Physical properties of PLGA films during polymer degradation

Houchin, M.L.; Topp, Elizabeth M.

doi:10.1002/app.30813

Cited by 107 publications

(71 citation statements)

References 35 publications

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“…PLGA is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA). The physical properties of the polymer depend upon multiple factors, including the initial molecular weight, the relative ratio of the polymeric monomers, the exposure to water (surface shape) and storage temperature (Houchin and Topp, 2009). For its suitability and long clinical experience, PLGA, can be considered the most popular biodegradable polymer.…”

Section: Introductionmentioning

confidence: 99%

“…For its suitability and long clinical experience, PLGA, can be considered the most popular biodegradable polymer. Various polymeric devices like microspheres, microcapsules, nanoparticles, pellets, implants and films have been fabricated using these polymer (Cheng et al, 2007;Esmaeili et al, 2008;Fan et al, 2012;Houchin and Topp, 2009;Li et al, 2001;Makadia and Siegel, 2011;Wischke and Schwendeman, 2008). PLGA has been mostly formulated into delivery systems for vehicle different drug classes, such as vaccines, peptides, proteins and micro-molecules (Li et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

D’Apolito

Taraballi

Minardi

et al. 2016

Medical Engineering & Physics

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Blood is a complex biological fluid composed of deformable cells and platelets suspended in plasma, a protein-rich liquid. The peculiar nature of blood needs to be considered when designing a drug delivery strategy based on systemically administered carriers. Here, we report on an in vitro fluid dynamic investigation of the influence of the microcapillary flow of red blood cells (RBCs) on micron sized carriers by high speed imaging methods. The experiments were carried out in a 50 m diameter glass capillary that mimicked the hydrodynamic conditions of human microcirculation. Spherical particles (-Ps), with sizes ranging between 0.5 and 3 m, were tested. Images of the flowing RBCs and -Ps were acquired by a highspeed/high-magnification microscopy. The transport and distribution of rigid particles in a suspension of RBCs under shear flow were followed for: i) the migration of RBCs towards the vessel centerline due to their deformability; ii) the cross-flow migration of -Ps towards the vessel wall due to their hydrodynamic interactions with RBCs; iii) the radial distribution of Ps in the presence of RBCs. This study suggests that the therapeutic efficacy of Ps could be ultimately affected by their interactions with the flowing RBCs in the vasculature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

D’Apolito

Taraballi

Minardi

et al. 2016

Medical Engineering & Physics

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“…And the modification of PLGA properties during polymer biodegradation were influenced with the release and degradation rates due to water moisture degradation. The Gordon-Taylor equation has been used to relate glass transition temperature and water content in PLGA within narrow range of moisture content and limited polymer degradation [12][13][14][15] The aim of this study was to evaluate this plates and screws with using a injection molding concerning its basic properties and biocompatibility. The obtained plates and screws were observed with scanning electron SEM, DSC, TGA, NMR, XRD, bending moment and tensile strengths.…”

Section: Introductionmentioning

confidence: 99%

A Study on Surface, Thermal and Mechanical Properties of Absorbable PLGA Plate

Park¹,

Kang²

2013

IJCA

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“…Polymer degradation generates low molecular weight species and other degradation products, which decreases T g according to the Flory-Fox equation and from previous studies of PLGA degradation. 13,27 Notation ''NA'' means an endotherm was not observed.…”

Section: In Vitro Degradation and Drug Elutionmentioning

confidence: 52%

Morphological and degradation studies of sirolimus‐containing poly(lactide‐co‐glycolide) discs

Ro¹,

Falotico²,

Davé³

2011

J Biomed Mater Res

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The effect of residual solvent and copolymer ratio on the in vitro degradation and drug release behavior of a bioabsorbable polymer/drug system was investigated in an effort to understand and develop the use of these excipients for controlled drug delivery devices. Sirolimus-containing poly(lactide-co-glycolide) (PLGA) discs were fabricated by a solution-casting method using dimethyl sulfoxide (DMSO) as the solvent. The residual DMSO was removed from a set of discs by supercritical carbon dioxide extraction, and reflections of crystalline sirolimus were observed in the wide-angle X-ray scattering profile observed after extraction. A correlation was not observed between the extent of drug crystallization and extraction conditions and copolymer ratio. Mass loss, molecular weight, and sirolimus release were monitored during an in vitro study of the oven-dried neat PLGA, sirolimus-containing PLGA, and extracted sirolimus-containing PLGA discs during 56 days. The sirolimus-containing PLGA discs with residual DMSO exhibited a faster sirolimus release rate compared to the extracted discs. The residual DMSO facilitated release of sirolimus. The discs that contained PLGA with higher glycolide content, particularly 50% glycolide, degraded faster and exhibited faster sirolimus release.

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Physical properties of PLGA films during polymer degradation

Cited by 107 publications

References 35 publications

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques

A Study on Surface, Thermal and Mechanical Properties of Absorbable PLGA Plate

Morphological and degradation studies of sirolimus‐containing poly(lactide‐co‐glycolide) discs

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