2009
DOI: 10.1007/s12272-009-1713-0
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Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate

Abstract: This study was undertaken to evaluate the physicochemical properties and skin permeation of liposome formulations containing clindamycin phosphate (CP), especially when charge was imparted to the liposome. Five different liposome formulations were prepared using Phospholipon 85G (PL) and cholesterol (CH) by conventional lipid film hydration technique. Molar ratio of CH to PL was varied in the range of 0.16-1.0. Charged liposomes were prepared in the same way with addition of 1,2-dioleoyl-3-trimethylammonium-pr… Show more

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Cited by 41 publications
(15 citation statements)
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“…This observation is in agreement with recent studies of liposomes. There, it was shown that cationic liposomes penetrate the skin more efficiently than anionic ones . The enhanced skin permeation of cationic liposomes was attributed to the “Donnan exclusion effect” and is related to the more efficient interaction of cationic particles with the negatively charged skin cells.…”
Section: Resultsmentioning
confidence: 99%
“…This observation is in agreement with recent studies of liposomes. There, it was shown that cationic liposomes penetrate the skin more efficiently than anionic ones . The enhanced skin permeation of cationic liposomes was attributed to the “Donnan exclusion effect” and is related to the more efficient interaction of cationic particles with the negatively charged skin cells.…”
Section: Resultsmentioning
confidence: 99%
“…The positive charge of liposomes is helpful for binding in an ion-exchange manner with the negatively charged skin cells and hair follicles (Jung et al 2006). Shanmugam et al (2009) showed that the steady state flux of drug through the skin is higher for cationic liposomes, followed by anionic and neutral liposomes. The enhanced skin permeation of cationic liposomes is attributed to the permeation selectivity of skin, which is known as ‘Donnan exclusion effect’ (Shanmugam et al 2009).…”
Section: Nanoparticles As Efficient Carriers For Cutaneous Drug Deliverymentioning
confidence: 99%
“…Shanmugam et al (2009) showed that the steady state flux of drug through the skin is higher for cationic liposomes, followed by anionic and neutral liposomes. The enhanced skin permeation of cationic liposomes is attributed to the permeation selectivity of skin, which is known as ‘Donnan exclusion effect’ (Shanmugam et al 2009). Human skin SC is made up of lipids such as ceramides, cholesterol, free fatty acids and cholesteryl sulfate.…”
Section: Nanoparticles As Efficient Carriers For Cutaneous Drug Deliverymentioning
confidence: 99%
“…Since skin layers are known to be negatively charged [44], positively charged vesicles have been shown to improve penetration and retention in the skin [4547]. It is therefore theorized that NVs as well as DNVs having a positive surface charge may fare better in terms of penetration into and retention in the skin as compared to similar neutral or negatively charged NVs [48, 49].…”
Section: Resultsmentioning
confidence: 99%