optimized" chromatographic performance (achieving baseline resolution of all amino acids in the shortest amount of time) of these methanol/water/CO mixtures was compared to traditional acetonitrile/water and methanol/water liquid chromatography mobile phases. Methanol/water/CO mixtures offered higher efficiencies and resolution of the ten amino acids relative to the methanol/water mobile phase, and decreased the required isocratic separation time by a factor of two relative to the acetonitrile/water mobile phase. Large differences in selectivity were also observed between the enhanced-fluidity and traditional liquid mobile phases. A retention mechanism study was completed, that revealed the enhanced-fluidity mobile phase separation was governed by a mixed-mode retention mechanism of hydrophilic interaction/strong cation-exchange. On the other hand, separations with acetonitrile/water and methanol/water mobile phases were strongly governed by only one retention mechanism, either hydrophilic interaction or strong cation exchange, respectively.

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Physicochemical properties of enhanced-fluidity liquid solvents

Cited by 27 publications

References 18 publications

Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Enhanced fluidity liquid chromatography for hydrophilic interaction separation of nucleosides

Enhanced‐fluidity liquid chromatography using mixed‐mode hydrophilic interaction liquid chromatography/strong cation‐exchange retention mechanisms

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