Pancreatic cancer is an extremely aggressive disease for which patient prognosis is poor and survival is extremely unlikely. It is an extremely under-represented cancer in the research field, due to the dense tumors formed and complexities surrounding treatment requirements. The use of nanomedicines in cancer therapy has been explored over the past few decades. Such nanomedicines are slowly coming to fruition in the clinical setting. One such platform which may possess promise in the fight against pancreatic cancer is the use of colloidal silver. Silver nanoparticles have shown potential in other cancer types over a host of treatment strategies and these are likely to be translatable into pancreatic cancer. This review will focus on the potential use of silver nanoparticles in pancreatic cancer therapy, reporting on a range of different strategies being employed which may be directly applicable in improving the clinical outcomes for pancreatic cancer patients.
Introduction. This study aimed to investigate safety climate and its structural dimensions as well as establish a relationship between safety climate and demographic variables in a power distribution company. Method. This cross-sectional study included 200 workers. The safety climate questionnaire recommended by the UK Health and Safety Executive was applied containing 43 questions in 11 dimensions. Demographic information was also assessed. SPSS version 22.0 was applied to analyze the data. Results. In total, 179 workers participated in this survey. The response rate was high (89.5%). Safety climate had the highest correlation with the management commitment dimension (r = 0.754). The total score of safety climate in this company was 3.37 on a scale ranging from 1 to 5. Among safety climate factors, the highest score was for safety-related training (3.87) but work pressure had the lowest score (2.80). Among demographic variables, a significant relationship was observed between safety climate and age (r = 0.180). Conclusions. Management as an organizational power can exert great influence on the promotion of safety climate. Moreover, adopting efficient training programs and making a balance in workload for decreasing work pressure can improve safety climate.
Objectives:Separate exposure to microwaves (MWs) or heat had effects on expression levels of Bax and Bcl-2 and sperm parameters in studied group.Aims:The objectives of this research were to determine the effects of separate and combined exposure to 900-MHz MW (as representative of cell phone radiation) and heat on gene expression and spermogram of male mice.Settings and Design:This experimental animal study was conducted in the school of public health.Materials and Methods:The study was done on 12 male mice randomly divided into four groups (21–23 g): control, test group 1 with separate exposure to 900-MHz MW, test group 2 with separate exposure to hot and sultry climate, and test group 3 with simultaneous whole body exposures to 900-MHz MW and hot and sultry climate. In all studied groups, gene expression and sperm parameters were measured.Results:Tissue samples in all test groups showed integrity of the seminiferous tubule followed by all types of germ line cells. Significant increases in the number of dead sperms in mice with separate exposure to heat were observed in comparison with the other studied groups (P < 0.05). The ratio of Bax expression was elevated to 0.015 ± 0.006 in mice after combined exposures to 900-MHz MW and heat.Conclusion:Separate and combined exposure to 900-MHz MW and heat may induce adverse effects on sperm parameters and gene expression of studied male mice.
Background: Mineral oils, a complex mixture of chemicals, are primarily used in metalworking processes. Due to different toxicity levels found in mineral oils, two threshold limit values are given for the evaluation of mists of highly and poorly refined mineral oil.
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