Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

Revilla, Susana; Suñol, Cristina; García-Mesa, Yoelvis; Giménez-Llort, Lydia; Sanfeliu, Coral; Cristòfol, Rosa

doi:10.1016/j.neuropharm.2014.01.037

Cited by 118 publications

(68 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Parachikova et al (2008) found no effect on amyloid pathology in 15-19 month old Tg2576 mice housed with a running wheel for three weeks. Furthermore, housing of one month old triple transgenic mice with a running wheel for six months had no effect on A␤42 or p-Tau expression (Revilla et al, 2014). This however contrasts with the data presented in a recent study from Cho et al (2015).…”

Section: Ad Pathologycontrasting

confidence: 98%

“…Finally, in the APP23 mouse model of amyloidosis, ten days of voluntary wheel running reduced cell survival in six month old mice but increased neuronal differentiation (Mirochnic et al, 2009). Furthermore, several studies have reported increased expression of synaptic plasticity-related proteins, key growth factors and transcription factors that are associated with exercise-mediated effects on hippocampal neurogenesis such as synaptophysin and postsynaptic density protein 95 (PSD-95) (Cho et al, 2015;Revilla et al, 2014), BDNF (Cho et al, 2015;Um et al, 2011), nerve growth factor (NGF) (Um et al, 2011), glialderived neurotrophic factor (GDNF) (Revilla et al, 2014), cAMP response element-binding protein (CREB) (Um et al, 2011) and SIRT1 (Revilla et al, 2014). From the few studies to date that have examined exercise-induced effects on hippocampal neurogenesis in AD mouse models, it is clear that neurogenic deficits can be effectively modulated by this intervention.…”

Section: Hippocampal Neurogenesismentioning

confidence: 99%

See 1 more Smart Citation

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Ryan

Kelly

2016

Ageing Research Reviews

View full text Add to dashboard Cite

a b s t r a c tIt is now well established, at least in animal models, that exercise elicits potent pro-cognitive and proneurogenic effects. Alzheimer's disease (AD) is one of the leading causes of dementia and represents one of the greatest burdens on healthcare systems worldwide, with no effective treatment for the disease to date. Exercise presents a promising non-pharmacological option to potentially delay the onset of or slow down the progression of AD. Exercise interventions in mouse models of AD have been explored and have been found to reduce amyloid pathology and improve cognitive function. More recent studies have expanded the research question by investigating potential pro-neurogenic and anti-inflammatory effects of exercise. In this review we summarise studies that have examined exercise-mediated effects on AD pathology, cognitive function, hippocampal neurogenesis and neuroinflammation in transgenic mouse models of AD. Furthermore, we attempt to identify the optimum exercise conditions required to elicit the greatest benefits, taking into account age and pathology of the model, as well as type and duration of exercise.© 2016 Elsevier B.V. All rights reserved. Please cite this article in press as: Ryan, S.M., Kelly, Á.M., Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease. Ageing Res. Rev. (2016), http://dx

show abstract

Section: Ad Pathologycontrasting

confidence: 98%

Section: Hippocampal Neurogenesismentioning

confidence: 99%

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Ryan

Kelly

2016

Ageing Research Reviews

View full text Add to dashboard Cite

show abstract

“…Recently, [109], have reported that GDNF was down regulated in 3xTgAD mice (a transgenic strain of mice) and 6 months of voluntary exercise was capable of reverse this effect. Furthermore, it has reported that 10-month-old 3xTg-AD mice subjected to 6 months of overexpressing GDNF (recombinant lentiviral vectors), showed improvement in the learning and memory.…”

Section: Gdnf and Alzheimer's Diseasementioning

confidence: 99%

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Budni¹,

Bellettini-Santos²,

Mina³

et al. 2015

Aging and disease

331

188

View full text Add to dashboard Cite

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cellderived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.

show abstract

“…The NAD-dependent deacetylase, involved in oxidative stress and aging processes, increases in antioxidant capacity following moderate/prolonged exercise in aged rat hearts (Ferrara et al 2008;Lai et al 2014;Lin et al 2014); physical exercise promotes further the downstream pathways of SIRT1 (Suchankova et al 2009). Revilla et al (2014) demonstrated beneficial effects of 6 months of voluntary exercise on synaptic plasticity in 7-month-old 39Tg-AD mice, a transgenic model of dementia and aging (Sterniczuk et al 2010). In these mice, down-regulated synaptic proteins, synaptophysin and PSD-95, and the neuroprotective proteins, GDNF and SIRT1, were restored by 6-month running wheel intervention.…”

Section: Exercise Alleviation Of Apoptosis Underlying Schizophreniamentioning

confidence: 93%

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer

Kostrzewa

2015

Neurotox Res

View full text Add to dashboard Cite

Schizophrenia spectrum disorders are characterized by symptom profiles consisting of positive and negative symptoms, cognitive impairment, and a plethora of genetic, epigenetic, and phenotypic biomarkers. Assorted animal models of these disorders and clinical neurodevelopmental indicators have implicated neurodegeneration as an element in the underlying pathophysiology. Physical exercise or activity regimes--whether aerobic, resistance, or endurance--ameliorate regional brain and functional deficits not only in affected individuals but also in animal models of the disorder. Cognitive deficits, often linked to regional deficits, were alleviated by exercise, as were quality-of-life, independent of disorder staging and risk level. Apoptotic processes intricate to the etiopathogenesis of schizophrenia were likewise attenuated by physical exercise. There is also evidence of manifest benefits endowed by physical exercise in preserving telomere length and integrity. Not least, exercise improves overall health and quality-of-life. The notion of scaffolding as the outcome of physical exercise implies the "buttressing" of regional network circuits, neurocognitive domains, anti-inflammatory defenses, maintenance of telomeric integrity, and neuro-reparative and regenerative processes.

show abstract

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

Cited by 118 publications

References 65 publications

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Contact Info

Product

Resources

About