Physico Chemical Methods in Pharmaceutical Chemistry I. Spectrofluorometry

The Fluorescence Spectroscopy of the Hydroxyskatoles and Their Hydrogen Sulfate Esters

“…However, it has recently been claimed that 4-and 7-hydroxyindole fluoresce when activated in the 288-290 my range (9). Under these conditions solutions of 4-and 7-hydroxyindole in methanol showed maximum fluorescence a t 312 mp and 315 my respectively (9). So far, very few investigators have described work which deals with the fluorescence characteristics of the hydrogen sulfate esters of the hydroxyindoles.…”

“…3630 my, while the corresponding 4-and 7-hydrsxytryptamines and 7-hydroxy-3-indolylacetic acid apparently did not fluoresce under these conditions (8). However, it has recently been claimed that 4-and 7-hydroxyindole fluoresce when activated in the 288-290 my range (9). Under these conditions solutions of 4-and 7-hydroxyindole in methanol showed maximum fluorescence a t 312 mp and 315 my respectively (9).…”

“…There have been numerous reports in the literature, in recent years, which deal with the fluorescence characteristics of a number sf 5-hydroxyindole derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). However, relatively little information about the fluorescence properties of other hydroxyindole derivatives (i.e.…”