We report an organophotocatalytic, N-CH3-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new catalyst (DCAS) was designed with solubilizing groups for flow processing. This...
A photocatalyst-free
and mild visible light photochemical procedure
for C(sp3)–H arylation of amides is described. The
reaction proceeds via an electron donor–acceptor (EDA) complex
between an electron-rich arene substrate and electron-poor persulfate
oxidant. C(sp3)–H arylation of the amide occurs
selectively with the most electron-rich arene of the substrate. Mechanistic
studies corroborate the reaction taking place in a solvent cage holding
components in a close proximity.
Benzoates serve as catalysts or auxiliaries for photochemical EnT radical C(sp3)–H fluorinations. The auxiliary markedly increases scope and efficiency, enabling reactions of free alcohols, amines, and allowing rapid gram-scale fluorinations in air.
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