Physicochemical and Biological Evaluation of Endodontic Filling Materials for Primary Teeth

Pilownic, Katerine Jahnecke; Gomes, Ana Paula Neutzling; Wang, Zhe Jun; Almeida, Leandro Pelegrini de; Romano, Ana Regina; Shen, Ya; Felix, Anelize de Oliveira Campello; Haapasalo, Markus; Pappen, Fernanda Geraldo

doi:10.1590/0103-6440201701573

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…The BS values obtained for the zinc oxide-based sealer (Endofill) and the mineral aggregate-based sealer (MTA Fillapex) in the present study were similar, as reported by other study (4). Despite of its low adhesion to dentin, zinc oxide-based sealers are widely used in several clinical procedures (15). This type of sealer has low resistance to compression, and low cohesion of its molecules, which can explain the low BS to dentin, and the highest number of adhesive failures verified after the push-out test (4).…”

Section: Discussionsupporting

confidence: 90%

Correlation between Bond Strength to Dentin and Sealers Penetration by Push-Out Test and CLSM Analysis

et al. 2019

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This study correlated the bond strength (BS) and dentin penetration of different sealers by push-out test and Confocal Laser Scanning Microscopy (CLSM) analysis. Forty-five root canals were prepared according to the crown-down technique and filled with gutta-percha associated to the following sealers (n=15): Endofill, AH Plus and MTA Fillapex. Five canals of each group were filled with the sealers added with 0.1% Rhodamine B dye. Next, the specimens were transversely sectioned and submitted to the push-out test (n=10) and CLSM analysis (n=5). The BS data showed the following means (MPa) and standard deviation: AH Plus (4.17±1.86); MTA Fillapex (3.13±1.96) and Endofill (2.10±1.03). Statistical analysis (two-way ANOVA, α=0.05) showed significant difference among sealers (p<0.001) and root canal thirds (p<0.001). The BS results of Endofill and MTA Fillapex were statistically similar (p>0.05), however, they were statistically different from AH Plus (p<0.001). The regional analysis of BS showed similarity between middle and apical thirds (p>0.05), and both were different from coronal portion (p<0.001). CLSM analysis verified tags formation in all groups and higher penetration of the specimens filled with AH Plus (p<0.05). The Kendall test (correlation between BS to dentin and sealer penetration into dentinal tubules) and the Pearson test (between failures pattern and sealer penetration into dentinal tubules) did not show correlation between the variables evaluated for all the tested sealers (p>0.05). AH Plus group had higher BS to dentin, and deeper tags formation than the other sealers. There was no significant correlation between BS and intratubular penetration of the tested sealers.

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Section: Discussionsupporting

confidence: 90%

Correlation between Bond Strength to Dentin and Sealers Penetration by Push-Out Test and CLSM Analysis

et al. 2019

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“…5 Calen thickened with zinc oxide (Calen-ZO) has been used as a root canal filling material in the primary dentition. [6][7][8] The addition of zinc oxide (ZO) reduces the phagocytosis of Calen, thus allowing Calen to accompany the physiological resorption of primary tooth roots, and improve its physicochemical properties. 7,9 Calen-ZO induces good tissue response, 7,10 has antimicrobial activity 6 , and is more biocompatible than ZOE.…”

Section: Introductionmentioning

confidence: 99%

“…7,9 Calen-ZO induces good tissue response, 7,10 has antimicrobial activity 6 , and is more biocompatible than ZOE. 7,8 New endodontic cements have been developed, especially highlighting the advance in improved bioceramics. The main characteristics of bioceramic materials for endodontic use are their alkaline pH, shrink-free property, chemical stability within the biological environment, 11,12 biocompatibility and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

“…16 In addition, a root filling material for primary teeth developed by Angelus, with similar composition of Bio-CP, but with the name not informed, showed good biocompatibility in the subcutaneous tissue of rats, low cytotoxicity in human gingival fibroblast, and satisfactory behaviour regarding the physicochemical properties studied. 8 However, the scientific literature about Bio-CP is still scarce.…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology

