Physico-chemical characterization and biological studies of newly synthesized metal complexes of an Ionic liquid-supported Schiff base: 1-{2-[(2-hydroxy-5-bromobenzylidene)amino]ethyl}-3-ethylimidazolium tetrafluoroborate

Abstract

Co(II), Ni(II) and Cu(II) complexes of an ionic liquid-supported Schiff base 1-{2-[(2-hydroxy-5bromobenzylidene)amino]ethyl}-3-ethylimidazolium tetrafluoroborate were synthesized and characterized by various analytical and spectroscopic methods such as elemental analysis, UV-Visible, FT-IR, 1 H NMR, ESI MS, molar conductance and magnetic susceptibility measurements. Based on the spectral studies, tetra coordinated geometry was proposed for the complexes and molar conductance of the complexes revealed their electrolytic nature. The synthesized Schiff base and its complexes were evaluated for in vitro antibacterial activities against Gram positive and Gram negative bacteria. The complexes along with the Schiff base showed very significant biological activity against the tested bacteria.

Synthesis, characterization and computational study on potential inhibitory action of novel azo imidazole derivatives against COVID-19 main protease (Mpro: 6LU7)

“…Analytical grade solvents and reagents (Sd fine chemical company India and Sigma Aldrich) were used without further purification for the synthesis of azo imidazole derivatives. The azo aldehyde precursors and amino functionalized imidazole were prepared by following the literature procedure [44] , [45] , [46] , [47] . The IR spectra of the synthesized compounds were measured using Perkin-Elmer Spectrum FT-IR spectrometer (RX-1) in KBr pellets.…”

“…Red solid. Yield: 64%, (IR, KBr cm −1 ); 3200–3428 (O—H), 1645 ( C = N ), 1608 ( C = C ), 1548, 1511 ( N = N ), 1384, 1258 (C—O), 1170, 970 ( N = N , bending); 840 (PF 6 ) 1 H NMR (300 MHz, d 6 -DMSO, ppm): δ 3.70 (s, 3H, NCH 3 ), 2.35 (s,3H, CH 3 ), 3.96 (s, 3H, OCH 3 ), 4.56 (t, 2H, N—CH 2 J 1 =5.4 Hz, J 2 =5.40 Hz), 4.04 (t, 2H, N—CH 2 , J 1 =5.7 Hz, J 2 =5.10 Hz), 7.66 (s, 1H, NCH), 7.76 (s, 1H, NCH), 9.17 (s, 1H, N(H) CN), 8.61 (s, 1H, HC N ), 13.4 (s, 1H, broad, OH), 7.29–7.83 (m, 6H, Ar-H)) [ [46] , [47] , [59] , [60] ]. Anal.…”

A new nano‐sized mononuclear Cu (II) complex with N,N‐donor Schiff base ligands: sonochemical synthesis, characterization, molecular modeling and biological activity

“…The molecular conductivity (Λm) of the (10 −4 M) solution of metal complexes at room temperature was measured using the well‐known relation Λm = 1000 × κ/c, which c is the solution concentration, and κ is the specific conductivity of the solution (κ = difference in conductivity reads for complex and DMSO solvent conductivity). The conductance values were in the range of 180 and 186 S.mol −1 .cm 2 , respectively, for the bulk and nano copper complexes, showing their 1:2 (M:L) electrolytic behavior …”

Anticancer activity studies of novel metal complexes of ligands derived from polycyclic aromatic compound via greener route

“…respectively, of supplementary material) shows one broad peak due to spin-allowed d-d transition centered at 707 and 717 nm assignable to 2 T 2g 2 E g as is the consequence of distorted octahedral environment around copper (II) ion [36,37]. Table 2 shows the solution electronic absorption spectral data of ligands and their respective metal complexes.…”