Physico-chemical and antifungal properties of protease inhibitors from Acacia plumosa

Lopes, José Luiz de Souza; Valadares, Napoleão Fonseca; Moraes, D. I.; Rosa, José César; Araújo, Heloísa Sobreiro Selistre de; Beltramini, Leila Maria

doi:10.1016/j.phytochem.2009.04.009

Cited by 70 publications

(50 citation statements)

References 38 publications

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“…A wide number of biological activities have been found to be associated with materials isolated from Acacia species including anti-oxidant, -cancer and -microbial effects (Bachaya et al, 2009;Lopes et al, 2009;Tung et al, 2008). Among the various Acacia, A. ferruginea (Mimosaceae) is a deciduous tree whose products have been used to treat pathologies such as hemorrhage, irritable bowel syndrome, leprosy and diarrhea (Kirtikar & Basu, 2003;Parrotta, 2001).…”

Section: Introductionmentioning

confidence: 99%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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Inflammation is a local defensive reaction of a host to cellular injury or infection. Prolonged inflammation can contribute to pathogenesis of many disorders. Identification of naturally occurring phytoconstituents that can suppress inflammatory mediators can lead to the discovery of anti-inflammatory therapeutics. Acacia ferruginea is used traditionally to treat numerous ailments including hemorrhage, irritable bowel syndrome and leprosy. The present study evaluated the anti-inflammatory activity of A. ferruginea extract against acute (carrageenan) and chronic (formaldehyde) inflammation in Balb/c mice. Pre-treatment with A. ferruginea extract (10 mg/kg BW) for 5 consecutive days via intraperitonial (IP) administration significantly inhibited subsequent induction of paw edema in both models; the effects were comparable to that of the standard drug indomethacin. The results also showed the A. ferruginea extract significantly inhibited nitric oxide (NO) synthesis and iNOS expression (as measured in serum), diminished inflammation in -and neutrophil infiltration to -the paw tissues and led to a reduction in the number of COX-2 + immunoreative cells (as evidenced by histologic and immunohistochemical analyses) in the paws relative to those in paws of mice that received the irritants only. Further, in vitro studies showed the extract could significantly scavenge free radicals generated as in DPPH and NO radical generating assays. Taken together, the results showed that A. ferruginea extract imparted potent anti-oxidant and -inflammatory effects, in part by maintaining oxidative homeostasis, inhibiting NO synthesis and suppressing iNOS and COX-2 expression and so could potentially be exploited as a potential plant-based medication against inflammatory disorders.

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Section: Introductionmentioning

confidence: 99%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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“…Various biological activities for Acacia speciescovering a gamut of beneficial properties -have been reported, i.e. it imparts anti-cancer, -oxidant, -helmintic, -microbial effects (Bachaya et al, 2009;Lopes et al, 2009;Meena et al, 2006;Tung et al, 2008). Acacia are a rich natural source of bioactive flavornoids, phenolics, alkaloids, polysaccharides, quinones, saponins, tannins, and terpenoids.…”

Section: Introductionmentioning

confidence: 99%

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Sakthivel

Guruvayoorappan

2014

Journal of Immunotoxicology

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Cyclophosphamide (CTX), commonly used as an anti-neoplastic drug, can cause adverse sideeffects including immunotoxicity and urotoxicity. Increasingly, plants have become sources of therapeutics that can help to restore host immunity to normal. In this study, Acacia ferruginea was assessed for an ability to protect mice against/mitigate CTX-induced toxicity. Coadministration of an extract of A. ferruginea (10 mg/kg BW, IP daily) for 10 consecutive days reduced CTX (25 mg/kg BW, IP daily)-induced toxicity. Apart from improvements in bladder and small intestine morphology, there was marked improvement in anti-oxidant (glutathione) levels in the bladder, suggesting a role for the anti-oxidant in reducing CTX-induced urotoxicity. Moreover, use of the extract significantly increased total leukocyte counts and bone marrow cellularity/-esterase activity in CTX-treated mice which suggested a protective effect on the hematopoietic system. Co-treatment with the extract also prevented decreases in organ (liver, kidney, spleen, thymus) weight as well as body weight, thereby seemingly lessening the potential impact of CTX on the host immune system. Further, CTX-induced increases in serum aspartate transanimase, alanine transaminase, and alkaline phosphatase were reversed by extract co-treatment, as were alterations in in situ formation/release of interferon (IFN)-, interleukin (IL)-2, granulocyte-macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF)-. Overall, this study indicated there were some protective effects from use of an extract of A.ferruginea against CTX-induced toxicities, in part through modulation of levels of anti-oxidants and pro-inflammatory cytokines.

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“…in response to attack by insect pest and pathogens (De Leo et al, 2001) and interfere with the digestion process of insect, affecting the metabolism, disrupting growth and development of the larva (Jadhav et al, 2012a). Among them, protease inhibitors regulate physiological processes through controlling protease activities and are also involved in defense mechanisms in plants ( Kim et al, 2006;Lopes et al, 2009). These proteins interact with their target proteases and form stable protease-inhibitor complexes that are incapable of enzymatic activity (Norton, 1991).…”

Section: Introductionmentioning

confidence: 99%

Insecticidal Potential of Abelmoschus moschatus Trypsin Inhibitor (AMTI-II) Against Mid Gut Protease of Helicoverpa armigera

Kumar¹

2017

IJASR

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Physico-chemical and antifungal properties of protease inhibitors from Acacia plumosa

Cited by 70 publications

References 38 publications

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Acacia ferrugineainhibits cyclophosphamide-induced immunosuppression and urotoxicity by modulating cytokines in mice

Insecticidal Potential of Abelmoschus moschatus Trypsin Inhibitor (AMTI-II) Against Mid Gut Protease of Helicoverpa armigera

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