Strength training protects against prostate injury in alcoholic rats

Teixeira, Giovana Rampazzo; Chuffa, Luiz Gustavo de Almeida; Mendes, Leonardo O.; Veras, Allice Santos Cruz; McCabe, James; Fávaro, Wagner José; Pinheiro, Patrícia Fernanda Felipe; Amorim, João Paulo de Arruda; Martins, Otávio Augusto; Mello‐Junior, Wilson; Martinez, Francisco Eduardo

doi:10.1002/jcp.30108

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Interestingly, HIIT executed in SHR rats increased the of BAX and FAS/CD95 and relationship BAX/BCL‐2. These results are consistent with previous evidence that physical exercise increased apoptosis prostatic 10,52 . These findings suggest that the HIIT promote prostate regulation in hypertensive rats by increasing cell apoptosis, both intrinsic and extrinsic pathway.…”

Section: Discussionsupporting

confidence: 93%

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High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

et al. 2021

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Background: The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High-intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR).Methods: Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL-2, BAX, IGF-1, FAS/CD95, data's inflammatory tumour necrosis factor α, nuclear factor kappa B and interleukin (IL)-6, anti-inflammatory IL-10. The echocardiographic evaluation was performed at the baseline and after the training period.Results: Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF-1, BCL-2 (p < 0.05), and inflammatory proteins (p < 0.05). Eight weeks of HIIT training reduced the arterial pressure and increase the concentration of tissue collagen and intracellular glycogen and showed a higher expression of BAX, FAS/CD95, and IL-10 proteins (p < 0.05), coinciding with a lower incidence of lesions and lower prostate weight (p < 0.05) and reduction of the BCL-2 and IGF-1. Conclusion:Our data suggested that arterial hypertension suppressed apoptosis and increased damage prostatic. On other hand, HIIT promotes morphology and function improves in the prostatic environment, inhibited inflammation, and increased apoptosis.

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Section: Discussionsupporting

confidence: 93%

“…These results are consistent with previous evidence that physical exercise increased apoptosis prostatic. 10,52 These findings suggest that the HIIT promote prostate regulation in hypertensive rats by increasing cell apoptosis, both intrinsic and extrinsic pathway. Still, the HIIT intervention increased the GR in the prostate.…”

Section: Discussionmentioning

confidence: 83%

High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

et al. 2021

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“…The immunohistochemistry technique was performed as previously described by our research group (Teixeira et al 2021;Teixeira et al 2020;Veras et al 2021) The sections were subjected to solutions of ImmPRESS Polymer kit (MP-7800) from Vector Laboratories®, for peroxidase and protein blocks. In the next step, the sections were subjected to a reaction with speci c primary antibodies diluted 1:100, BAX (B-9, sc-7480) mouse monoclonal IgG, BCL-2 (C-2, sc-7382), Nuclear factor kappa B, NF-κB (p-65, A, sc-109), interleukin 6, IL-6 (E-4, sc-28343), tumor necrosis factor alpha, TNF-α (52B83, sc-257), androgen receptor, AR (441, sc-7305), and interleukin 10, IL-10 (NYRM, sc-73309), mouse monoclonal IgG, and incubated in a humid chamber overnight.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Aerobic physical exercise enhances nanoparticle efficacy in prostate cancer treatment

Veras,

Batista,

Correia

et al. 2023

Preprint

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The effectiveness of drugs currently employed for prostate cancer (PC) can vary, as they may not always yield satisfactory results. Moreover, resistance to these drugs can develop over time, rendering long-term therapy ineffective, depending on the specific type of cancer. The research and clinical application of drug-carrying nanoparticles in various types of cancers is rapidly expanding. Here, we used a nanoemulsion (LDE) as a carrier of docetaxel (DTX). Nevertheless, our testing has demonstrated that the non-pharmacological effects of aerobic physical exercise can enhance the antitumor effects associated with LDE nanoemulsion in the treatment of PC. Aerobic physical exercise demonstrated a potentiation effect on the internalization of LDE nanoparticles. Notably, when combined with LDE+DTX+EX, it resulted in an increased expression of p-16, p-27, p-53, and p-21 compared to the PC group. The LDE-DTX treatment exhibited significant reductions in prostate weight, protected against adenocarcinomas, decreased proliferation, and downregulated the anti-apoptotic protein BCL-2, while simultaneously increasing the expression of the pro-apoptotic protein BAX and reduction of the inflammation. Additionally, the LDE+DTX+EX group displayed metabolic regulation, as evidenced by reductions in lipids and plasma glucose levels. These findings collectively highlight the potential benefits of combining LDE, docetaxel, and physical exercise, indicating improved therapeutic outcomes and metabolic regulation in prostate cancer. In conclusion, our findings revealed that the combined treatment of LDE-docetaxel and physical exercise led to an increase in tumor suppressor proteins, which had a significant impact on the phenotype of PC.

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Biological responses to imazapic and methyl parathion pesticides in bioinspired lipid membranes and Tilapia fish

Rubira

Batista

Correia

et al. 2023

Journal of Hazardous Materials

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Strength training protects against prostate injury in alcoholic rats

Cited by 5 publications

References 42 publications

High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

Aerobic physical exercise enhances nanoparticle efficacy in prostate cancer treatment

Biological responses to imazapic and methyl parathion pesticides in bioinspired lipid membranes and Tilapia fish

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