Experimental and Mathematical Studies on the Drug Release Properties of Aspirin Loaded Chitosan Nanoparticles

Abstract

The study of drug release dynamic is aiming at understanding the process that drugs release in human body and its dynamic characteristics. It is of great significance since these characteristics are closely related to the dose, dosage form, and effect of the drugs. The Noyes-Whitney function is used to represent how the solid material is dissolved into solution, and it is well used in study of drug dynamic. In this research, aspirin (acetylsalicylic acid (ASA)) has been encapsulated with different grades of chitosan (CS) varying in molecular weight (Mw) for the purpose of controlled release. The encapsulation was accomplished by ionic gelation technology based on assembly of positively charged chitosan and negatively charged sodium tripolyphosphate (TPP). The encapsulation efficiency, loading capacity, and drug release behavior of aspirin loaded chitosan nanoparticles (CS-NPs) were studied. It was found that the concentration of TPP and Aspirin, molecular weights of chitosan have important effect on the drug release patterns from chitosan nanoparticles. The results for simulation studies show that the Noyes-Whitney equation can be successfully used to interpret the drug release characteristics reflected by our experimental data.

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

“…A strategy to overcome this drawback is the production of NPs and MPs of pure drug that provide a larger surface area-to-volume ratio and hence a faster drug dissolution rate than the raw material [88]. The effect of the size on the dissolution rate is expressed by the Noyes-Whitney equation [89,90] …”

Magnetic stimulus responsive vancomycin drug delivery system based on chitosan microbeads embedded with magnetic nanoparticles

“…Although these DDS prolong the lifetime and efficacy of drug compared to naked drug, these DDS characteristically have a continuous first‐order elution profile until the drug reserve is exhausted . Slow degrading or nondegrading carriers such as poly‐methylmethacrylate may continue releasing antibiotics at subtherapeutic levels after the drug payload is drained, increasing the risk of antibiotic resistance . Several modifications have been proposed to make such DDS responsive to a variety of stimuli, which would enable on‐demand dosage optimization to actual therapeutic requirement .…”

Low Releasing Mitomycin C Molecule Encapsulated with Chitosan Nanoparticles for Intravesical Installation

“…This disclosed well continued release execution, efficient, and loading capacity [28]. It was seen that the high drug loading resulted in low drug encapsulation efficiency [29].…”