Physical exercise for dermatomyositis and polymyositis: a systematic review and meta-analysis

Silva, Beatriz Iwamoto Sercundes Leite da; Santos, Beatriz Roberto Jorge Dos; Carneiro, Julia Alves; Silva, Fernanda Maximo Fonseca E; Souza, Jean Marcos de

doi:10.1007/s10067-022-06281-1

Cited by 2 publications

(1 citation statement)

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“…Physical exercise and/or physiotherapy are recommended throughout all phases of the disease and have been shown to be beneficial and safe, with the potential for improving cardiorespiratory function and muscle strength 27 , 28 .…”

Section: Clinical Discussionmentioning

confidence: 99%

Clinically amyopathic dermatomyositis associated with cutaneous ulcerations: a case-based review

De Jesus,

De Souza

2024

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Dermatomyositis (DM) is an autoimmune myopathy primarily affecting both muscles and skin. When muscle weakness is not clinically apparent, but characteristic skin lesions are present, the condition is referred to as clinically amyopathic dermatomyositis (CADM). Case Presentation: We present the case of a 52-year-old female with a typical DM rash, interstitial pneumonia, and multiple skin ulcers. The skin biopsy was consistent with DM, and there were no signs of muscle involvement. Myositis-related and myositis-specific autoantibodies were also negative. Significant improvement was not observed until the patient received successive monthly pulses of methylprednisolone and the introduction of methotrexate. This treatment regimen allowed for the complete tapering of prednisone and resulted in sustained disease control. Clinical Discussion: In addition to the case presentation, a narrative literature review was conducted using the MEDLINE database, and an evidence-based treatment flowchart is proposed. CADM is a subtype of DM, related to higher incidences of interstitial lung disease, skin vasculopathy and malignancy. When ulcers or interstitial pneumonia are present, treatment should be early and aggressive. Active screening for neoplasms is recommended, particularly within the first 5 years. Conclusion: We presented a case of seronegative CADM featuring skin vasculopathy, successfully treated with consecutive methylprednisolone pulses. Our literature review emphasized the importance of focused CADM management trials, highlighting the need for further research.

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Section: Clinical Discussionmentioning

confidence: 99%