Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer, Trevor; Kostrzewa, Richard M.

doi:10.1007/s12640-015-9543-y

Cited by 16 publications

(11 citation statements)

References 165 publications

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“…Studies have demonstrated the efficacy of aerobic exercise in treating the cognitive and biochemical deficits found in SCH patients (Archer and Kostrzewa, 2015). In addition to enhanced expression of insulin-like growth factor (IGF)-1 and BDNF (Kim et al, 2014;Kuo et al, 2013), people suffering from SCH who led an active lifestyle had lower levels of serum CRP when compared to the sedentary control population (Stubbs et al, 2015).…”

Section: Anti-inflammatory Effects Of Physical Activity and Exercise mentioning

confidence: 99%

“…Experimental and epidemiological studies have demonstrated that living a healthy and physically active lifestyle reduces the risk (Barnes and Yaffe, 2011;Scarmeas et al, 2009;Zou et al, 2015) and severity of neurological diseases (Archer and Kostrzewa, 2015;Canning et al, 2015;Erickson et al, 2012;Eyre and Baune, 2012;Frazzitta et al, 2015;Frazzitta et al, 2014;Liu et al, 2013;Radak et al, 2007;Radak et al, 2013;Suijo et al, 2013;Uc et al, 2014;Yu et al, 2014). However, the cellular and molecular mechanisms responsible for these beneficial effects of PA have not been established.…”

Section: Summary and Hypothesesmentioning

confidence: 99%

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Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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Section: Anti-inflammatory Effects Of Physical Activity and Exercise mentioning

confidence: 99%

Section: Summary and Hypothesesmentioning

confidence: 99%

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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“…resulting in subjective or objective binge eating episodes for example, often induced by the failure of restriction to dietary rules [2]. These notions support the essential over-evaluation of weight and shape and that this cognitive mind-set in its turn influences the attempts at eating restraint [3]. It has been observed also that low individual self-esteem exerts a general influence on over-evaluation of weight and shape [4].…”

Section: Editorialmentioning

confidence: 86%

Exercise in Anorexia Nervosa: Complexity of Pathology and Health

Archer¹

2016

Clin Exp Psychol

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EditorialAnorexia nervosa (AN) condition presents a serious and potentially life-threatening eating disorder characterized by episodes of self-starvation and excessive weight loss that may be accompanied by excessive exercise [1]. The notion that the condition offers a dysfunctional system of individuals' self-evaluation of self-worth, where self-worth as determined from perceived body shape and weight and the degree to which they consider themselves to be in control of their own shape and weight. The control need and necessity for specific body shape and weight appears to drive the pathologic dietary restraint and the consequent operationalization of these tendencies into various behavioural expressions and dietary rules that may either lead to success, e.g. outcome weight loss, or fail in implementation, e.g. resulting in subjective or objective binge eating episodes for example, often induced by the failure of restriction to dietary rules [2]. These notions support the essential over-evaluation of weight and shape and that this cognitive mind-set in its turn influences the attempts at eating restraint [3]. It has been observed also that low individual self-esteem exerts a general influence on over-evaluation of weight and shape [4]. Since low self-esteem in its turn has been shown to be associated with higher negative affect as measured with Positive Affect and Negative Affect Schedule [5,6], it appears conceivable that individuals afflicted with the psychopathology condition experience less positive and more negative affect, as a consequence of low self-esteem. Physical exercise influences cognitive, emotional, learning and neurophysiological domains, both directly and indirect, thereby rendering it essential that this noninvasive, non-pharmacological intervention ought to form a part of children's and adolescents' long-term health programs [7,8].Introducing exercise regimes has been found to be beneficial to the health and well-being of individuals, both under laboratory and clinical conditions and has been demonstrated using a variety of health guidelines and biomarkers [9]. Physical, bodily, activities enhancing or maintaining physical fitness mobilize the engagement of regular and frequent exercise thereby ensuring physical fitness to the exclusion of agents associated with health problems, e.g. pro-inflammatory cytokines and cortisol. Taking into account, the large proportion of individuals with more-or-less sedentary preoccupations, physical exercise presents uniquely one of the most potent health-promoting lifestyles available by rendering positive outcomes for both neurologic and psychiatric conditions [10][11][12][13][14][15]. It is beneficial also within domains defined by neurocognitive capacity, quality-of-life, postural and motor efficacy and affective status [16][17][18]. Generally, exercise has been defined as a planned, structured physical activity with the purpose of improving one or more aspects of physical fitness and functional capacity [19]. Health status may be estimated by the level of...

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“…Regular exercise aimed at patients with schizophrenia can help to reduce body mass index, improve psychiatric symptoms, and lead to feelings of accomplishment and therefore provide an impact on quality of life. (19)(20)(21) In this sense, managers and professionals who work with this population should support the need for planning and implementation of initiatives to promote and encourage this practice in the routine of health services, including seeking of intersectoral partnerships.…”

Section: Discussionmentioning

confidence: 99%

Esquizofrenia refratária: qualidade de vida e fatores associados

et al. 2016

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Objective: To analyze the quality of life of people with refractory schizophrenia using clozapine, and its associated factors. Methods: A cross-sectional study, conducted in the extended western region of Minas Gerais, which included patients with refractory schizophrenia using the antipsychotic, clozapine. For the measurement of quality of life, the Quality of Life Scale was used, specific for patients with schizophrenia. Univariate and multivariate analyses were performed. Results: A total of 72 patients with a mean age of 42.9 years was part of the study. The overall score of the Quality of Life Scale indicated compromised quality of life, with a greater impairment in the social network domain (median = 2.36). The logistic regression analysis showed factors associated with a better quality of life. Conclusion: Low quality of life in patients with refractory schizophrenia was found. Physical activity, family income over three times the minimum wage, and having children were associated with a better quality of life. ResumoObjetivo: Analisar a qualidade de vida de pessoas com esquizofrenia refratária em uso de clozapina e seus fatores associados. Métodos: Estudo de delineamento transversal, realizado na Região Ampliada Oeste de Minas Gerais, que incluiu pacientes com esquizofrenia refratária em uso do antipsicótico clozapina. Para a mensuração da qualidade de vida, foi utilizada a escala Quality of Life Scale, específica para pacientes com esquizofrenia. Foram realizadas análise univariada e multivariada. Resultados: Participaram 72 pacientes, com média de idade de 42,9 anos. O escore global da Quality of Life Scale indicou qualidade de vida comprometida, com maior prejuízo no domínio rede social (mediana = 2,36). A análise de regressão logística apontou fatores associados a uma melhor qualidade de vida. Conclusão: Evidenciou-se uma baixa qualidade de vida dos pacientes com esquizofrenia refratária. Praticar atividade física, renda familiar acima de três salários mínimos e possuir filhos foram associados à melhor qualidade de vida.

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Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Cited by 16 publications

References 165 publications

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Exercise in Anorexia Nervosa: Complexity of Pathology and Health

Esquizofrenia refratária: qualidade de vida e fatores associados

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