Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Abstract

Background: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory elementbinding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.

Strength training protects against prostate injury in alcoholic rats

“…The expression of genes involved in the synthesis, transport, and metabolism of fatty acids, and cholesterol in the prostate microenvironment is related to androgen activation (Manca et al, 2019). Previous studies carried out by our laboratory have shown that strength or resistance training affects the prostate by promoting hormonal changes and cell turnover (Teixeira et al, 2020). However, it is unclear how changes in circulating lipid and steroid hormone levels induced by long-term alcohol consumption and strength training may affect prostate health, including proliferation, and apoptosis.…”

“…The practice of regular physical exercise with moderate intensity is well known as a nonpharmacological strategy for treating and preventing a range of diseases. Strength training can improve the lipid metabolism of the liver and prostate (dos Santos et al, 2019; Teixeira et al, 2020). As previously reported, both alcohol consumption alone and physical exercise alone have many effects on the prostate.…”

Supplementation of polyunsaturated fatty acids (PUFAs) and aerobic exercise improve functioning, morphology, and redox balance in prostate obese rats

“…We found that omega-3 PUFAs reduced expression of Fas/CD95 and BCL-2, and increased BAX when associated with aerobic physical exercise. It is already well documented that physical exercise promotes alteration of apoptosis in the prostate cell increases the BAX reduce proliferative ratios in the ventral prostate 28 even in animals submitted to a high-fat diet 18 . Thus, it is possible to relate that supplementation of omega-3 PUFAs associated with aerobic exercise promotes prostatic cell apoptosis intrinsically.…”

Physical Exercise Mitigates the Disturbs Caused in Ventral Prostate by High Fat Diet, Clarifying the Role of PPAR-Alpha

“…The absence of PPARα does not interfere with HFDinduced AR activation. On the other hand, aerobic physical exercise has the potential to reduce prostatic changes, as demonstrated by Teixeira et al 25,39 , by reducing the expression of AR. Our results showed lower expression of AR in the groups submitted to aerobic exercise and HFD in both genotypes, with a reduction from 72% (PPARα KO HF) to 44% (PPARα KO HFT) in the incidence of PIN.…”

“…Physical exercise has already been shown to regulate the prostate environment. Data from our laboratory demonstrated that physical training in Wistar rats modulates the lipid and hormonal pro le of the ventral prostate 25,26 and improves body composition, expression of steroid hormone receptors, and cellular apoptosis in the prostate 27,28 . In animals fed with a high-fat diet (HFD) and submitted to strength training, reduced cell proliferation was observed as well as an increase in hormone receptors, modifying prostatic homeostasis 29 .…”