Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine

Liu, Jubo; Xiao, Yazhong; Allen, Christine

doi:10.1002/jps.10533

Cited by 327 publications

(251 citation statements)

References 33 publications

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“…According to LIU et al (2004) the presence of shifts or changes in the polymer-drug spectrum is an indication that they are chemically interacting. DEV et al (2010) encapsulated lamivudine in PLA and chitosan nanoparticles and compared the FTIR spectra of black nanoparticles to nanoparticles containing the drug.…”

Section: Resultsmentioning

confidence: 99%

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

et al. 2015

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The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV RESUMO A encapsulação de progesterona em nanopartículas de poli (hidroxibutirato-co-hidroxivalerato) (PHBV), poli (ε-caprolactona) (PCL), poli (L-ácido lático) (PLLA) e em nanopartículas blenda de PHBV/PCL e PHBV

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Section: Resultsmentioning

confidence: 99%

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

et al. 2015

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“…Peaks corresponding to the melting endotherm of pure famotidine, pure TKP and xanthan were observed on the DSC thermograms of crushed tablets ( Figure 7) and there was no significant change in melting point of the drug and powders in crushed tablets and no other appreciable peak was observed. This indicated that there was no interaction between famotidine and the polymers, meaning that the drug and the polymers were compatible [26].…”

Section: Evaluation Of Prepared Matrix Tabletsmentioning

confidence: 99%

Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine

et al. 2014

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Abstract:The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time.

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“…Achievement of this high drug loading level highlights the influence of drug-excipient compatibility as demonstrated in previous studies. 41 Over 30 days, the GA-mPEG 2000 micelle solution remained clear and transparent, and the average size and PDI did not change significantly (Figure 3). Therefore, conjugating gambogic acid with biocompatible water-soluble mPEG 2000 resulted in a homogeneous and stable dosage form in aqueous solution with high drug loading and a small particle size, which makes gambogic acid more suitable for intravenous administration.…”

Section: Discussionmentioning

confidence: 98%

Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles

Cai¹,

Qiu²,

Xiang³

et al. 2013

IJN

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The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1 H nuclear magnetic resonance. The GA-mPEG 2000 conjugates self-assembled to form nanosized micelles, with mean diameters of less than 50 nm, and a very narrow particle size distribution. The properties of the GA-mPEG 2000 micelles, including morphology, stability, molecular modeling, and drug release profile, were evaluated. MTT (3-(4,5-dimethylthiazo l-2-yl)-2,5 diphenyl tetrazolium bromide) tests demonstrated that the GA-mPEG 2000 micelle formulation had obvious cytotoxicity to tumor cells and human umbilical vein endothelial cells. Further, GA-mPEG 2000 micelles were effective in inhibiting tumor growth and prolonged survival in subcutaneous B16-F10 and C26 tumor models. Our findings suggest that GA-mPEG 2000 micelles may have promising applications in tumor therapy.

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Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine

Cited by 327 publications

References 33 publications

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine

Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles

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