Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Férnandez-Ponce, M.T.; Casas, Lourdes; Ossa, Enrique Martínez de la

doi:10.1016/j.supflu.2014.10.005

Cited by 14 publications

(2 citation statements)

References 39 publications

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“…Totals of 24 and 30 compounds were characterized by GC‐QTOF and LC‐QTOF analyses, respectively (Table 5), and total ion current base peak chromatograms ae shown in the supporting information (Figs S1 and S2). Gallic acid was frequently reported previously from M. indica seed, 72 seed kernel, 43 ripe seed, 1 kernels, 73 fruit, 44 ripe peel, 74 peel, 15,40 peel and seed, 75 peel and flesh, 76 pulp and peel, 42 pulp, 77 bark, 78,79 leaf 47,48,80,81 and mango wine 44 (supporting information, Table S1).…”

Section: Resultsmentioning

confidence: 57%

Untargeted metabolomics‐based identification of bioactive compounds from Mangifera indica L. seed extracts in drug discovery through molecular docking and assessment of their anticancer potential

Kaneria,

Rakholiya,

Bavaliya

et al. 2024

J Sci Food Agric

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BackgroundMangifera indica L. (mango), a medicinal plant rich in biologically active compounds have potential to be used in disease‐preventing and health‐promoting products. The present investigation reveals and uncovers bioactive metabolites with remarkable therapeutic efficiency from mango (Family: Anacardiaceae) seeds.ResultsBiological activity was determined by antimicrobial, antioxidant, and anticancer assays, and metabolite profiling was performed on the gas chromatography coupled to quadrupole time‐of‐flight mass spectrometry (GC‐QTOF‐MS) and liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS) platforms. Validation of active metabolites was carried out by in silico molecular docking (Molinspiration Cheminformatics Server and PASS). Extracted and identified metabolites were screened; 54 compounds associated with various groups were selected for the in silico interaction study.ConclusionsMolecular docking revealed lead molecules with a potential binding energy score, its efficacy and stable modulation with a selected protein domain. Investigation, directed by in vitro and in silico analysis, confirms mango seeds as an excellent source of potential metabolites as a therapeutic agent.This article is protected by copyright. All rights reserved.

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Section: Resultsmentioning

confidence: 57%

Untargeted metabolomics‐based identification of bioactive compounds from Mangifera indica L. seed extracts in drug discovery through molecular docking and assessment of their anticancer potential

Kaneria,

Rakholiya,

Bavaliya

et al. 2024

J Sci Food Agric

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“…Mango leaves ethanolic extracts presented the highest antioxidant activity, followed by red grape pomace and olive leaves (Figure 1C,D). Full information regarding the characteristics of the extracts (polyphenolic and anthocyanin content, antioxidant activity) as well as the extraction techniques can be found in previous works [17,19,31,32].…”

Section: Chemical and Functional Characterization Of Extracts Obtaine...mentioning

confidence: 99%

Pro-Angiogenic Effects of Natural Antioxidants Extracted from Mango Leaf, Olive Leaf and Red Grape Pomace over Endothelial Colony-Forming Cells

et al. 2022

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Cardiovascular diseases remain the leading cause of death worldwide, mainly triggered by the formation of atherosclerotic plaques that reduce blood flow. Angiogenic cell therapy based on endothelial colony forming cells (ECFCs) constitutes a promising alternative to promote vascular revascularization; however, under the oxidative environment that prevails in ischemic areas, these cells become impaired. Thus, it is necessary to investigate strategies to enhance their regenerative properties. Antioxidant substances, such as polyphenols, have been shown to be useful for this purpose. In the current study we evaluated the potential of mango leaves, olive leaves and red grape pomace extracts, rich in polyphenols, to promote ECFC reparative effects. For this, aqueous and ethanolic extracts of the aforementioned raw materials were obtained by pressurized liquid extraction (PLE). After evaluating the polyphenol content and the antioxidant activity, in vitro assays were carried out, and we found that ethanolic extracts at low concentrations improved angiogenic capacities of ECFCs and reduced proliferation, apoptosis, and the inflammatory response of these cells. Overall, mango leaves ethanolic extract provided the most promising results, but all three extracts ameliorated the functionality of ECFCs.

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Current trends in supercritical fluid chromatography

West

2018

Anal Bioanal Chem

167

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Supercritical fluid chromatography (SFC), which employs pressurized carbon dioxide as the major component of the mobile phase, has been known for several decades but has faced a significant resurgence of interest in the recent years, thanks to the development of modern instruments to comply with current expectations in terms of robustness and sensitivity. This review is focused on the recent literature, specifically since the introduction of modern systems but in relation to older literature, to identify the changing trends in application domains. Typically, natural products, bioanalysis, food science, and environmental analyses are all strongly increasing. Together with reduced extra-column volumes in the instruments, the advent of sub-2-μm particles and superficially porous particles in the stationary phases is favoring ultra-high-performance SFC (UHPSFC) allowing for improved resolution and faster analyses, but without the constraints of viscous liquids encountered in ultra-high-performance liquid chromatography (UHPLC). Hyphenation to mass spectrometry is also more frequent and opened the way to new application domains, and raises different issues from liquid chromatography mobile phases, especially due to decompression of carbon dioxide. It is also shown that the frontiers between SFC and HPLC are fading, as switching from one method to the other, even within the course of a single analysis, is facilitated my modern instruments. The present review is not intended to be exhaustive but rather giving a snapshot of recent trends in supercritical fluid chromatography, based on the observation of about 500 papers published in English-written peer-reviewed journals from 2014 to 2018. Graphical abstract ᅟ.

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Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale

Cited by 14 publications

References 39 publications

Untargeted metabolomics‐based identification of bioactive compounds from Mangifera indica L. seed extracts in drug discovery through molecular docking and assessment of their anticancer potential

Untargeted metabolomics‐based identification of bioactive compounds from Mangifera indica L. seed extracts in drug discovery through molecular docking and assessment of their anticancer potential

Pro-Angiogenic Effects of Natural Antioxidants Extracted from Mango Leaf, Olive Leaf and Red Grape Pomace over Endothelial Colony-Forming Cells

Current trends in supercritical fluid chromatography

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