Physicochemical and antimicrobial properties of sodium alginate/gelatin-based silver nanoformulations

Acharya, Chinmayee; Panda, C. S.; B, Prakash Kumar; Sasmal, Abhisek; Shekhar, Suman; Sen, Asim K.

doi:10.1007/s00289-016-1738-8

Cited by 20 publications

(5 citation statements)

References 56 publications

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“…The antifungal effect of CH are well documented [ 82 ], however, the similar effect of CH and AG coatings on spore germination for the test fungi ( B. cinerea and Penicillium spp.) suggests that AG also exhibits antimicrobial effects, previously observed when tested against Gram negative bacteria [ 83 ].…”

Section: Discussionmentioning

confidence: 78%

A Comparative Study of Antimicrobial and Antioxidant Activities of Plant Essential Oils and Extracts as Candidate Ingredients for Edible Coatings to Control Decay in ‘Wonderful’ Pomegranate

2021

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This study determined the antimicrobial and antioxidant activity of lemongrass (LO), thyme (TO), and oregano (OO) essential oils and ethanolic extracts of pomegranate peel (PPE) and grape pomace (GPE) as candidate ingredients for edible coatings. Antifungal effects against Botrytis cinerea and Penicillium spp. were tested using paper disc and well diffusion methods. Radical scavenging activity (RSA) was evaluated using 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid assays. Gas chromatography-mass spectrometry analysis identified limonene (16.59%), α-citral (27.45%), β-citral (27.43%), thymol (33.31%), paracymene (43.26%), 1,8-cineole (17.53%), and trans-caryphellene (60.84%) as major compounds of the essential oils. From both paper disc and well diffusion methods, LO recorded the widest zone of inhibition against tested microbes (B. cinerea and Penicillium spp.). The minimum inhibitory concentrations of LO against B. cinerea and Penicillium spp., were 15 µL/mL and 30 µL/mL, respectively. The highest (69.95%) and lowest (1.64%) RSA at 1 mg/mL were recorded for PPE and OO. Application of sodium alginate and chitosan-based coatings formulated with LO (15 or 30 µL/mL) completely inhibited spore germination and reduced the decay severity of ‘Wonderful’ pomegranate. Lemongrass oil proved to be a potential antifungal agent for edible coatings developed to extend shelf life of ‘Wonderful’ pomegranate.

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Section: Discussionmentioning

confidence: 78%

A Comparative Study of Antimicrobial and Antioxidant Activities of Plant Essential Oils and Extracts as Candidate Ingredients for Edible Coatings to Control Decay in ‘Wonderful’ Pomegranate

2021

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“…Biopolymers, such as sodium alginate and gelatin, are interesting materials for wound healing because they are biocompatible, biodegradable, and bioabsorbable [6]. Sodium alginate is a natural polymer derived from brown algae Phaeophyta, formed by monomers of residues of L-guluronic acid and D-mannuronic present in the cell wall and intercellular space [7].…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo

et al. 2020

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Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report the development of a hydrogel composed of natural polymers (sodium alginate and gelatin) and silver nanoparticles (AgNPs) with recognized antimicrobial activity for healing cutaneous lesions. For the development of the hydrogel, different ratios of sodium alginate and gelatin have been tested, while different concentrations of AgNO3 precursor (1.0, 2.0, and 4.0 mM) were assayed for the production of AgNPs. The obtained AgNPs exhibited a characteristic peak between 430–450 nm in the ultraviolet-visible (UV–Vis) spectrum suggesting a spheroidal form, which was confirmed by Transmission Electron Microscopy (TEM). Fourier Transform Infra-red (FT–IR) analysis suggested the formation of strong intermolecular interactions as hydrogen bonds and electrostatic attractions between polymers, showing bands at 2920, 2852, 1500, and 1640 cm−1. Significant bactericidal activity was observed for the hydrogel, with a Minimum Inhibitory Concentration (MIC) of 0.50 µg/mL against Pseudomonas aeruginosa and 53.0 µg/mL against Staphylococcus aureus. AgNPs were shown to be non-cytotoxic against fibroblast cells. The in vivo studies in female Wister rats confirmed the capacity of the AgNP-loaded hydrogels to reduce the wound size compared to uncoated injuries promoting histological changes in the healing tissue over the time course of wound healing, as in earlier development and maturation of granulation tissue. The developed hydrogel with AgNPs has healing potential for clinical applications.

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“…There was also a greater effect on the Gram-negative E. coli than the Gram-positive L. monocytogenes . Similar to the study by Shankar et al, Acharya et al developed AgNPs alongside alginate and gelatin hydrogel films . They were tested against several bacterial strains, including S. typhus , Pseudomonas aeruginosa , E. coli , and S. aureus , and it was found that the Gram-negative bacteria strains were more affected by the composites than the Gram-positive bacteria.…”

Section: Exploiting the Inherent Antimicrobial Nature Of Agnpsmentioning

confidence: 92%

“…Similar to the study by Shankar et al, Acharya et al developed AgNPs alongside alginate and gelatin hydrogel films. 116 They were tested against several bacterial strains, including S. typhus, Pseudomonas aeruginosa, E. coli, and S. aureus, and it was found that the Gram-negative bacteria strains were more affected by the composites than the Grampositive bacteria.…”

Section: Acs Applied Nano Materialsmentioning

confidence: 99%

Silver-Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer

Foulkes

Asgari

Curtis

et al. 2019

ACS Appl. Nano Mater.

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Pancreatic cancer is an extremely aggressive disease for which patient prognosis is poor and survival is extremely unlikely. It is an extremely under-represented cancer in the research field, due to the dense tumors formed and complexities surrounding treatment requirements. The use of nanomedicines in cancer therapy has been explored over the past few decades. Such nanomedicines are slowly coming to fruition in the clinical setting. One such platform which may possess promise in the fight against pancreatic cancer is the use of colloidal silver. Silver nanoparticles have shown potential in other cancer types over a host of treatment strategies and these are likely to be translatable into pancreatic cancer. This review will focus on the potential use of silver nanoparticles in pancreatic cancer therapy, reporting on a range of different strategies being employed which may be directly applicable in improving the clinical outcomes for pancreatic cancer patients.

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Physicochemical and antimicrobial properties of sodium alginate/gelatin-based silver nanoformulations

Cited by 20 publications

References 56 publications

A Comparative Study of Antimicrobial and Antioxidant Activities of Plant Essential Oils and Extracts as Candidate Ingredients for Edible Coatings to Control Decay in ‘Wonderful’ Pomegranate

A Comparative Study of Antimicrobial and Antioxidant Activities of Plant Essential Oils and Extracts as Candidate Ingredients for Edible Coatings to Control Decay in ‘Wonderful’ Pomegranate

Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo

Silver-Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer

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