Physical inactivity and cardiovascular risk: baseline observations from men and premenopausal women

Garelnabi, Mahdi; Veledar, Emir; Abramson, Jerome L.; White-Welkley, J. E.; Santanam, Nalini; Weintraub, William S.; Parthasarathy, S.

doi:10.1002/jcla.20368

Cited by 8 publications

(9 citation statements)

References 38 publications

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“…In the available literature there are inconsistencies concerning the association between PA and biomarkers of oxidative stress and inflammation. Some authors [ 31 ] showed an inverse relationship between PA and blood ox-LDL levels, while others failed to document any correlations or significant results were limited to selected populations [ 32 , 33 ]. In our study we have not found an inverse relationship between lifetime LTPA level and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

Kwaśniewska

Kostka

Jegier

et al. 2016

BMC Cardiovasc Disord

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BackgroundThe purpose of the study was to examine the association between leisure-time physical activity (LTPA), cardiovascular biomarkers and atherosclerosis among asymptomatic men with stable LTPA level throughout the 25-year prospective observation.MethodsOut of 101 asymptomatic men prospectively observed for their lifestyle and cardiovascular risk factors, the cohort of 62 individuals (mean age 59.9 years) maintained a stable LTPA level during the 25-year observation. Regular check-ups with the assessment of traditional risk factors, detailed measurements of LTPA level and aerobic capacity were performed since baseline. At the latest follow-up (2011/12) a set of cardiovascular biomarkers was measured using enzyme-linked immunosorbent assay. Subclinical atherosclerosis was assessed by means of coronary artery calcification score and intima-media thickness (IMT). Endothelial function was evaluated by means of the reactive hyperemia index. The studied biomarkers and indices were analyzed in the three cohorts representing stable low-tomoderate (<2050 kcal/week), high (2050-3840 kcal/week) and very high LTPA (>3840 kcal/week).ResultsAt baseline the three cohorts were comparable in terms of age and clinical characteristics. At follow-up, the cohort with stable high LTPA (2050-3840 kcal/week) had significantly lower concentrations of hs-CRP (2.20 ± 1.0 mg/L), oxidized-LDL (68.35 ± 67.7 ng/mL), leptin (4.71 ± 3.07 ng/mL) and irisin (0.47 ± 0.13 μmol/L), and the most favorable indices of atherosclerosis and endothelial function as compared with other groups (p < 0.05). Regular marathon runners had increased concentrations of hsCRP (3.12 ± 1.4 mg/L), oxidized-LDL (249.8 ± 129 ng/ml), Interleukine-6 (3.74 ± 2.4 pg/ml). A positive correlation was observed between hsCRP and IMT (r = 0.301; p < 0.01), and irisin and IMT (r = 0.223; p < 0.05).ConclusionsThe data suggest that stable high LTPA (2050-3840 kcal/week) is associated with the most favorable profile of key cardiovascular biomarkers and indices of atherosclerosis. Lifetime very high LTPA is associated with increased lowgrade inflammation and may, therefore, exert an atherogenic effect.

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Section: Discussionmentioning

confidence: 99%

Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

Kwaśniewska

Kostka

Jegier

et al. 2016

BMC Cardiovasc Disord

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“…Until the 1960s, absolute rest was recommended for patients with autoimmune rheumatic diseases to help treat the disease [5]. However, this recommendation has changed because sedentary behavior is now known to be associated with increases in triglyceride levels, blood pressure, insulin resistance, and cardiovascular risk [6,7]. In this context, exercise training emerged as a nonpharmacological therapy for patients with SAMs, thereby contributing to the restoration of the muscle strength and functional capacity of these individuals and improving their clinical condition.…”

Section: Introductionmentioning

confidence: 99%

Physical exercise among patients with systemic autoimmune myopathies

et al. 2018

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Systemic autoimmune myopathies (SAMs) are a heterogeneous group of rare systemic autoimmune diseases that primarily affect skeletal muscles. Patients with SAMs show progressive skeletal muscle weakness and consequent functional disabilities, low health quality, and sedentary lifestyles. In this context, exercise training emerges as a non-pharmacological therapy to improve muscle strength and function as well as the clinical aspects of these diseases. Because many have feared that physical exercise exacerbates inflammation and consequently worsens the clinical manifestations of SAMs, it is necessary to evaluate the possible benefits and safety of exercise training among these patients. The present study systematically reviews the evidence associated with physical training among patients with SAMs.

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“…Inconsistent results also exist in strength-based training programs with some failing to achieve changes in blood lipid profile in postmenopausal women [ 17 , 18 ] or in adult men [ 16 ], while others have reported benefits [ 19 ]. Additionally, some studies focusing on the effects of the gender in the lipid profile have found significant differences, with women having higher HDL-C, decreased LDL-C, and decreased TG comparing with men [ 20 ]. High-sensitivy C-reactive protein (hs-CRP) is known to be a sensitive marker of inflammation and has also been related to increased risk of vascular disease [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic and strength-based training on metabolic health indicators in older adults

et al. 2010

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BackgroundThe weakening of the cardiovascular system associated with aging could be countered by increasing levels of physical activity and functional fitness. However, inconsistent findings have been found, and the variety of characteristics of exercise used in previous studies may partly explain that inconsistent results.ObjectiveTo investigate the training effect of sixteen weeks of moderate intensity, progressive aerobic and strength-based training on metabolic health of older women and men.MethodsSixty three sedentary individuals (mean (SD) age 76 (8) years) were randomly assigned to control (n = 31) or exercising (n = 32) groups. The training group was separated to aerobic (n = 18) or strength-based (n = 14). Training took place three times a week. Subjects agreed not to change their diet or lifestyle over the experimental period.ResultsExercising group attained after treatment significant differences on body weight, waist circumference, body mass index, diastolic blood pressure, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, total cholesterol/HDL-cholesterol relationship, high sensitivity C-reactive protein, and 6-minute walk distance. The control group only had significant differences on waist circumference.ConclusionThe training programs produced significant benefits on metabolic health indicators of sedentary older women and men.

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Physical inactivity and cardiovascular risk: baseline observations from men and premenopausal women

Abstract: These results suggest intrinsic sex differences between men and women in relation to atherogenic risk.

Cited by 8 publications

References 38 publications

Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

Regular physical activity and cardiovascular biomarkers in prevention of atherosclerosis in men: a 25-year prospective cohort study

Physical exercise among patients with systemic autoimmune myopathies

Effects of aerobic and strength-based training on metabolic health indicators in older adults

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