Physician-reported management of edema and destabilized blood pressure in cyclooxygenase-2-specific inhibitor users with osteoarthritis and treated hypertension

Osterhaus, Jane T.; Burke, Thomas; May, Corey; Wentworth, Chuck; Whelton, Andrew; Bristol, Susan

doi:10.1016/s0149-2918(02)80011-x

Cited by 7 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A chart was developed with drug-drug interactions between anithypertensive medicines and the NPMs reported, and subsequently placed in risk categories ( Table 2) of clinical significance based on documented interactions and outcomes in texts 7-9 and cross-checked with the literature. 5,11,17,19,[26][27][28][29][30][31][32][33][34][35][36] The interactions rated as moderate or high clinical significance were tallied. NPMs that may directly affect blood pressure were identified based on the products' active ingredients and the literature.…”

Section: Methodsmentioning

confidence: 99%

“…The proportion of persons reporting use was significantly higher than those in a similar study 6 in Australia. The use of some NSAIDs in people living with hypertension has been shown to cause changes in blood pressure 11,30,33,34,36 and requires judicious use of these medicines and monitoring of the individual's blood pressure as they are at risk of hypertensive crises and renal damage. However, the effect depends on the NSAID selected, its dosage and its frequency.…”

Section: Hypertension-npm Interactionsmentioning

confidence: 99%

See 1 more Smart Citation

Non-prescription medicine use by outpatients of a hospital in north-central Trinidad living with hypertension, and the potential clinical risks

Extavour

Edwards

2008

International Journal of Pharmacy Practice

View full text Add to dashboard Cite

Objective To describe the reported use of non‐prescription medicines (NPMs) and the reported frequency of use by outpatients living with hypertension; to identify potential drug‐drug and drug‐disease interactions between reported NPMs and either antihypertensives prescribed or hypertension. Setting Adult outpatient clinics of the Eric Williams Medical Sciences Complex Adult Hospital in Trinidad. Method Outpatients were interviewed about their use of NPMs using a structured instrument. Chi‐squared test or Fisher's exact test was used to test for associations between NPM use and selected variables: age group, gender, education level, number of prescribed medicines, use of prescribed medicines and the presence of comorbidities. Combinations of NPMs and antihypertensive drugs or hypertension itself that may lead to undesirable interactions were identified. Key findings One hundred and fifty‐five clients were interviewed (mean age 61 years; 46% men; 56% of East Indian descent). Of these, 82% were living with a cardiac condition and 60% with diabetes mellitus. In addition, 92% reported using NPMs to treat minor illnesses. Analgesic use was reported by 81%. Some 66% reported using paracetamol, 54% reported antitussives, 48% antacids, 47% antihistamines and 39% said they used sympathomimetic drugs. The majority (98%) of NPMs were used only when needed. Sixty per cent had at least one combination a with risk of interaction with NPMs and hypertension or antihypertensive medicines: 16% had risk of interactions between enalapril (or captopril) and antacids, 13% between angiotensin‐converting enzyme (ACE) inhibitors and non‐steroidal anti‐inflammatory drugs (NSAIDs), 12% between beta‐blockers and NSAIDs and 12% between thiazide diuretics and NSAIDs. Thirty‐nine per cent had a drug‐disease interaction risk due to sympathomimetic drugs and 26% had one due to NSAID use. Conclusion Based on self‐reports, outpatients living with hypertension in north‐central Trinidad use NPMs when needed to treat minor illnesses, mainly paracetamol for pain. Non‐prescription‐antihypertensive interactions may arise due to ACE inhibitor/antacid combinations and NPM‐hypertension interactions may result from use of sympathomimetics. Interactions may also arise as a result of the use of NPMs containing NSAIDs and sodium.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Hypertension-npm Interactionsmentioning

confidence: 99%

Non-prescription medicine use by outpatients of a hospital in north-central Trinidad living with hypertension, and the potential clinical risks

Extavour

Edwards

2008

International Journal of Pharmacy Practice

View full text Add to dashboard Cite

show abstract

“…Oedema formation with selective COX inhibitors is dose‐dependent and, similar to nonselective COX inhibitors is associated with clinically significant weight gain in 30–50% of cases [22]. Although oedema was a rare cause for study drop‐out in the large clinical trials VIGOR and CLASS, a recent postmarketing survey noted that the development of oedema led to discontinuation of the COX‐2 inhibitor in 58–82% of cases [23]. Direct comparison of oedema formation between rofecoxib and celecoxib has also been performed in the SUCCESS VI study [24].…”

Section: Electrolyte and Fluid Effects Of Coxibsmentioning

confidence: 99%

Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors

Gambaro

Perazella

2003

Journal of Internal Medicine

188

119

View full text Add to dashboard Cite

. Gambaro G, Perazella MA (Division of Nephrology, University Hospital, Padua, Italy; and Section of Nephrology, Yale University, New Haven, CT, USA). Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors (Review). J Intern Med 2003; 253: 643–652. Conventional nonsteroidal anti‐inflammatory drugs (NSAIDs), i.e. nonselective cyclooxygenase COX inhibitors have well‐documented nephrotoxicity. Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase‐derived prostaglandins which act to modulate pathologic processes that would normally impair various renal functions. The introduction of the selective COX‐2 inhibitors raised hope that this class of drugs would reduce injury in both the gastrointestinal tract and the kidneys. Animal and human data, however, suggest that COX‐2 synthesized prostaglandins are important in the modulation of renal physiology during adverse conditions. Hence, it appears that these drugs are equal in causing nephrotoxicity as the nonselective COX inhibitors.

show abstract

“…31,32 A survey of 215 family practitioners and 151 internists indicated that they would increase the dosage of antihypertensive agent 26-41% of the time when they identified blood pressure destabilization after patients with treated hypertension started a COX-2 inhibitor. 33 Therefore, antihypertensive dosage increases are likely to have important implications with respect to overall costs of care for these patients. Data from other real-world experience provided related signals, such as those reported in a large retrospective cohort study of an employer claims database.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Changes in Blood Pressure Measurements and Antihypertensive Therapy in Older, Hypertensive, Ambulatory Care Patients Prescribed Celecoxib or Rofecoxib

et al. 2003

View full text Add to dashboard Cite

show abstract

Physician-reported management of edema and destabilized blood pressure in cyclooxygenase-2-specific inhibitor users with osteoarthritis and treated hypertension

Cited by 7 publications

References 19 publications

Non-prescription medicine use by outpatients of a hospital in north-central Trinidad living with hypertension, and the potential clinical risks

Non-prescription medicine use by outpatients of a hospital in north-central Trinidad living with hypertension, and the potential clinical risks

Adverse renal effects of anti‐inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors

Comparison of Changes in Blood Pressure Measurements and Antihypertensive Therapy in Older, Hypertensive, Ambulatory Care Patients Prescribed Celecoxib or Rofecoxib

Contact Info

Product

Resources

About