Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction

Liu, Wei; Wu, Wen; Lin, Guangyong; Cheng, Jiamin; Yu, Shichong

doi:10.3892/mmr.2018.9147

Cited by 18 publications

(19 citation statements)

References 47 publications

(42 reference statements)

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“…Cyclin D1 and CDK4, cell cycle proteins, can form a complex known as Cyclin D1/CDK4 to drive cells through the cell cycle G1/S checkpoint to initiate activation (Kim et al, 2014;Liu et al, 2018). We found that curcumin exposure increased the expression of CDK4 and Cyclin D1 protein significantly, and the expression of CDK4 and Cyclin D1 induced by curcumin was relieved by DAPT treatment, which was consistent with the result of BrdU/Nestin, Notch1, and Hes1 protein.…”

Section: Figsupporting

confidence: 79%

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Li¹,

Han²,

et al. 2019

Cellular Reprogramming

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The abnormal deposition of amyloid-b peptide, a major component of senile plaques, has been reported to be the major cause of neuronal cell death and cognitive impairment in Alzheimer's disease (AD). Adult neurogenesis is related to the amelioration of impaired neurons and cognitive impairment. In the research, we investigated the function of curcumin on endogenous neural stem cells (NSCs) and hippocampal neurogenesis in mice. APP/PS1 transgenic mice as animal models were treated with curcumin, and a significant improvement in learning and memory function was observed. The improvement was associated with a significant increase in the number of new neural stem cells (BrdU + /Nestin +) and newborn neurons (NeuN/kI67 +) in the hippocampal region and decreased the number of apoptotic neurons (TUNEL + and Caspase-3/NeuN +). These results suggested that curcumin activated NSCs proliferation, improved neurogenesis, and ameliorated cognitive impairment of AD mice. Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein. As Notch activity was blocked by the DAPT, the related proteins were downregulated, and the initiating cell proliferation of curcumin was abolished. These results might suggest that the function of curcumin was dependent on Notch signaling pathway.

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Section: Figsupporting

confidence: 79%

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Li¹,

Han²,

et al. 2019

Cellular Reprogramming

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“…The molecular changes evoked by exercise may contribute to a more powerful ADSC action in the brain. Exercise has been shown to improve a wide range of age-related cellular and functional impairments [8].…”

mentioning

confidence: 99%

Neuroprotective Potential of GDF11: Myth or Reality?

Rochette

Malka

2019

IJMS

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In the brain, aging is accompanied by cellular and functional deficiencies that promote vulnerability to neurodegenerative disorders. In blood plasma from young and old animals, various factors such as growth differentiation factor 11 (GDF11), whose levels are elevated in young animals, have been identified. The blood concentrations of these factors appear to be inversely correlated with the age-related decline of neurogenesis. The identification of GDF11 as a “rejuvenating factor” opens up perspectives for the treatment of neurodegenerative diseases. As a pro-neurogenic and pro-angiogenic agent, GDF11 may constitute a basis for novel therapeutic strategies.

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“…Selenium deficiency increases the expression of miR-193b-3p (microRNA-193b-3p) gene, which reduces the gene expression of Mastermind-like protein 1 (MAML1) and thus increases hepatocyte apoptosis (26). In Binte Hossain et al's study, the levels of glutathione and glutathione peroxidase 1 (GPx1) were higher in groups co-administered with cadmium and selenium than in the cadmium-only group.…”

Section: Discussionmentioning

confidence: 97%

Antiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats

Fard

Hoseini

Azarbayjani

et al. 2019

Middle East J Rehabil Health Stud

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Background: Cadmium has negative effects on various tissues of the body while selenium has antioxidant activities. Moreover, the benefits of exercise training for apoptotic factors including caspase-3 and cytochrome c, as well as cyclin D, have been regarded. Objectives: Therefore, the present study aimed to evaluate the anti-apoptotic effects of continuous training and selenium consumption on the liver tissue of cadmium-exposed rats. Methods: In this study, 25 rats were selected and randomly divided into five groups of five rats including: (1) control, (2) selenium consumption, (3) continuous training, (4) continuous training with selenium consumption, and (5) sham. For eight weeks, groups 1 to 4 received peritoneal cadmium (2 mg/kg) daily; groups 2 and 4 received peritoneal selenium (0.23 mg/kg) daily; and groups 3 and 4 performed continuous training three sessions per week. Caspase-3, cytochrome c, and cyclin D were measured at the protein level. Results: Cadmium consumption significantly increased the protein levels of caspase-3 and cytochrome c and decreased cyclin D in rats (P = 0.001). Selenium consumption and continuous training significantly decreased the protein levels of caspase-3 and cytochrome c and increased cyclin D in rats exposed to cadmium (P = 0.001). Continuous training along with selenium consumption had interactive effects on increasing the protein levels of cyclin D in rats exposed to cadmium (P = 0.02). Conclusions: It appears that continuous training and selenium consumption have interactive anti-apoptotic effects in the liver tissue of cadmium-exposed rats.

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Physical exercise promotes proliferation and differentiation of endogenous neural stem cells via ERK in rats with cerebral infarction

Cited by 18 publications

References 47 publications

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Neuroprotective Potential of GDF11: Myth or Reality?

Antiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats

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