Physical Findings and Symptoms of Depot Medroxyprogesterone Acetate Use in Adolescent Females

Matson, Stacy; Henderson, K.; McGrath, Gabrielle

doi:10.1016/s1083-3188(97)70039-1

Cited by 53 publications

(24 citation statements)

References 8 publications

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“…17 Weight gain on DMPA significantly impacts both method continuation and restart rates in adolescent girls. 2,3,18 In the current study differences in the amount, character, and risk factors for weight gain were seen between black and white adolescent girls. More research is necessary to explore these differences.…”

Section: Discussionmentioning

confidence: 50%

Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA)

Bonny

Britto

Huang

et al. 2004

Journal of Pediatric and Adolescent Gynecology

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Section: Discussionmentioning

confidence: 50%

Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA)

Bonny

Britto

Huang

et al. 2004

Journal of Pediatric and Adolescent Gynecology

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“…However, little is known about the impact of hormonal contraception on sexual interest among adolescents. In a single, uncontrolled study of 53 adolescent DMPA users, 15% reported decreased sexual desire (Matson, Henderson, & McGrath, 1997).…”

Section: Moodmentioning

confidence: 99%

The Influence of Hormonal Contraception on Mood and Sexual Interest among Adolescents

et al. 2008

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Mood and sexual interest changes are commonly cited reasons for discontinuing hormonal contraceptives. Data, however, are inconsistent and limited to adult users. We examined associations of hormonal contraceptive use with mood and sexual interest among adolescents. We recruited 14-17 year old women primary care clinics and followed them longitudinally for up to 41 months. Participants completed face-to-face interviews quarterly and two 12 week periods of daily diary collection per year. On daily diaries, participants recorded positive mood, negative mood, and sexual interest. We classified 12 week diary periods as "stable OCP use," "non-use," "initiated use," "stopped use," and "DMPA use" based on self-report of oral contraceptive pill (OCP) use and depot medroxyprogesterone acetate (DMPA) use from medical charts. Diary periods were the unit of analysis. Participants could contribute more than one diary period. We analyzed data using linear models with a random intercept and slope across weeks in a diary period, an effect for contraceptive group, and an adjustment for age at the start of a diary period. Mean weekly positive mood was higher in diary periods characterized by stable OCP use, compared to other groups. Mean weekly negative mood was lower in diary periods characterized by stable OCP use and higher in periods characterized by DMPA use. Periods characterized by stable OCP use additionally showed less mood variation than other groups. Changes in mood among adolescent hormonal contraceptive users differed from those anticipated for adult users. Attention to adolescent-specific changes in mood and sexual interest may improve contraceptive adherence.

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“…3 Weight gain is a commonly reported side effect and is cited second only to irregular bleeding as the primary reason for DMPA discontinuation. [4][5][6] Published studies of weight changes among DMPA users are inconsistent. Some studies report no weight changes unique to DMPA users [7][8][9][10] while others find average weight gains as high as 9 kg in 2 y or less.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies report no weight changes unique to DMPA users [7][8][9][10] while others find average weight gains as high as 9 kg in 2 y or less. 6,[11][12][13][14] Most of these studies have used either retrospective designs or did not include controls in the prospective design. Thus, it is difficult to discern if the weight changes, or lack thereof, are due to the potential weight-related dropout bias in the retrospective studies, or to the failure to discriminate DMPA-related weight gain from usual weight gain in uncontrolled prospective studies.…”

Section: Introductionmentioning

confidence: 99%

Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception

et al. 2005

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OBJECTIVE:To compare longitudinal changes in weight, body fat, and ratio of central to peripheral fat mass among first-time depot-medroxyprogesterone acetate (DMPA) users to women using no hormonal contraception, and to evaluate user characteristics associated with that change. DESIGN: Prospective longitudinal study. SUBJECTS: Healthy women, aged 18-35 y, using DMPA for contraception (n ¼ 178) and women using no hormonal contraception (n ¼ 145). MEASUREMENTS: Weight, body fat, and the central distribution of fat, measured at 3-month intervals for 30 months, by electronic scale and dual-energy X-ray absorptiometry (DEXA). The ratio of central to peripheral distribution of body fat was computed by dividing the body fat in the conventional DEXA trunk region of interest (ROI) by the ROI's that encompass the arms, hips and legs. RESULTS: Women using DMPA had a significantly greater increase in all measures of fatness than women using no hormonal method of contraception (Po0. In contrast, weight, fat mass and the ratio of central to peripheral fat mass of control participants remained virtually unchanged over the same time period. Women with higher baseline physical activity levels had a smaller increase in body fat (P ¼ 0.003) and the fat ratio (P ¼ 0.03), but not weight (P ¼ 0.48). No other user characteristics including, smoking, past oral contraceptive use or previous pregnancies predicted change in level of fatness. CONCLUSIONS: This study has demonstrated a change in body composition toward greater fatness and toward a central redistribution of fat among DMPA users as compared to controls and provides important information to be used when counseling women regarding contraceptive methods. Given the potential long-term implication of these changes, further study is recommended to determine whether the gains in fatness are reversed following DMPA discontinuation and to examine the role of progestins in the development and maintenance of obesity.

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Physical Findings and Symptoms of Depot Medroxyprogesterone Acetate Use in Adolescent Females

Cited by 53 publications

References 8 publications

Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA)

Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA)

The Influence of Hormonal Contraception on Mood and Sexual Interest among Adolescents

Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception

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