Physical, mechanical, and transdermal diltiazem release analysis of nanosilica tailored various poly(vinyl alcohol) membranes

Abstract

Hybrid membranes based on poly(vinyl alcohol) (PVA) of widely different molecular weights and ex situ nanosilica were synthesized and characterized as transdermal delivery device for Diltiazem hydrochloride. Investigations showed that change in PVA molecular weight strongly influenced physico‐mechanicals of the hybrids especially at low nanosilica content than at higher levels. As for example at 1 wt %, low molecular weight PVA induced finer dispersion of silica nanoparticles resulting into higher dry state crystallinity and mechanical strength but slightly lower biocompatibility as compared to high molecular weight PVA. Those variations in physico‐mechanicals finally affected Diltiazem retention and its elution from those membranes under physiological conditions. Low molecular weight PVA produced highest drug retention as well as slowest yet steady release than both high molecular weight PVA and neat PVA membranes. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2076–2086, 2013

Untitled

“…PVA hydrogels with 3.0 % dodecylamine showed the best results. Bhunia et al evaluated the ability of PVA incorporated with nanosilica to deliver diltiazem hydrochloride across the skin [9]. Tensile measurements displayed that a variation in molecular weight of PVA markedly affected the mechanical properties of the film mainly at low filler concentration compared to high concentration.…”

A transdermal device from 2-hydroxyethyl methacrylate grafted carboxymethyl guar gum–multi-walled carbon nanotube composites

“…The mentioned parameters are the essential requirements for "patch therapy" as well. [14][15][16][17][18][19][20][21][22][23][24] However conceding the recent environmental awareness, the modern scientic community is inclined towards examination with natural polysaccharides and other bio molecules for similar and other biomedical applications. [25][26][27][28] But poor cohesive strength, occasionally has been found to be their major disadvantage despite high molecular weight and crystallinity.…”