Physicochemical Properties and Applications of Poly(lactic-co-glycolic acid) for Use in Bone Regeneration

Lanao, Rosa P. Félix; Jonker, Anika M.; Wolke, Joop G.C.; Jansen, John A.; Hest, Jan C. M. van; Leeuwenburgh, Sander C. G.

doi:10.1089/ten.teb.2012.0443

Cited by 169 publications

(108 citation statements)

References 113 publications

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“…Regarding the LA:GA ratio, the most frequently applied type of PLGA is 50:50, which corresponds to 50% of LA and 50% of GA in the copolymer structure. [4] LA:GA ratio is very important to confer to PLGA specific properties, e.g., the melting temperature. In a study conducted by Lan et Figure 1.…”

Section: Physical-chemical Propertiesmentioning

confidence: 99%

“…[3] These approvals, along with its biocompatibility and biodegradability, make PLGA one of the most used synthetic polymers in the biomedical area. [4] www.advancedsciencenews.com www.advhealthmat.de with a molecular weight between 500 and 2000 Da; (2) thermal unzipping depolymerization of the oligo(lactate) in a vacuum environment under 200-300 °C and using metal-based catalysts, and (3) purification of the crude lactide through solventbased recrystallizations. [10,11] Regarding glycolic acid (GA), its arrangement as building blocks originates polyglycolic acid (PGA), which is the simplest linear aliphatic polyester.…”

Section: Introductionmentioning

confidence: 99%

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Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

205

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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Section: Physical-chemical Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

205

133

View full text Add to dashboard Cite

show abstract

“…PLGA is one of the most beneficial synthetic biodegradable polymers used in the biomedical field and has been approved by FDA (US Food and Drugs Administration) and European Medicine Agency) 36 . PLGA has attracted significant interest as a principle material for medical applications because of its biocompatibility and biodegradation rate depending upon the molecular weight of polymer and ratio of its copolymer.…”

Section: Poly Lactic-co-glycolic Acid (Plga)mentioning

confidence: 99%

Untitled

2018

IJPSR

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“…Fabrication of biomimetic tissue scaffolds containing electrically conducting components is essential to exploit the use of electrical stimulation during tissue regeneration [1][2][3][4][5][6][7] . The conducting scaffold should also mimic the mechanical and topological environment of the targeted tissue or organ [8] .…”

Section: Introductionmentioning

confidence: 99%

“…As such, the first step is to employ a polymer which can mimic natural extracellular matrix (ECM) to match the mechanical properties of the surrounding tissue and display biochemical cues that influence cell behavior. The FDA approved poly lactic-co-glycolic acid (PLGA) is well known to be biocompatible through the copolymer composition, it has tunable mechanical properties and the biodegradation rate can be adjusted [3,5,[9][10][11] . Here we introduce electrical conductivity to the PLGA fibers, while maintaining or enhancing other important properties.…”

Section: Introductionmentioning

confidence: 99%

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

Esrafilzadeh

Jalili

Stewart

et al. 2016

Adv Funct Materials

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The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, it is demonstrated that with the aid of rheological insights, optimized formulations of graphene containing spinnable poly(lactic-co-glycolic acid) (PLGA) dopes can be made possible. This helps extend the general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solutionprocessed graphene into the design process and practical fiber architectural engineering. The as-produced fibers are found to exhibit excellent electrical conductivity and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt%), the conductivity of as-prepared fibers is as high as 150 S m-1 (more than two orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber are enhanced 647-and 59-folds, respectively, through addition of graphene. Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsEsrafilzadeh, D., Jalili, R., Stewart, E. M., Aboutalebi, S. H., Razal, J. M., Moulton, S. The development of electrically conducting fibers based on known cytocompatible materials is of interest to those engaged in tissue regeneration using electrical stimulation. Herein, we demonstrate that with the aid of rheological insights, optimized formulations of graphene 2 containing spinnable Poly Lactic-co-Glycolic Acid (PLGA) dopes can be made possible. This helps us extend our general understanding of the mechanics involved in order to deliberately translate the intrinsic superior electrical and mechanical properties of solution-processed graphene into the design process and practical fiber architectural engineering. The asproduced fibers were found to exhibit excellent electrical conductivity, and electrochemical performance, good mechanical properties, and cellular affinity. At the highest loading of graphene (24.3 wt. %), the conductivity of as-prepared fibers was as high as 150 S m −1 (more than 2 orders of magnitude higher than the highest conductivity achieved for any type of nanocarbon-PLGA composite fibers) reported previously. Moreover, the Young's modulus and tensile strength of the base fiber were enhanced 647-and 59-folds, respectively, through addition of graphene.

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Physicochemical Properties and Applications of Poly(lactic-co-glycolic acid) for Use in Bone Regeneration

Cited by 169 publications

References 113 publications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Untitled

High‐Performance Multifunctional Graphene‐PLGA Fibers: Toward Biomimetic and Conducting 3D Scaffolds

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