Physicochemical aspects of drug release. IV. The effect of carrier particle properties on the dissolution rate from ordered mixtures

A Novel Tablet-Based13C Urea Breath Test for Helicobacter pylori with Enhanced Performance during Acid Suppression Therapy

“…One major advance of the present formulation is thus that we have created a solid dosage form of 13 C urea (ready-to-use tablet), characterized by an almost instantaneous disintegration and dissolution of the 13 C urea tablet after entering the stomach (20)(21)(22)(23). When testing this new tablet, we found that in comparison with a conventional urea drink UBT performed with a test meal, the tablet-based UBT performed while fasting gave greater separation between positive and negative results at early time points ( 20 min).…”

“…The urea was milled to obtain a fine particulate quality with high surface area. Further, the concept of ordered mixing (20) was applied to counteract agglomeration of the fine urea quality (21) and thus optimize both drug dissolution (22) and mixture quality (23). To obtain both a deagglomeration of the fine particulate quality of urea and also an adhesion of primary urea particles to the coarser citric acid particles, both components were admixed for 2 h. To enhance adequate compactability and disintegration, two cellulose-based excipients, Avicel Ph 101 (60 mg/tablet) and Ac-Di-Sol (24 mg/ tablet) were admixed in the ordered mixture of urea.…”

In vitro/in vivo Correlation of Fast Release Mephenamic Acid Microspheres in Humans

“…The pharmacokinetics of MFA after oral administration have been investigated previously by some authors [3,5,15]. The reported peak plasma level after a 1-gram oral dose was found to be 10 µg/ml [16].…”

“…MFA is characterized by low aqueous solubility (41 µg/ml), therefore the dissolution rate is expected to be limited and the in vivo absorption might be erratic [3]. Many attempts have been made to improve the dissolution rate of poorly water-soluble drugs by dispersion of the drugs in water-soluble carriers [4,5,6]. Moreover, the bioavailability of MFA has been studied by many investigators [7,8,9].…”

Functionalised particles using dry powder coating in pharmaceutical drug delivery: promises and challenges

“…Allahham and co-worker [84] modelled the dissolution data using a bi-exponential equation (one related to dissolution from aggregated particles and the second is from dispersed particles). Dispersion of guest particle onto the surface of the host increases the dissolution of sparingly soluble drugs by mixing them with a water-soluble host where the dissolution rate increase is due to the increase in surface area and enhancement of the wettability [79,[85][86][87][88].…”