Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Abstract

Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials.

Research progress on the mechanism of action of hesperetin in cerebral ischemia: a narrative review

“…At present, hesperetin is used clinically as an auxiliary drug for the treatment of cardiovascular diseases and diabetes. In addition, since hesperetin has a selective inhibitory effect on cancer cells and has no effect on normal human cells, it can be used as an auxiliary drug for the treatment of cancer patients who are resistant to chemotherapy and radiotherapy (41,42).…”

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

“…To increase the drug delivery potential for topical applications, Menezes et al. 110 reported to fabricate textile-based Hesp-loaded nanocapsules. These fabric-based nanocapsules were found to be suitable for sustained release of drug.…”

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

“…This study showed the significantly higher extraction of drugs through LNCs as compared to the conventional one. Further, LNCs showed increased retention in the stratum corneum and thus provided controlled drug release [79]. Polyamides are also explored for sutures in cutaneous surgery and clinical treatments of wounds by Sun et al [80].…”