Physicochemical Characterization and Analgesic Effect of Inclusion Complexes of Essential Oil from Hyptis pectinata L. Poit Leaves with &amp;#946;-Cyclodextrin

Menezes, Paula dos Passos; Araújo, Adriano Antunes de Souza; Dória, Grace Anne Azevedo; Quintans‐Júnior, Lucindo José; Oliveira, Makson Gleydson Brito de; Santos, Márcio Roberto Viana dos; Oliveira, Juliana Ferreira de; Matos, Jivaldo do Rosário; Carvalho, Flávio; Alves, Péricles Barreto; Matos, Iara Lisboa de; Santos, Darlisson A; Marreto, Ricardo Neves; Silva, Gabriel Francisco da; Serafini, Mairim Russo

doi:10.2174/1389201015666141202101909

Cited by 40 publications

(23 citation statements)

References 23 publications

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“…The major compounds reported in this study corroborate other works involving the essential oil of H. pectinata, in which the main chemical compounds commonly detected were: pcymene (33.7%), β-pinene (6.95%), β-caryophyllene (7.00-54.07%), caryophyllene oxide (1.98-38.05%), calamusenone (1.85-48.00%), , 2008, ARRIGONI-BLANK et al, 2010, RAYMUNDO et al, 2011, MENEZES et al, 2015.…”

Section: Resultssupporting

confidence: 90%

Chemical diversity of essential oils from Hyptis pectinata (L.) Poit

Feitosa-Alcantara¹,

Arrigoni-Blank²,

Blank³

et al. 2018

Biosci. J.

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Section: Resultssupporting

confidence: 90%

Chemical diversity of essential oils from Hyptis pectinata (L.) Poit

Feitosa-Alcantara¹,

Arrigoni-Blank²,

Blank³

et al. 2018

Biosci. J.

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“…The poor bioavailability of hydrophobic drugs demands the use of high doses to overcome subtherapeutic levels in plasma. 7 To solve this limitation, a large number of studies have been published describing new delivery systems such as inclusion complexes with cyclodextrins [8][9][10][11] and nanoparticles. 7,[12][13][14][15] Nanoparticle systems have been considered promising carriers of therapeutic drugs, and the application of these particles as carriers of natural compounds has been extensively studied over the past few years.…”

mentioning

confidence: 99%

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Menezes

Frank

Lima

et al. 2017

IJN

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Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials.

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“…For instance, the complexation of Hyptis pectinata L. EO with β-CD improved its analgesic effect in a mice model [34]. Also Bomfim et al observed that β-CD complexation increased in vivo tumor growth inhibition capacity of Annona vepretorum EO [32].…”

Section: Interaction Between Phytochemicals and Cyclodextrinsmentioning

confidence: 99%

Interactions between Bio-Based Compounds and Cyclodextrins

Medronho¹,

Gonçalves²,

RaquelRodríguez-Solana³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Bio-based compounds, such as "green" surfactants and phytochemicals, are regarded as future sustainable resources for a vast range of applications in a modern society increasingly demanding economical, social, and environmental awareness. Natural compounds from plants (phytochemicals) are very sought by the pharmaceutical, cosmetic, and food industries. On the other hand, the growing interest in "green" surfactants (e.g., carbohydrate-based) is due to, inter alia, their preparation from renewable raw materials, ready biodegradability, and biocompatibility, among other reasons of fundamental, practical, economical, and environmental orders. Despite the wide range of potential applications of these bio-based compounds, their practical use is still limited due to many reasons such as poor aqueous solubility, volatility, reactivity, etc. Generally, when complexed with cyclodextrins, these biobased compounds enhance considerably their performance and potential applications. Thus, this chapter aims at recalling some general fundamental aspects of phytochemicals and "green" surfactants, such as structure, function, and applications. In addition, their interactions with cyclodextrins are discussed from a physicochemical point of view with special focus on the techniques, mathematic modeling, and thermodynamic parameters (e.g., interactions, stoichiometries, association constants, etc.).

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Physicochemical Characterization and Analgesic Effect of Inclusion Complexes of Essential Oil from Hyptis pectinata L. Poit Leaves with β-Cyclodextrin

Cited by 40 publications

References 23 publications

Chemical diversity of essential oils from Hyptis pectinata (L.) Poit

Chemical diversity of essential oils from Hyptis pectinata (L.) Poit

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Interactions between Bio-Based Compounds and Cyclodextrins

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