A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

Dokoumetzidis, Aristides; Papadopoulou, Vasiliki; Macheras, Panos

doi:10.1007/s11095-006-9093-3

Cited by 48 publications

(13 citation statements)

References 41 publications

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“…The Noyes-Whitney equation was developed by some physical chemists at the beginning of the 20th century to characterize of the process of solid dissolution [33, 34]. The equation is

\begin{matrix} \frac{d C}{d t} = \frac{D S}{V h} (C_{s} - C), \end{matrix}

where C is the concentration of a substance in the solution, t is time, dC / dt is the rate of dissolution, C s is the solubility of the substance in the solvent, D is the diffusion coefficient, S is the surface area of the solid, V is the volume of the medium, h is the thickness of the diffusion layer.…”

Section: Methodsmentioning

confidence: 99%

Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

Shi

Wan²,

Zhang

et al. 2014

BioMed Research International

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The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics. It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs. The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic. In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release. The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP). The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied. It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles. The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.

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“…The Noyes-Whitney equation was developed by some physical chemists at the beginning of the 20th century to characterize of the process of solid dissolution [33, 34]. The equation is

\begin{matrix} \frac{d C}{d t} = \frac{D S}{V h} (C_{s} - C), \end{matrix}

Section: Methodsmentioning

confidence: 99%

Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

Shi

Wan²,

Zhang

et al. 2014

BioMed Research International

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“…These results were not unexpected because a more rapid dissolution can occur with greater surface area of drug exposed. On the Noyes-Whitney equation [22] for dissolution of solids, the rate of dissolution is directly proportional to surface area. However, the relative distribution of DQ in the liver and in the blood was dramatically different in that DQ enrichment in the liver was much higher than that in the blood as summarized in Table 4.…”

Section: Discussionmentioning

confidence: 99%

Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Wang

Reyes

et al. 2013

Malaria Research and Treatment

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Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water. In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation. Among many polymers and surfactants tested, polyvinylpyrrolidone 10, a polymer, and L-α-phosphatidylcholine or polysorbate, two surfactants, were chosen as DQ formulation components. The formulation particles were reduced to a mean size between 200 to 400 nm, which was stable in aqueous medium for at least three weeks. Pharmacokinetic (PK) studies showed that compared to DQ microparticle suspension, a nanoparticle formulation orally dosed to mice showed a 14.47-fold increase in area under the curve (AUC) of DQ plasma concentration and a 4.53-fold increase in AUC of DQ liver distribution. WR 299666, a poorly water-soluble compound with antimalarial activity, was also tested and successfully made into nanoparticle formulation without undergoing solid dispersion procedure. We concluded that nanoparticles generated by using appropriate formulation components and sufficient particle size reduction significantly increased the bioavailability of DQ and could potentially turn this antimalarial agent to a therapeutic drug.

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“…where τ 0 represents the time lag onset before swelling, d is related to mechanism, and k W is associated to swelling rate constant [43,44]. The Eq.…”

Section: Studies Of Water Transportmentioning

confidence: 99%

Synthesis and characterization of a pH-responsive poly(ethylene glycol)-based hydrogel: acid degradation, equilibrium swelling, and absorption kinetic characteristics

et al. 2015

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We developed a pH-responsive, hydrogel based on poly(ethylene glycol) (PEG) covalently cross-linked with acrylic acid and N′,N′-dimethylacrylamide along with acidlabile groups. In the hydrogel, PEG plays a role as the key constituent. If its chains break, the polymer networks are destroyed. The pharmacological potential of these hydrogels were demonstrated by determining their water transport profile, modulus of elasticity, and cytotoxicity assay. The hydrogels showed a pseudo-Fickian behavior, a transport mechanism that occurs when the diffusion coefficient changes with the time and the swelling equilibrium is never fully reached. At pH 2, the PEG-richer hydrogels degraded and the scanning electron microscopy (SEM) images illustrated less-defined shapes than at pH 7 and 10. This morphological characteristic results of the hydrogel deconstruction owing to cleavage of ether bonds of the PEG chains unmaking its 3D polymer network. The proposed hydrogels were shown to be compatible to cells, indicating acceptable biocompatibility and an appropriate level of security for use in the biological environments. Furthermore, they showed structural changes in their polymer network in response to pH, which is an important characteristic for stimuli-triggered release of guest molecules.

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A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method: In Vitro Characterization and Tumor Growth Delay in a Breast Cancer Xenograft Model

Cited by 48 publications

References 41 publications

Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity

Synthesis and characterization of a pH-responsive poly(ethylene glycol)-based hydrogel: acid degradation, equilibrium swelling, and absorption kinetic characteristics

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