Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

Zhang, Yan; Liu, Chu-Yun; Chen, Wei-can; Shi, Yan‐Chuan; Wang, Cong-Mei; Lin, Shu; He, Hefan

doi:10.1186/s13578-021-00657-7

Cited by 29 publications

(29 citation statements)

References 139 publications

(164 reference statements)

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“…Overexpression of NPY stimulates angiogenesis in blood vessels by stimulating the release of VEGF and enhancing the process of mitogenesis or vasoconstriction in endothelial cells, resulting in decreased coronary blood flow and cardia output [ 85 ], endothelial dysfunction, increased peripheral resistance, and the formation of local vascular stenosis. On the other hand, the release of VEGF does contribute to plaque rupture and hemorrhage [ 87 ]. Table 2 summarizes the effect of BPA on cardiovascular disease.…”

Section: Resultsmentioning

confidence: 99%

“…On the contrary, NPY possesses the characteristics to stop the effect of anti-angiogenic agents in cardiac such as endostatin and angiostatin [ 88 ] thereby preventing the revascularization of ischemic tissue [ 86 ] and the thickening of the intimal tissue in the heart [ 87 ]. Furthermore, NPY increases the release of dipeptidyl peptidase 4 in heart tissue under specific clinical conditions.…”

Section: Resultsmentioning

confidence: 99%

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Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Naomi

Yazid

Bahari

et al. 2022

IJMS

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BPA is one of the most common endocrine disruptors that is widely being manufactured daily nationwide. Although scientific evidence supports claims of negative effects of BPA on humans, there is also evidence suggesting that a low level of BPA is safe. However, numerous in vivo trials contraindicate with this claim and there is a high possibility of BPA exposure could lead to obesity. It has been speculated that this does not stop with the exposed subjects only, but may also cause transgenerational effects. Direct disruption of endocrine regulation, neuroimmune and signaling pathways, as well as gut microbiata, has been identified to be interrupted by BPA exposure, leading to overweight or obesity. In these instances, cardiovascular complications are one of the primary notable clinical signs. In regard to this claim, this review paper discusses the role of BPA on obesity in the perspective of endocrine disruptions and possible cardiovascular complications that may arise due to BPA. Thus, the aim of this review is to outline the changes in gut microbiota and neuroimmune or signaling mechanisms involved in obesity in relation to BPA. To identify potentially relevant articles, a depth search was done on the databases Nature, PubMed, Wiley Online Library, and Medline & Ovid from the past 5 years. According to Boolean operator guideline, selected keywords such as (1) BPA OR environmental chemical AND fat OR LDL OR obese AND transgenerational effects or phenocopy (2) Endocrine disruptors OR chemical AND lipodystrophy AND phenocopy (3) Lipid profile OR weight changes AND cardiovascular effect (4) BPA AND neuroimmune OR gene signaling, were used as search terms. Upon screening, 11 articles were finalized to be further reviewed and data extraction tables containing information on (1) the type of animal model (2) duration and dosage of BPA exposure (3) changes in the lipid profile or weight (4) genes, signaling mechanism, or any neuroimmune signal involved, and (5) transgenerational effects were created. In toto, the study indicates there are high chances of BPA exposure affecting lipid profile and gene associated with lipolysis, leading to obesity. Therefore, this scoping review recapitulates the possible effects of BPA that may lead to obesity with the evidence of current in vivo trials. The biomarkers, safety concerns, recommended dosage, and the impact of COVID-19 on BPA are also briefly described.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Naomi

Yazid

Bahari

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The use of (non-) faradaic EIS and chronoamperometry confirmed the platform's usability to measure NPY in concept tests even at 10 pg/m. NPY is a 36-amino acid polypeptide that, despite its expression throughout the central and peripheral nervous systems, has been associated with several microenvironments as the inflammatory one [ 117 ]. Immune cells such as macrophages express NPY receptors that have been associated with immune regulation.…”

Section: Wearable Epidermal Biosensors (Webs) Design and Mode Of Func...mentioning

confidence: 99%

Wearable electrochemical biosensors to measure biomarkers with complex blood-to-sweat partition such as proteins and hormones

Pérez

Orozco

2022

Microchim Acta

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Smart electronic devices based on micro-controllers, also referred to as fashion electronics, have raised wearable technology. These devices may process physiological information to facilitate the wearer's immediate biofeedback in close contact with the body surface. Standard market wearable devices detect observable features as gestures or skin conductivity. In contrast, the technology based on electrochemical biosensors requires a biomarker in close contact with both a biorecognition element and an electrode surface, where electron transfer phenomena occur. The noninvasiveness is pivotal for wearable technology; thus, one of the most common target tissues for real-time monitoring is the skin. Noninvasive biosensors formats may not be available for all analytes, such as several proteins and hormones, especially when devices are installed cutaneously to measure in the sweat. Processes like cutaneous transcytosis, the paracellular cell–cell unions, or even reuptake highly regulate the solutes content of the sweat. This review discusses recent advances on wearable devices based on electrochemical biosensors for biomarkers with a complex blood-to-sweat partition like proteins and some hormones, considering the commented release regulation mechanisms to the sweat. It highlights the challenges of wearable epidermal biosensors (WEBs) design and the possible solutions. Finally, it charts the path of future developments in the WEBs arena in converging/emerging digital technologies. Graphical abstract

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“…NPY can also exert pro-inflammatory effects on macrophages by promoting the synthesis of pro-inflammatory cytokines [ 462 ]. NPY significantly increases the expression of TNF-α, C-reactive protein, and monocyte chemoattractant protein 1 (MCP1) in macrophages during inflammation [ 471 ]. However, NPY also exerts anti-inflammatory effects by stimulating the release of macrophage anti-inflammatory cytokines IL-10 and IL-1RA and transforming macrophages into the M2-like phenotype [ 445 ].…”

Section: Neuropeptides and Their Receptors In The Corneamentioning

confidence: 99%

Immunomodulatory Role of Neuropeptides in the Cornea

2022

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The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their immunomodulatory functions in the healthy and diseased cornea. Much remains to be known regarding the details of neuropeptide signaling and how it contributes to pathophysiology, which is likely due to complex interactions among neuropeptides, receptor isoform-specific signaling events, and the inflammatory microenvironment in disease. However, progress in this area has led to an increase in studies that have begun modulating neuropeptide activity for the treatment of corneal diseases with promising results, necessitating the need for a comprehensive review of the literature. This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface, alterations in disease settings, and the possible therapeutic potential of targeting these systems.

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Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

Cited by 29 publications

References 139 publications

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Wearable electrochemical biosensors to measure biomarkers with complex blood-to-sweat partition such as proteins and hormones

Immunomodulatory Role of Neuropeptides in the Cornea

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