Nanocomposite for transdermal drug delivery

Parhi, Rabinarayan

doi:10.1016/b978-0-12-813741-3.00016-9

Cited by 10 publications

(11 citation statements)

References 123 publications

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“…One of the most important advantages might be their ability to encapsulate imaging and therapeutic agents due to their liquid core. A much wider range of therapeutic and imaging agents can be coloaded (i.e., on its shell and/or in its core) including those that are insoluble and otherwise would not be able to be attached to the surface of solid nanoparticles due to chemical sensitivity with the surrounding hydrophilic environment (Ai & Mohammad, 2018;Azmi, Elgharbawy, Motlagh, Samsudin, & Salleh, 2019;Debnath, Satayanarayana, & Gampa, 2011;Tiwari, Shenoy, & Amiji, 2006). This not only has the potential to improve the theranostic capabilities but also can improve the bioavailability and ability of nanoparticles to be used for long term imaging and therapy.…”

Section: List Of Tablesmentioning

confidence: 99%

Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging

Fernandes

2023

Preprint

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Nanoemulsions have been used as theranostic agents for both imaging cancer and therapy by the ability of perfluorocarbon nanoemulsions to vaporize. However, many of the current imaging contrast agents are not stable enough to be used for long term monitoring of tumor growth/regression during therapy. The current work uses biocompatible perfluorohexane nanoemulsions (PFH-NEs) with silica coated gold nanoparticles (scAuNPs) (PFH-NEs-scAuNPs) that can be used to enhance both the photoacoustic (PA) as well as the nonlinear ultrasound (NL US) signals from the resulting PFH bubbles formed from laser excitation. Results show the ability of PFH-NEs-scAuNPs to be used for imaging of cancer using various imaging platforms (i.e., photoacoustic, nonlinear ultrasound, fluorescence) as well as for destroying cancer cells through vaporization of PFH-NEs. Compared to other conventional PA and NL US contrast agents, the signals from PFH-NEs-scAuNPs are more stable with the added benefit that they can be used effectively to treat different tumors through efficient encapsulation of different therapeutic agents and vaporization. In vivo results show that the signals from PFH-NEs and PFH bubbles are stable for several days where the nanoparticles can be used for their theranostic ability to efficiently localize and treat cancer, serving to improve outcomes in cancer and showing strong potential for clinical applications.

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Section: List Of Tablesmentioning

confidence: 99%

Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging

Fernandes

2023

Preprint

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“…Therefore, incorporating nanofillers with magnetic properties is an excellent solution to improve the characteristics of the NCs. Nanosized particles of ferromagnetic and ferrimagnetic materials have been incorporated into extended matrix materials to create integrated functional systems with additional magnetic properties [78].…”

Section: Magnetic Polymer Nanocompositesmentioning

confidence: 99%

Polymer-Magnetic Semiconductor Nanocomposites for Industrial Electronic Applications

et al. 2022

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Nanocomposite materials have acquired great importance, as have similar composite materials on a macroscopic scale, because the reinforcement complements the defects in the properties of the matrix, thus obtaining materials with better mechanical, thermal, and electrical properties, among others. At the same time, the importance and research of polymeric nanocomposites reinforced with nanoparticles of various types have grown. Among those that have stood out the most in the electronics industry are polymeric matrices reinforced with nanoparticles that present dual behavior, that is, both magnetic and semiconductor. This property has been very well used in developing electronic devices such as televisions, computers, and smartphones, which are part of everyday life. In this sense, this review presents a compilation of the synthetic methods to produce polymer nanocomposites with dual magnetic and semiconductor behavior and their potential applications within electronic fields and new relevant trends.

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“…Studies related to nanotechnology have increased in the last years due to its versatility when applied in medicine. Nanocomposites have two parts: (1) a continuous phase and (2) a discontinuous or reinforcing phase [6]. PNCs consist of a polymer matrix as continous phase, with a nanoscale (more specifically less than 100 nm in size) reinforcing dispersed phase [7].…”

Section: Polymer Nanocompositesmentioning

confidence: 99%

“…Data analysis is much easier in magnetic nanocomposites containing particles of uniform size [104]. Nanosized particles of ferromagnetic and ferromagnetic materials have been incorporated into extended matrix materials to create integrated functional systems with additional magnetic properties [6]. Magnetic nanocomposites exhibit superparamagnetic behavior, which is a property highly recommended for biomedicine, through the use of an external magnetic field and thus the treating of complex diseases [10].…”

Section: Magnetic Nanocompositesmentioning

confidence: 99%

Interaction between Filler and Polymeric Matrix in Nanocomposites: Magnetic Approach and Applications

et al. 2021

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In recent years, polymer nanocomposites produced by combining nanofillers and a polymeric matrix are emerging as interesting materials. Polymeric composites have a wide range of applications due to the outstanding and enhanced properties that are obtained thanks to the introduction of nanoparticles. Therefore, understanding the filler-matrix relationship is an important factor in the continued growth of this scientific area and the development of new materials with desired properties and specific applications. Due to their performance in response to a magnetic field magnetic nanocomposites represent an important class of functional nanocomposites. Due to their properties, magnetic nanocomposites have found numerous applications in biomedical applications such as drug delivery, theranostics, etc. This article aims to provide an overview of the filler-polymeric matrix relationship, with a special focus on magnetic nanocomposites and their potential applications in the biomedical field.

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Nanocomposite for transdermal drug delivery

Cited by 10 publications

References 123 publications

Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging

Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging

Polymer-Magnetic Semiconductor Nanocomposites for Industrial Electronic Applications

Interaction between Filler and Polymeric Matrix in Nanocomposites: Magnetic Approach and Applications

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