A Novel Tablet-Based<sup>13</sup>C Urea Breath Test for Helicobacter pylori with Enhanced Performance during Acid Suppression Therapy

Hamlet, A.; Stage, Lars; Lönroth, Hans; Cahlin, Christian; Nyström, Christer; Pettersson, A.

doi:10.1080/003655299750026371

Cited by 43 publications

(2 citation statements)

References 21 publications

(35 reference statements)

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“…Hamlet et al more than a decade ago, examined the efficacy and duration of 14 C-UBT using similar methods [18,19]. They reported that by supplying 14 C-urea as a rapid -release tablet along with citric acid, it is possible to shorten the duration of the UBT to 10 minutes with excellent accuracy, even during acid suppression therapy.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that by supplying 14 C-urea as a rapid -release tablet along with citric acid, it is possible to shorten the duration of the UBT to 10 minutes with excellent accuracy, even during acid suppression therapy. The tablet-based UBT proved to be accurate during omeprazole treatment, correctly identifying all of the 10 H. pylori -infected patients [19]. …”

Section: Discussionmentioning

confidence: 99%

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Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

et al. 2012

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BackgroundCarbon labeled urea breath tests usually entail a two point sampling with a 20 to 30-minute gap. Our aim was to evaluate the duration of time needed for diagnosing Helicobacter pylori by the BreathID® System.MethodsThis is a retrospective multicenter chart review study. Test location, date, delta over baseline, and duration of the entire test were recorded. Consecutively 13C urea breath tests results were extracted from the files over a nine year period.ResultsOf the 12,791 tests results, 35.1% were positively diagnosed and only 0.1% were inconclusive. A statistically significant difference in prevalence among the countries was found: Germany showing the lowest, 13.3%, and Israel the highest, 44.1%. Significant differences were found in time to diagnosis: a positive diagnosis had the shortest and an inconclusive result had the longest. Overall test duration averaged 15.1 minutes in Germany versus approximately 13 minutes in other countries. Diagnosis was achieved after approximately 9 minutes in Israel, Italy and Switzerland, but after 10 on average in the others. The mean delta over baseline value for a negative diagnosis was 1.03 ± 0.86, (range, 0.9 - 5), versus 20.2 ± 18.9, (range, 5.1 - 159.4) for a positive one.ConclusionsThe BreathID® System used in diagnosing Helicobacter pylori can safely shorten test duration on average of 10-13 minutes without any loss of sensitivity or specificity and with no test lasting more than 21 minutes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

et al. 2012

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Non-invasive diagnostic tests for Helicobacter pylori infection

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Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

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124

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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Urea Breath Tests for Detection of Helicobacter pylori

Wang¹,

Zheng²

Advanced Techniques in Diagnostic Microbiology

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A Novel Tablet-Based¹³C Urea Breath Test for Helicobacter pylori with Enhanced Performance during Acid Suppression Therapy

Abstract: By supplying 13C urea and citric acid as a rapid-release tablet, it is possible to shorten the duration of the 13C UBT to 10 min, omit the test meal, and still maintain excellent accuracy, even during acid suppression therapy.

Cited by 43 publications

References 21 publications

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

Non-invasive diagnostic tests for Helicobacter pylori infection

Urea Breath Tests for Detection of Helicobacter pylori

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A Novel Tablet-Based13C Urea Breath Test for Helicobacter pylori with Enhanced Performance during Acid Suppression Therapy

Abstract: By supplying 13C urea and citric acid as a rapid-release tablet, it is possible to shorten the duration of the 13C UBT to 10 min, omit the test meal, and still maintain excellent accuracy, even during acid suppression therapy.

Cited by 43 publications

References 21 publications

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

Applicability of a short/rapid 13C-urea breath test for Helicobacter pylori: retrospective multicenter chart review study

Non-invasive diagnostic tests for Helicobacter pylori infection

Urea Breath Tests for Detection of Helicobacter pylori

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Product

Resources

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A Novel Tablet-Based¹³C Urea Breath Test for Helicobacter pylori with Enhanced Performance during Acid Suppression Therapy