Physico-chemical characterization of interactions between erythromycin and various film polymers

Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine

“…Several groups have investigated homo‐ and copolymer films for local administration of chemotherapy 5,8. For our studies, we focused on PBLA, PCL, PLA films as possible implant systems for the local delivery of Ellipticine.…”

“…Because each drug has its own unique chemical and physical properties, no delivery vehicle prepared from a particular polymer will serve as a universal carrier for all drugs. The degree of compatibility between polymer and drug has been shown to be of importance in the design of a wide range of delivery systems including block copolymer micelles,1,2 nano or microparticles,3 films,4,5 and gels 6. Specifically, compatibility or degree of interaction between polymer and drug affects many of the performance‐related characteristics of the delivery system such as stability, drug‐loading capacity, drug‐loading efficiency, and drug release kinetics.…”

Influence of solvents on the variety of crystalline forms of erythromycin

“…A number of studies on these forms have been reported. [4][5][6][7][8][9][10][11] At the same time, a literature review showed that similar information on commercially marketed lots of Em raw material is often lacking, and significant variations in the physical properties of the bulk drug are encountered among material supplied by some manufacturers and among different lots supplied by the same manufacturer. 6 Additionally, the intricate molecular structure of Em (Figure 1) suggests the variety of possible supramolecular motifs in crystals, resulting in the formation of different polymorphic modifications.…”

Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets

“…As PEO are a non-ionic material, interaction between drug and polymers is less likely to take place other than hydrogen bonding (H bond) . Study by Sarisuta et al (1999) revealed that erythromycin molecule and non-ionic HPMC polymer chain would probably interact through hydrogen bonding [31]. Moreover, computer simulation by Kiss et al (2008) showed that the interaction between theophylline and poly (ethylene oxide) is stronger and the energy gain of the H bond between these two molecules is greater than in the case of metronidazole.…”