Physical exercise inhibits atherosclerosis development by regulating the expression of neuropeptide Y in apolipoprotein E-deficient mice

Wu, Weiqiang; Song, Peng; Wan, Xiaoqin; Lin, Shu; LinYu, Li; Zhang, Song

doi:10.1016/j.lfs.2019.116896

Cited by 12 publications

(10 citation statements)

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“…Collagen cleavage leads to increased macrophage adhesion and promotes macrophage infiltration. [ 26 ] The expression of three collagen family genes (COL5A1, COL3A1, and COL4A1) was negatively correlated with the expression of NPY, which was found to promote the migration of macrophages in collagen in vitro [ 27 ]. The crosstalk between collagen production and radiotherapy has been studied extensively [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low expression of COL4A1 and COL5A1 was associated with recurrence of vestibular schwannoma; while high expression of NPY was associated with recurrence of vestibular schwannoma. NPY was found to promote the migration of macrophages in collagen in vitro [ 27 ]. Recent studies have shown that these four collagen family genes (COL3A1, COL4A1, COL5A1, and COL15A1) are regulated by macrophages [ 27 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

2021

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Background. The safety of radiotherapy techniques in the treatment of vestibular schwannoma (VS) shows a high rate of tumor control with few side effects. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Further research is still needed on the key genes that determine the sensitivity of VS to radiation therapy. Materials and Methods. Transcriptional microarray data and clinical information data from VS patients were downloaded from GSE141801, and vascular-related genes associated with recurrence after radiation therapy for VS were obtained by combining information from MSigDB. Logistics regression was applied to construct a column line graph prediction model for recurrence status after radiation therapy. Pan-cancer analysis was also performed to investigate the cooccurrence of these genes in tumorigenesis. Results. We identified eight VS recurrence-related genes from the GSE141801 dataset. All of these genes were highly expressed in the VS recurrence samples. Four collagen family genes (COL5A1, COL3A1, COL4A1, and COL15A1) were further screened, and a model was constructed to predict the risk of recurrence of VS. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these four collagen family genes play important roles in a variety of biological functions and cellular pathways. Pan-cancer analysis further revealed that the expression of these genes was significantly heterogeneous across immune phenotypes and significantly associated with immune infiltration. Finally, Neuropeptide Y (NPY) was found to be significantly and negatively correlated with the expression of COL5A1, COL3A1, and COL4A1. Conclusions. Four collagen family genes have been identified as possible predictors of recurrence after radiation therapy for VS. Pan-cancer analysis reveals potential associations between the pathogenesis of VS and other tumorigenic factors. The relevance of NPY to VS was also revealed for the first time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

2021

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“…In the cardiovascular system, Y1R was mainly expressed in macrophages and smooth muscle cells, and has been shown to be involved in immune modulation, vasoconstriction, neointima formation, and the formation of atherosclerosis (Chandrasekharan et al, 2013; Fallgren, Arlock, & Edvinsson, 1993; Li et al, 2011; Wu et al, 2019). We observed that NPY‐induced MMP‐8 expression was also mediated by Y1R in macrophages.…”

Section: Discussionmentioning

confidence: 99%

NPY promotes macrophage migration by upregulating matrix metalloproteinase‐8 expression

Song

Shi

et al. 2020

Journal Cellular Physiology

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“…Hence, the down-regulation of NPY and its receptors can induce anti-atherosclerotic effects. Wu WQ et al found that physical exercise increased plague collagen and smooth muscle cell content and decreased plaque lipid and macrophage content in apolipoprotein E-deficient mice by decreasing the expression of NPY and NPY Y1 receptors in vasculature, suggesting that the down-regulation of NPY and NPY receptors expression in the aorta is critical to the antiatherosclerotic effect (Wu et al, 2019;Figure 3).…”

Section: Atherosclerosismentioning

confidence: 99%

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

Huang

Lin

2021

Front. Cell Dev. Biol.

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Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances. The hypothalamus, and the arcuate nucleus in particular, is the control center for metabolic homeostasis and energy balance. Neuropeptide Y neurons are particularly abundantly expressed in the arcuate of the hypothalamus, where the blood-brain barrier is weak, such as to critically integrate peripheral metabolic signals with the brain center. Herein, focusing on metabolic syndrome, this manuscript aims to provide an overview of the regulatory effects of Neuropeptide Y on metabolic syndrome and discuss clinical intervention strategy perspectives for neurometabolic disease.

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Physical exercise inhibits atherosclerosis development by regulating the expression of neuropeptide Y in apolipoprotein E-deficient mice

Cited by 12 publications

References 36 publications

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

NPY promotes macrophage migration by upregulating matrix metalloproteinase‐8 expression

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

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