Physicochemical, Biochemical, Pharmacological Properties of Magnesium

Abstract

Connection of the publication with planned research works.The article is presented as part of the planned research work of the Department of Pharmacology on "Experimental Substantiation of Combined Use of Cardiotropic Drugs" (Registration No. 0111U009417). Introduction.In addition to vitamins and hormones, micro -and macroelements are necessary for the functioning of the body and normal functioning of organs and systems. In previous publications, the pharmacological properties of zinc, iron, selenium, amino acids were revealed, and their role in the functioning of the body and the development of new drugs was determined.At the same time, significant attention is currently focused on the role of magnesium, which is a key microelement in the body and is second only to potassium in terms of content. Magnesium, the twelfth element of the The article discusses the role of magnesium in the body, which is one of the main intracellular elements that plays a leading role in the activity of vital organs, participates in many cellular functions including signal transmission, energy production, protein metabolism, and acts as a molecular stabilizer for RNA and DNA ribosomes. Hypomagnesemia leads to disturbances in the cardiovascular, nervous, immune, and digestive systems. Based on magnesium, mono (magnesium sulfate, magnesium citrate, etc.) and complex preparations (MagneВ6, Maalox, ATP forte, etc.) have been created and are being created. Imbalances in magnesium content are associated with the development of cardiovascular diseases such as arterial hypertension, arrhythmias, heart failure, as well as the occurrence of neurodegenerative diseases of the CNS (parkinsonism, Alzheimer's disease, dementia), as magnesium is involved not only in nucleic acid metabolism but also in signal transmission in the CNS. Therefore, monitoring magnesium levels in the cardiovascular, nervous, and other systems may be a target for the influence of magnesium preparations. In individuals with digestive tract diseases, changes in magnesium content have also been identified in the cardiovascular system and CNS. Changes in magnesium content are associated with the occurrence of cardiovascular and digestive tract diseases in children, as well as the course of pregnancy in women. This indicates the need for further research into the properties of this trace element in normal and pathological conditions, as well as the search for new methodological approaches to determining its functional impact on the human body.

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“…Potassium and magnesium taurate are frequently taken as supplements to help control hypertension. Combining magnesium and taurine can result in magnesium taurate, which has the potential to relax blood vessels and enhance blood flow (20). On the other side, potassium balances the body's salt levels, which helps control blood pressure (21).…”