Physicochemical Characterization and Rheological Behavior Evaluation of the Liquid Crystalline Mesophases Developed with Different Silicones

Prestes, Paula Souza; Chorilli, Marlus; Chiavacci, Leila Aparecida; Scarpa, Maria Virgínia; Leonardi, Gislaine Ricci

doi:10.1080/01932690903123841

Cited by 22 publications

(14 citation statements)

References 13 publications

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“…One of the advantages of LCs is that they can be stored for long periods because they are thermodynamically stable. 180 Polarized light microscopy is one of the characterization techniques that is used for the preliminary identification of mesophase LCs. 181 In this analysis, a sample undergoes the incidence of polarized light, which is enough to deflect light and is called anisotropic (it can be mesophase lamellar or hexagonal).…”

Section: Liquid Crystalsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Calixto¹,

Fonseca-Santos²,

Chorilli³

et al. 2014

IJN

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146

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Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.

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Section: Liquid Crystalsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Calixto¹,

Fonseca-Santos²,

Chorilli³

et al. 2014

IJN

Self Cite

146

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“…Liquid crystalline systems (LCS) are mesomorphic phases of matter in an intermediate state in the thermal transformation from a solid to a liquid. LCS have the characteristic properties of solids and liquids: they have the structural order, rigidity, and defined links as in solids, and they also have the mobility, fluidity, and disordered regions as in liquids (Chorilli et al, 2011;Prestes et al, 2009;Mezzenga, 2012). MEs are defined as dispersion made of water, oil, and surfactants that is an isotropic and thermodynamically stable system with dispersed in globular or interconnected size diameter varying approximately from 1 to 100 nm, usually 10 to 50 nm (Slomkowski et al, 2011;McClements, 2012).…”

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confidence: 99%

Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion

Fonseca-Santos

Funagoshi

Oliveira

et al. 2017

Braz. J. Pharm. Sci.

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This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders. Keywords:Liquid crystals/evaluation/physical-chemical stability. Microemulsions/evaluation. Surfactant-based system. Organic cocoa extract. Skin bioadhesion. INTRODUCTIONSkin is routinely exposed to stressful environmental factors such as pollutants and UV radiation. These factors produce a large number of aggressive oxidants that damage all of the biological skin cell membranes (Silva et al., 2010;Binic et al., 2013;Datta et al., 2011;Dupont, Gomez, Bilodeau, 2013). Accordingly, the use of skin care products and cosmetics has been utilized to mitigate the cutaneous photoaging process (Visscher, Pan, Kitzmiller, 2013) and these products are commonly composed of plant extracts (Binic et al., 2013).A great number of plants and plant extracts are studied for their antioxidative action arising from their phenolic substructures. Phenolic compounds are composed of an aromatic ring that is linked to a hydroxyl group, which donates electrons and hydrogen atoms. As a result, these compounds are exceptional antioxidants (Silva et al., 2010;Binic et al., 2013;Reuter, Merfort, Schempp, 2010).Cocoa, the dried and fermented seeds derived from Theobroma cacao, has been consumed since 1100 B.C. by ancient civilizations such as the Mayans and Aztecs (Hurst et al., 2002). Cocoa contains high amounts of the flavonoids (−)-epicatechin (EC) and (+)-catechin, and procyanidins B2 and B1. Additionally, other polyphenols such as quercetin, isoquercitrin (quercetin 3-O-glucoside), quercetin 3-O-arabinose, hyperoside (quercetin 3-O-galactoside), naringenin, luteolin, and apigenin have also been found in cocoa in minor quantities (Sánchez-Rabaneda et al., 2003). While the natural amount B. Fonseca-Santos, E. E. Funagoshi, J. R. S. Olivei...

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“…They are thermodynamically stable and can be classified as either thermotropic or lyotropic systems. Thermotropics are formed by arrangement of individual molecules (pure substances) and lyotropics, by micelles (surfactants mixed with a solvent, usually water) (Aouada et al, 2006;Chorilli et al, 2009;Prestes et al, 2010;Chorilli et al, 2011;Calixto et al, 2014;Oyafuso et al, 2015). It is well known that surfactants tend to spontaneously self-associate and can form highly ordered aggregates, such as lamellar, hexagonal, and cubic liquid crystalline phases, at higher concentrations (Fraser et al, 2009;Calixto et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…These studies help to guide the development of appropriate formulation and packaging materials and provide support for improved formulations. Furthermore, these studies can estimate the shelf life of a product, assist in monitoring the organoleptic, physicochemical, and microbiological stabilities, and provide information about the reliability and safety of products (Prestes et al, 2010;ANVISA, 2004).…”

Section: Introductionmentioning

confidence: 99%

Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

Bernegossi

Barbosa

Rustice

et al. 2016

Braz. J. Pharm. Sci.

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Liquid crystal systems (LCSs) have interesting cosmetic applications because of their ability to increase the therapeutic efficiency and solubility of active ingredients. The aim of the present research was to develop green tea glycolic extract-loaded LCSs, to characterize and to perform microbiological control. The ternary phase diagram was constructed using polysorbate 20, silicone glycol copolymer (SGC) , and distilled water with 1.5% glycolic green tea extract. The systems were characterized by polarized light microscopy. Formulations selected were characterized as transparent viscous systems and transparent liquid system indicated mesophases lamellar structure. The results of the microbiological analysis of mesophilic aerobic microorganisms (bacteria and fungi) revealed that the above formulation showed a biologic load <10 CFU/mL in all samples. In conclusion, liquid crystalline systems that have presented formation of a lamellar mesophases were developed. Furthermore, the formulation and products tested presented the adequate microbiological quality in accordance with official recommendations. Uniterms:Camellia sinensis/glycolic extract. Liquid crystal systems/cosmetic applications. Liquid crystal systems/characterization. Liquid crystal systems/microbiological control. INTRODUCTIONTechnological developments in the cosmetics industry and improved understanding of skin physiology have led to the incorporation of several active substances that are now commonly used in cosmetic formulations. Plant extracts, especially green tea glycolic extract, have been recently proposed for different purposes (Gianeti et al, 2013).Green tea, obtained from the plant Camellia sinensis, is rich in polyphenols, such as catechins. The most active catechin seems to be 3-gallate (-) epigallocatechin. Clinical studies show that green tea acts as a chemoprotectant and sunscreen agent with activities such as antioxidant, free radical scavenging, inhibiting the induction, initiation, promotion, and proliferation of carcinogenesis, antiinflammatory, antiangiogenic, inducer of apoptosis of carcinogen cells, metalloproteinase inhibitor, protector of the conversion of benign cells into malignant, and inhibitor of DNA damage (Pereira et al., 2009;Yun, Yang, 2015;Rodrigues et al., 2016).Studies performed by our research group compared pomegranate and green tea glycolic extracts (GTGE) in formulations and concluded that GTGE possessed greater bacterial growth inhibition measured as zone of inhibition than the other extracts, suggesting that GTGE has high antibacterial activity (Calixto et al., 2012).With the aim of obtaining final products with real benefits that can be perceived by consumers and to optimize the sensory attributes of these formulations, researchers have resorted to theories and scientific experimentations that were unique to the development of pharmaceutical preparations. Active substance delivery systems that were previously developed for pharmaceutical products (e.g., micro-and nanoemulsions and liquid-crystalline system...

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Physicochemical Characterization and Rheological Behavior Evaluation of the Liquid Crystalline Mesophases Developed with Different Silicones

Cited by 22 publications

References 13 publications

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion

Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

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