Physicochemical and antimicrobial properties of <i>in situ</i> crosslinked alginate/hydroxypropyl methylcellulose/ε‐polylysine films

Blachechen, Tatiana Schafranski; Petri, Denise Freitas Siqueira

doi:10.1002/app.48832

Cited by 13 publications

(5 citation statements)

References 44 publications

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“…Moreover, improved physicochemical and mechanical properties of edible films by incorporating both CMC and HPMC have been reported in various studies. [26][27][28][29] Therefore, the present study was designed to investigate the role of CMC and HPMC on the physiochemical properties of the alginate/aloe vera composite films particularly as reinforcing materials for improving the mechanical properties of these films.…”

Section: Introductionmentioning

confidence: 99%

Sustainable alginate/aloe vera composite biodegradable films reinforced with carboxymethyl cellulose and hydroxypropyl methylcellulose

et al. 2022

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Biopolymers like polysaccharides are being used to develop biodegradable and edible food packaging films. These films are environment friendly but have inferior mechanical strength as compared to conventional plastics. This study seeks to enhance the mechanical properties of alginate aloe vera composite films by the fusion of organic fibers like carboxymethyl cellulose (CMC) and hydroxypropyl methylcellulose (HPMC). CMC and HPMC were added at varying concentrations (2%–14%).Addition of both these cellulose derivatives had a positive effect on the tensile strength and elongation at break of the composite films. The tensile strength increased to a maximum value of 35.08 and 51.96 N/mm2 in CMC and HPMC films, respectively at 4% concentration of both. Increasing the fiber concentration further resulted in a decrease of tensile strength. Similar trend was observed in the flexibility of the films as the elongation at break value was maximum 5.57% and 3.21%, respectively at 4% concentration. The addition of CMC reduced the water solubility of the film. The solubility decreased to 19% at the maximum concentration of CMC. The effect of HPMC on water solubility was opposite to that of CMC. The solubility of the film increased to 86.42% at highest concentration of HPMC. CMC slowed down the biodegradation rate of the films whereas HPMC increased it.

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Section: Introductionmentioning

confidence: 99%

Sustainable alginate/aloe vera composite biodegradable films reinforced with carboxymethyl cellulose and hydroxypropyl methylcellulose

et al. 2022

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“…Hydroxypropyl methylcellulose (HPMC) has low‐cost, film‐forming properties and mechanical properties, which is widely used in the food and pharmaceutical industries (Blachechen & Petri, 2019). HPMC is also odourless, tasteless and non‐toxic and is widely applied in controlled release preparations (Ghorpade et al ., 2016).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and characterisation of grape seed proanthocyanidin extract using sodium alginate and different cellulose derivatives

Sheng

Zhang

Kong

et al. 2021

Int J of Food Sci Tech

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Grape seed proanthocyanidin extract (GSPE) has health benefits. However, these phenolic compounds undergo degradation reactions and have undesirable sensorial characteristics. GSPE was encapsulated using sodium alginate (SA), SA-methyl cellulose (MC) and SA-hydroxypropyl methylcellulose (HPMC) for promoting controlled release, pH stability, temperature and storage period tolerance of GSPE. The microcapsules were characterised using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) analysis. The SA-MC and SA-HPMC microcapsules appeared to have a more compact surface than SA-alone microcapsules. FTIR analysis indicated successful immobilisation of GSPE into the polymeric microcapsules. Moreover, the SA-MC and SA-HPMC microcapsules showed higher thermal stability. The microcapsules showed a relatively higher amount of released GSPE at a pH above six than at a lower pH. The SA-MC and SA-HPMC microcapsules could be used to retain more GSPE content in the gastric phase and to release it in the intestinal phase for possible absorption. Furthermore, after 28 days of storage at 25 °C, the GSPE retention rate of the microcapsules was still higher than 80%. GSPE encapsulated in SA-MC and SA-HPMC microcapsules results in lesser degradation and can be absorbed more effectively. This method has potential for the delivery of colon-specific materials while exhibiting a sustained-release characteristic.

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“…Similarly, crosslinked alginate/hydroxypropyl methylcellulose/ε-polylysine films with low content of plasticizers showed 99.9% bacterial reduction in both E. coli and S. aureus strains. It is noted that ε-PL should be used moderately because it competes for alginate chains, making the films more fragile [ 67 ]. Lastly, a novel antimicrobial nanocomposite was developed based on corona treated polypropylene (CPP), added with alginate and copper oxide nanoparticles; this nanocomposite exhibited excellent antimicrobial activity against E. coli , S. aureus , and Candida albicans [ 68 ].…”

Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections.

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Physicochemical and antimicrobial properties of in situ crosslinked alginate/hydroxypropyl methylcellulose/ε‐polylysine films

Cited by 13 publications

References 44 publications

Sustainable alginate/aloe vera composite biodegradable films reinforced with carboxymethyl cellulose and hydroxypropyl methylcellulose

Sustainable alginate/aloe vera composite biodegradable films reinforced with carboxymethyl cellulose and hydroxypropyl methylcellulose

Encapsulation and characterisation of grape seed proanthocyanidin extract using sodium alginate and different cellulose derivatives

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

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