NPY promotes macrophage migration by upregulating matrix metalloproteinase‐8 expression

Wu, Weiqiang; Song, Peng; Shi, Yan‐Chuan; Li, Linyu; Zhang, Song; Lin, Shu

doi:10.1002/jcp.29973

Cited by 18 publications

(15 citation statements)

References 28 publications

(58 reference statements)

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“…CFU-M is further differentiated into mononucleated osteoclasts and subsequently fused to multinucleated osteoclasts, then fully matured upon a cognate interaction with osteoblasts (53). Wu et al reported that NPY greatly increased the amount of RAW264.7 cell (mouse leukemic monocyte macrophage cell line) migration at different concentrations, and this effect can be diminished by the Y1R antagonist and ERK1/2 inhibitor, which suggest that NPY promotes osteoclast migration through Y1R and ERK1/2 activation (22). NPY has also been shown to exhibit an inhibitory effect on isoprenaline-induced osteoclastogenesis by suppressing RANKL expression in mouse bone marrow cells (54).…”

Section: Npy and Bone Resorptionmentioning

confidence: 99%

“…Y1R has also been reported to be involved in many physiological activities, such as mitogenic activity, macrophage migration, and pulpal development ( 17 , 21 , 22 ). In bone tissue, Y1R is highly expressed in BMSCs, osteoblast, osteocyte, monocyte/macrophage, and osteoclast ( 2 ), prompting it to play a regulatory role in the local area.…”

Section: Neuropeptide Y and Its Receptorsmentioning

confidence: 99%

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The Role of NPY in the Regulation of Bone Metabolism

Chen

Zhang

2022

Front. Endocrinol.

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Bone diseases are the leading causes of disability and severely compromised quality of life. Neuropeptide Y (NPY) is a multifunctional neuropeptide that participates in various physiological and pathological processes and exists in both the nerve system and bone tissue. In bone tissue, it actively participates in bone metabolism and disease progression through its receptors. Previous studies have focused on the opposite effects of NPY on bone formation and resorption through paracrine modes. In this review, we present a brief overview of the progress made in this research field in recent times in order to provide reference for further understanding the regulatory mechanism of bone physiology and pathological metabolism.

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Section: Npy and Bone Resorptionmentioning

confidence: 99%

Section: Neuropeptide Y and Its Receptorsmentioning

confidence: 99%

The Role of NPY in the Regulation of Bone Metabolism

Chen

Zhang

2022

Front. Endocrinol.

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“…M2-type macrophages in VS are associated with angiogenesis and tumor growth [ 25 ]. Collagen cleavage leads to increased macrophage adhesion and promotes macrophage infiltration.…”

Section: Discussionmentioning

confidence: 99%

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

2021

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Background. The safety of radiotherapy techniques in the treatment of vestibular schwannoma (VS) shows a high rate of tumor control with few side effects. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Further research is still needed on the key genes that determine the sensitivity of VS to radiation therapy. Materials and Methods. Transcriptional microarray data and clinical information data from VS patients were downloaded from GSE141801, and vascular-related genes associated with recurrence after radiation therapy for VS were obtained by combining information from MSigDB. Logistics regression was applied to construct a column line graph prediction model for recurrence status after radiation therapy. Pan-cancer analysis was also performed to investigate the cooccurrence of these genes in tumorigenesis. Results. We identified eight VS recurrence-related genes from the GSE141801 dataset. All of these genes were highly expressed in the VS recurrence samples. Four collagen family genes (COL5A1, COL3A1, COL4A1, and COL15A1) were further screened, and a model was constructed to predict the risk of recurrence of VS. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these four collagen family genes play important roles in a variety of biological functions and cellular pathways. Pan-cancer analysis further revealed that the expression of these genes was significantly heterogeneous across immune phenotypes and significantly associated with immune infiltration. Finally, Neuropeptide Y (NPY) was found to be significantly and negatively correlated with the expression of COL5A1, COL3A1, and COL4A1. Conclusions. Four collagen family genes have been identified as possible predictors of recurrence after radiation therapy for VS. Pan-cancer analysis reveals potential associations between the pathogenesis of VS and other tumorigenic factors. The relevance of NPY to VS was also revealed for the first time.

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“…Alternatively, PD98059, an ERK1/2 inhibitor, reduced NPY-induced MMP-8 expression. Additionally, NPY promoted macrophage migration in vitro [ 43 ]. Park et al demonstrated that NPY induces macrophage PI3K/Akt/mTOR/eIL4E signalling pathway activation, which results in the production of transforming growth factor (TGF), leading to the upregulation of TGF-β expression and secretion by macrophages [ 44 ].…”

Section: Npy and The Inflammatory Microenvironmentmentioning

confidence: 99%

Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

et al. 2021

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Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interaction with immune cells, brain-derived trophic factor (BDNF), and angiogenesis promotion to maintain body homeostasis. Additionally, NPY has great potential for therapeutic applications against various diseases, especially as an adjuvant therapy for stem cells. In this review, we discuss the research progress regarding NPY, as well as the current evidence for the regulation of NPY in each microenvironment, and provide prospects for further research on related diseases.

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NPY promotes macrophage migration by upregulating matrix metalloproteinase‐8 expression

Cited by 18 publications

References 28 publications

The Role of NPY in the Regulation of Bone Metabolism

The Role of NPY in the Regulation of Bone Metabolism

Collagen Family Genes Associated with Risk of Recurrence after Radiation Therapy for Vestibular Schwannoma and Pan-Cancer Analysis

Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

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