Physical interpretation of parameters in the Rosin-Rammler-Sperling-Weibull distribution for drug release from controlled release dosage forms

Christensen, Finn Norring; Hansen, Flemming Yssing; Bechgaard, Helle

doi:10.1111/j.2042-7158.1980.tb13002.x

Cited by 37 publications

(19 citation statements)

References 3 publications

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“…The metoprolol data, as well as the data of ibuprofen described in Experimental Data that follows, were fitted with the modified Weibull [Eq. (9) or (10)] and the simple Weibull [Eq. (3)].…”

Section: Methodsmentioning

confidence: 99%

“…(3)] is equivalent to the physically relevant modified versions Eqs. (9) and (10). This is so because…”

Section: Theorymentioning

confidence: 98%

“…Equation (3) has been applied extensively and successfully in the analysis of a great number of dissolution studies (5Y7). Because of the empirical use of the Weibull function in dissolution studies, criticism ranging from the lack of a kinetic basis for its use to the nonphysical nature of the parameters has been reported (8,9). In this study, we focus on the proper use of the NoyesYWhitney and Weibull equations for the analysis of dissolution data using branched versions of them, which reach plateau either at infinite or finite time.…”

Section: Introductionmentioning

confidence: 98%

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A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

2006

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Section: Methodsmentioning

confidence: 99%

“…(3)] is equivalent to the physically relevant modified versions Eqs. (9) and (10). This is so because…”

Section: Theorymentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

2006

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“…Por este ser um modelo empírico, apresenta algumas deficiências e tem sido alvo de algumas críticas (Pedersen, Myrick, 1978;Christensen, Hansen, Bechgaard, 1980), tais como não ter qualquer fundamento cinético e poder apenas descrever, mas não caracterizar adequadamente, as propriedades cinéticas de dissolução de um fármaco, não conter um parâmetro que dê uma idéia da velocidade de dissolução intrínseca do fármaco e não ajudar a estabelecer correlações in vivo/in vitro.…”

Section: Modelo De Weibullunclassified

Avaliação in vitro da lioequivalência de formulações farmacêuticas

Costa¹

2002

Rev. Bras. Cienc. Farm.

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A avaliação e a comparação da liberação dos fármacos a partir das formas farmacêuticas têm preocupado a indústria farmacêutica INTRODUÇÃOA avaliação e a comparação da liberação dos fármacos a partir das formas farmacêuticas têm preocupado a indústria farmacêutica e as autoridades de registro. Sempre que se produz ou desenvolve uma forma farmacêutica sólida, é necessário garantir que os fármacos sejam liberados de modo adequado. Utilizam-se, hoje em dia, diversos métodos para ajudar a decidir se diferentes formulações liberam os seus fármacos de modo semelhante. Para a realização destes estudos utilizam-se mais freqüentemente os perfis cumulativos de fármaco ao longo do tempo em oposição aos seus perfis diferenciais.Alguns métodos para comparar perfis de liberação foram recentemente propostos (CDER, 1995; Shah, Poli, 1996, Poli et al., 1997Ju, Liaw, 1997;Fassihi, Pillay, 1998;Costa, Lobo, 2001 MÉTODOS ESTATÍSTICOSOs métodos estatísticos utilizados (Tsong et al., 1996;Bartoszynski, et al., 2001) podem ser baseados em testes não-paramétricos, como o teste de Mann-Whitney (Bolton, 1984), o teste de Kolmogorov-Smirnov Z ou o teste do Qui quadrado) ou testes paramétricos (como a

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“…The Weibull model can be successfully applied to most types of dissolution curves and is commonly used in such studies (48,49), in spite of having been the subject of some criticism (50,51). According with this model, the shape parameter (c 2 ) characterizes the curves as either exponential (c 2 =1; case 1), sigmoid, S-shaped, with upward curvature Table V.…”

Section: Model-dependent Methodsmentioning

confidence: 99%

A Comprehensive Development Strategy in Buccal Drug Delivery

2010

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Abstract. This work combines several methods in an integrated strategy to develop a matrix for buccal administration. For this purpose, tablets containing selected mucoadhesive polymers loaded with a model drug (omeprazole), free or in a complexed form with cyclodextrins, and in the absence and presence of alkali agents were subjected to a battery of tests. Mucoadhesion studies, including simple factorial analysis, in vitro release studies with both model-dependent and model-independent analysis, and permeation studies were performed. Mucoadhesive profiles indicated that the presence of the drug decreases the mucoadhesion profile, probably due its hydrophobic character. In tablets loaded with the drug complexed with β-cyclodextrin or methyl-β-cyclodextrin, better results were obtained with the methylated derivative. This effect was attributed to the fact that in the case of β-cyclodextrin, more hydroxyl groups are available to interact with the mucoadhesive polymers, thus decreasing the mucoadhesion performance. The same result was observed in presence of the alkali agent (L-arginine), in this case due to the excessive hydrophilic character of L-arginine. Drug release from tablets was also evaluated, and results suggested that the dissolution profile with best characteristics was observed in the matrix loaded with omeprazole complexed with methyl-β-cyclodextrin in the presence of L-arginine. Several mathematical models were applied to the dissolution curves, indicating that the release of the drug, in free or in complexed state, from the mucoadhesive matrices followed a super case II transport, as established on the basis of the Korsmeyer-Peppas function. The feasibility of drug buccal administration was assessed by permeation experiments on porcine buccal mucosa. The amount of drug permeated from mucoadhesive tablets presented a maximum value for the system containing drug complexed with the methylated cyclodextrin derivative in presence of L-arginine. According to these results, the system containing the selected polymer mixture and the drug complexed with methyl-β-cyclodextrin in presence of L-arginine showed a great potential as a buccal drug delivery formulation, in which a good compromise among mucoadhesion, dissolution, and permeation properties was achieved.

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Physical interpretation of parameters in the Rosin-Rammler-Sperling-Weibull distribution for drug release from controlled release dosage forms

Cited by 37 publications

References 3 publications

A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

Avaliação in vitro da lioequivalência de formulações farmacêuticas

A Comprehensive Development Strategy in Buccal Drug Delivery

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