Physical exercise program reverts the effects of pinealectomy on the amygdala kindling development

Lacerda, Aline Fabiana Silva de; Janjoppi, Luciana; Lima, Edson Alves de; Amado, Débora; Cavalheiro, Ésper A.; Arida, Ricardo Mário

doi:10.1016/j.brainresbull.2007.06.011

Cited by 12 publications

(3 citation statements)

References 38 publications

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“…Exercise has beneficial effects on epileptogenesis (Arida et al, 1998, 2007, 2010; Silva de Lacerda et al, 2007). Exercise treatment reduced brain susceptibility in the kindling or the pilocarpine model of epilepsy.…”

Section: Role Of Steroid Hormones In Epileptogenesismentioning

confidence: 99%

Role of hormones and neurosteroids in epileptogenesis

Reddy

2013

Front. Cell. Neurosci.

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This article describes the emerging evidence of hormonal influence on epileptogenesis, which is a process whereby a brain becomes progressively epileptic due to an initial precipitating event of diverse origin such as brain injury, stroke, infection, or prolonged seizures. The molecular mechanisms underlying the development of epilepsy are poorly understood. Neuroinflammation and neurodegeneration appear to trigger epileptogenesis. There is an intense search for drugs that truly prevent the development of epilepsy in people at risk. Hormones play an important role in children and adults with epilepsy. Corticosteroids, progesterone, estrogens, and neurosteroids have been shown to affect seizure activity in animal models and in clinical studies. However, the impact of hormones on epileptogenesis has not been investigated widely. There is emerging new evidence that progesterone, neurosteroids, and endogenous hormones may play a role in regulating the epileptogenesis. Corticosterone has excitatory effects and triggers epileptogenesis in animal models. Progesterone has disease-modifying activity in epileptogenic models. The antiepileptogenic effect of progesterone has been attributed to its conversion to neurosteroids, which binds to GABA-A receptors and enhances phasic and tonic inhibition in the brain. Neurosteroids are robust anticonvulsants. There is pilot evidence that neurosteroids may have antiepileptogenic properties. Future studies may generate new insight on the disease-modifying potential of hormonal agents and neurosteroids in epileptogenesis.

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Section: Role Of Steroid Hormones In Epileptogenesismentioning

confidence: 99%

Role of hormones and neurosteroids in epileptogenesis

Reddy

2013

Front. Cell. Neurosci.

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“…Melatonin is also modulated by physical activity (Carr et al., 1981). Considering that melatonin can exert an anticonvulsant action as demonstrated in animal and human studies and the positive effects of physical exercise on epilepsy, a subsequent study examined the influence of physical exercise program on amygdala kindling development in pinealectomized rats (Silva de Lacerda et al., 2007). As observed in a preliminary work evaluating the influence of exercise during the period of epileptogenesis (Arida et al., 1998), acceleration in the kindling development of pinealectomized animals was also reverted by physical exercise.…”

Section: Exercise and Neuroprotectionmentioning

confidence: 99%

Favorable effects of physical activity for recovery in temporal lobe epilepsy

2010

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SUMMARYStrategies that are efficacious for preventing or treating of epilepsy have been extensively used. This review discusses the positive effects of physical exercise program in experimental models of epilepsy, and considerations of the potential application of physical exercise strategy for preventing or treating temporal lobe epilepsy (TLE) are highlighted. Findings from animal studies indicate that exercise can modulate neuronal vulnerability to epileptic insults. Exercise treatment before a precipitating brain insult demonstrates a reduced brain susceptibility in the kindling or the pilocarpine model of epilepsy. In view of the beneficial effect of exercise during the epileptogenesis process, studies analyzed the influence of exercise after the development of chronic epilepsy. Behavioral analysis showed a reduced frequency of seizures during physical exercise program. Metabolic, electrophysiologic, and immunohistochemical studies have confirmed the positive influence of exercise on epilepsy. Taken into account that exercise can exert beneficial actions such as reduction of seizure susceptibility as observed in animal studies, and improvement of quality of life and reduction of anxiety and depression of individuals with epilepsy, physical exercise can be a potential candidate to be integrated with conventional therapy for epilepsy.

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“…Thus, there are favorable reports considering that melatonin is modulated by exercise [73]. To our knowledge, the only study on this topic demonstrated that an exercise program was able to revert the effects of pinealectomy on the amygdala kindling development [74]. From this, the effects of the possible therapeutic use of melatonin associated with regular exercise to ameliorate control of seizures should be considered.…”

Section: Neuroprotective Effects Of Exercise In Epilepsymentioning

confidence: 99%

Experimental and clinical findings from physical exercise as complementary therapy for epilepsy

Arida

Almeida

Cavalheiro

et al. 2013

Epilepsy & Behavior

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Complementary therapies for preventing or treating epilepsy have been extensively used. This review focuses on the positive effects of physical exercise programs observed in clinical studies and experimental models of epilepsy and their significance as a complementary therapy for epilepsy. Information about the antiepileptogenic and neuroprotective effects of exercise is highlighted. Considering that exercise can exert beneficial actions such as reduction of seizure susceptibility, reduction of anxiety and depression, and consequently, improvement of quality of life of individuals with epilepsy, exercise can be a potential candidate as non-pharmacological treatment of epilepsy.

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Physical exercise program reverts the effects of pinealectomy on the amygdala kindling development

Cited by 12 publications

References 38 publications

Role of hormones and neurosteroids in epileptogenesis

Role of hormones and neurosteroids in epileptogenesis

Favorable effects of physical activity for recovery in temporal lobe epilepsy

Experimental and clinical findings from physical exercise as complementary therapy for epilepsy

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