Physicochemical characterization and pharmacological evaluation of marine polyphenols from the brown algae Padina pavonica

Abstract

Background and Aim: Natural products continue to be a primary resource in biomedicine and biotechnology. The marine environment is highly reserve for novel pharmaceutical and medical compounds. The aim of this work was to identify bioactive components from the brown seaweed Padina pavonica with specific pharmacological potential. Methods: In the present study, we investigated the efficacy of polyphenol fraction from Padina pavonica for in vivo anti-inflammatory activity using the carrageen an-induced paw edema model in rats and there in vitro antioxidant activity using two methods: DPPH radical scavenging assay and ferric reducing antioxidant power (FRAP) [8]. Results: The polyphenol-rich fraction from the brown seaweed Padina pavonica exhibits a significant anti-inflammatory activity at the dose of 100 and 200 mg/kg and the maximum reduction of the edema was observed at the third hour with 53.49% and 58.6% of inhibition, respectively. Along with, we were interested in the investigation of the antioxidant activity. The DPPH radical-scavenging assay shows that the polyphenol fractions have an interesting cavenging activity at a low concentration (0.25 mg/mL). In addition, the Ferric reducing antioxidant power (FRAP) method reveals an antioxidant activity with IC50 = 0.4 mg/mL. Conclusions: These findings indicate that the polyphenol fraction of Padina pavonica is a promising bio source of compounds with anti-inflammatory and antioxidant potential; this may be useful as a candidate for the developing of potential therapeutic products. Keywords: Brown Seaweeds; Padina pavonica; Anti-Inflammatory Activity; Antioxidant Activity

Bioactivity and metabolomics fingerprinting characterization of different organic solvents extracts of Padina pavonica collected from Abu Qir Bay, Egypt

“…These antioxidant molecules are created in their body tissues in response to the harsh environment in which they inhabit [60]. Alshaikheid et al [20] investigated the efficiency or efficacy of the polyphenol fraction of P. pavonica for in vitro antioxidant activity using DPPH radical scavenging assay method. These findings indicated that the polyphenol fraction of P. pavonica is a promising bio source of compounds with antioxidant potential [12].…”

“…It is a source of bioactive metabolites that are not found in other species and is used in the pharmaceutical industry. These antioxidant molecules are created in the body's tissues in response to the harsh environment in which they live [20]. Antibacterial chemicals produced by macro algae of Egyptian Journal of Chemistry http://ejchem.journals.ekb.eg/ 2025 the P. Pavonica are useful in inhibiting the growth of many infections in humans and other animals [21].…”