Physico-mechanical properties of wound dressing material and its biomedical application

Zaman, Haydar U.; Islam, Jahid M. M.; Khan, Manzoor Ahmed; Khan, Ruhul A.

doi:10.1016/j.jmbbm.2011.05.007

Cited by 89 publications

(34 citation statements)

References 13 publications

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“…This feature explained that the developed films in this study possesses elasticity after the stretching of about 34.6-53.8% recovery in length. Similar findings were also given by Zaman et al [45], Rezvanian et al [6], and Rezvanian et al [46], and it was found that tensile strength value of a dressing was decreased when there was a rise of elongation percentage.…”

Section: Discussionsupporting

confidence: 88%

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Tan

Arulselvan

et al. 2020

BioMed Research International

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Chronic wounds represent serious globally health care and economic issues especially for patients with hyperglycemic condition. Wound dressings have a predominant function in wound treatment; however, the dressings for the long-lasting and non-healing wounds are still a significant challenge in the wound care management market. Astonishingly, advanced wound dressing which is embedded with a synthetic drug compound in a natural polymer compound that acts as drug release carrier has brought about promising treatment effect toward injured wound. In the current study, results have shown that Vicenin-2 (VCN-2) compound in low concentration significantly enhanced cell proliferation and migration of HDF. It also regulated the production of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α from HDF in wound repair. Treatment of VCN-2 also has facilitated the expression of TGF-1β and VEGF wound healing maker in a dose-dependent manner. A hydrocolloid film based on sodium alginate (SA) incorporated with VCN-2 synthetic compound which targets to promote wound healing particularly in diabetic condition was successfully developed and optimized for its physico-chemical properties. It was discovered that all the fabricated film formulations prepared were smooth, translucent, and good with flexibility. The thickness and weight of the formulations were also found to be uniform. The hydrophilic polymer comprised of VCN-2 were shown to possess desirable wound dressing properties and superior mechanical characteristics. The drug release profiles have revealed hydrocolloid film, which is able to control and sustain the VCN-2 released to wound area. In short, hydrocolloid films consisting of VCN-2 formulations are suitably used as a potential wound dressing to promote restoration of wound injury.

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Section: Discussionsupporting

confidence: 88%

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Tan

Arulselvan

et al. 2020

BioMed Research International

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“…Furthermore, in both studies, the mechanical properties of the hybrid films were significantly improved. This is of interest when considering applications such as wound dressing, where flexibility and tensile strength are crucial [78]; or in the regeneration of tissue such as cartilage and/or bone, where the mechanics of the environment plays a key role in the regeneration of the tissue [79,80]. Jiang and Teng [41] explored the use of AgNWs loaded on a polydimethylsiloxane (PDMS) films and their resultant antibacterial activity and human cell compatibility with the aim of developing effective antibacterial coatings to address the global problem of surface microbial contamination above all in secondary care settings.…”

Section: Surface Coating Of Medical Devicesmentioning

confidence: 99%

Silver Nanowires: Synthesis, Antibacterial Activity and Biomedical Applications

2018

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Abstract:Silver is well known for its antibacterial properties and low toxicity, and it is currently widely used both in the form of ions and of nanoparticles in many diverse products. One-dimensional silver nanowires (AgNWs) have the potential to further enhance the properties of nanosilver-containing products, since they appear to have higher antimicrobial efficacy and lower cytotoxicity. While they are widely used in optics and electronics, more studies are required in order to better understand their behavior in the biological environment and to be able to advance their application in uses such as wound healing, surface coating and drug delivery.

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“…Желатин, сшитый полиэтиленгликолем Gelating, sewed with polyethylene glycol [23] Таблица 3. Раневые покрытия на основе целлюлозы и ее производных…”

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Polymers in the Treatment of Wounds: Realities and Perspectives

Legonkova¹,

Belova²,

Асанова³

et al. 2016

jour

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Physico-mechanical properties of wound dressing material and its biomedical application

Cited by 89 publications

References 13 publications

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Healing Effect of Vicenin-2 (VCN-2) on Human Dermal Fibroblast (HDF) and Development VCN-2 Hydrocolloid Film Based on Alginate as Potential Wound Dressing

Silver Nanowires: Synthesis, Antibacterial Activity and Biomedical Applications

Polymers in the Treatment of Wounds: Realities and Perspectives

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