et al. 2021

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Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology Bio-C Pulpecto (Bio-CP) was recently developed as the first bioceramic root filling material for primary teeth. Objective: To evaluate the physicochemical properties of radiopacity, setting time, pH, cytocompatibility and potential of Bio-CP to induce mineralisation, compared with (1) Calen thickened with zinc oxide (Calen-ZO), and (2) zinc oxide and eugenol (ZOE). Methodology: Physicochemical properties were evaluated according to ISO 6876. Saos-2 (human osteoblast-like cell line) exposed to extracts of the materials were subjected to assays of methyl thiazolyl tetrazolium, neutral red, alkaline phosphatase (ALP) activity and mineralised nodule production. The results were analysed using one-way or two-way ANOVA and Tukey's or Bonferroni's post-tests (α=0.05). Results: All the materials showed radiopacity higher than 3 mm Al. Bio-CP had lower pH than Calen-ZO, but higher pH than ZOE. Calen-ZO and Bio-CP did not set. The setting time for ZOE was 110 min. The cytocompatibility order was Calen-ZO > Bio-CP > ZOE (1:2, 1:4 dilutions) and Calen-ZO > Bio-CP = ZOE (1:12, 1:24 dilutions) and Calen-ZO = Bio-CP > ZOE (1:32 dilution). Bio-CP induced greater ALP activity at 7 days, and greater mineralised nodule production, compared to Calen-ZO (p<0.05). Conclusions Bio-CP showed adequate physicochemical properties, cytocompatibility and potential to induce mineralisation.

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“…Due to the small antibacterial effects of zinc oxide eugenol and its slower adsorption rate in comparison to the roots of primary teeth, remnants exited between the root zone and apex of the tooth after exfoliation of primary teeth, causes the deformation of the underlying permanent tooth (7). Moreover, foreign body reactions and cytotoxic effects have also been reported with this type of filler (8).…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial effects of zinc oxide-calcium hydroxide mixture fillers: determining the ideal mixture ratio

Nozari¹,

Karimkhani²,

Motamedifar³

et al. 2019

IJM

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Background and Objectives: Although zinc oxide (ZO)-calcium hydroxide (CaOH) mixtures have been successful regard- ing their absorption rate compatibility with dissolving primary teeth, no study has been conducted on the appropriate mixture ratio to obtain effective antibacterial properties. In this study, we compared antibacterial activity of CaOH-ZO pastes using different mixture ratios sagainst Enterococcus faecalis as an important bacterium in root canal treatment failure. Materials and Methods: Seven types of pastes were prepared in our laboratory. The first group included one gram of ZO+eu- genol, second group included one gram of CaOH+distilled water, third group included 0.5gram ZO+0.5gram CaOH+distilled water (1:1), forth group included 0.75gramCaOH+0.25gramZO+distilled water (3:1), the fifth group included 0.33gram of CaOH+0.66gram of ZO+distilled water (1:2), the sixth group included 0.75gram of ZO+0.25 CaOH+distilled water (3:1), the seventh group included 0.66 gram CaOH+0.33 gram ZO+distilled water (2:1), and the final group included one gram of gelatin+distilled water (as the control group). These pastes were compared regarding their antibacterial effects against Enterococcus faecalis using agar diffusion and microdilution methods. Results: Except for the control group, all prepared pastes showed antibacterial properties. Order of minimum inhibitory concentration for pastes were as followed: CaOH-ZO (1:3)=CaOH-ZO (1:2)>CaOH-ZO (1:1)>CaOH-ZO (3:1)=CaOH-ZO (2:1)>CaOH=ZO-eugenol. Order of minimum bactericidal concentration, which shows a weaker bactericidal effect, accord- ing to type of paste, were as followed: CaOH-ZO (1:3)>CaOH-ZO mixture (1:2)>CaOH-ZO mixture (1:1)>CaOH-ZO mix- ture (3:1)=CaOH-ZO (2:1)>CaOH=ZO-eugenol. Only CaOH-ZO (1:3) and CaOH-ZO (1:2), showed significantly weaker MICs and MBCs (p < 0.001). Conclusion: Considering the limitations of an in-vitro study, in terms of anti-bacterial effects against Enterococcus faecalis, CaOH-ZO mixture (2:1) is equivalent to ZO-eugenol as the most commonly used material in polypectomy of primary teeth.

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Physicochemical and Biological Evaluation of Endodontic Filling Materials for Primary Teeth

Cited by 16 publications

References 21 publications

Correlation between Bond Strength to Dentin and Sealers Penetration by Push-Out Test and CLSM Analysis

Correlation between Bond Strength to Dentin and Sealers Penetration by Push-Out Test and CLSM Analysis

Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology

The antimicrobial effects of zinc oxide-calcium hydroxide mixture fillers: determining the ideal mixture ratio

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