Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity

Kayacan, Yıldırım; Ghojebeigloo, Babak Elmi; Cerit, Günay; Kocacan, Suleyman Emre; Ayyıldız, Mustafa

doi:10.1016/j.yebeh.2020.107403

Cited by 7 publications

(14 citation statements)

References 24 publications

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“…A reduction of electrographic seizure activity in exercised animals was found in eight studies (29-32, 34-36, 40) and one did not find significant alterations following exercise (33). Specifically, physical exercise reduced the spike/wave frequency in five studies (29-32, 36) and did not induce a significant alteration spike/wave frequency in another investigation (33). Concerning the spike/wave amplitude, four investigations reported a reduction (31,34,35,40), and six did not find significant alterations (32)(33)(34)(35)(36)40) following exercise.…”

Section: Electrophysiological Analysismentioning

confidence: 95%

“…Nine studies investigated electrophysiological analysis following chemoconvulsants. A reduction of electrographic seizure activity in exercised animals was found in eight studies (29-32, 34-36, 40) and one did not find significant alterations following exercise (33). Specifically, physical exercise reduced the spike/wave frequency in five studies (29-32, 36) and did not induce a significant alteration spike/wave frequency in another investigation (33).…”

Section: Electrophysiological Analysismentioning

confidence: 96%

“…Only studies that used exercise intervention before SE induction were included. Six studies used a treadmill (28)(29)(30)(31)(32)(33), five studies used swimming (34)(35)(36)(37)(38), two studies used a running wheel (39,40), and two studies used combined exercise: one applied treadmill and swimming (41), and the other used running wheel and treadmill (42). The total duration of exercise ranged between 21 and 90 days.…”

Section: Included Studiesmentioning

confidence: 99%

“…The frequency ranged from five to seven times a week, and two studies did not report session frequency and duration (39,40). Among the chemoconvulsants used in the selected studies, two used pentylenetetrazol (34,35), five used penicillin (30)(31)(32)(33)36), four used kainic acid (37)(38)(39)(40), three pilocarpine (28,41,42), and one homocysteine (29). See details in Table 1.…”

Section: Included Studiesmentioning

confidence: 99%

“…From 15 included studies, 13 demonstrated that physical exercise reduced seizure susceptibility induced by different chemoconvulsants such as homocysteine thiolactone (HCT), pentylenetetrazole (PTZ), penicillin, kainite, or pilocarpine (28)(29)(30)(31)(32)(34)(35)(36)(37)(38)(39)(40)(41) and two studies revealed no significant difference in seizure susceptibility between the exercise and control groups (33,42), which suggests a potential protective effect of exercise against seizure susceptibility.…”

Section: Effects Of Interventionsmentioning

confidence: 99%

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The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

et al. 2021

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Background: Clinical and pre-clinical studies indicate a reduction in seizure frequency as well as a decrease in susceptibility to subsequently evoked seizures after physical exercise programs. In contrast to the influence of exercise after epilepsy previously established, various studies have been conducted attempting to investigate whether physical activity reduces brain susceptibility to seizures or prevents epilepsy. We report a systematic review and meta-analysis of different animal models that addressed the impact of previous physical exercise programs to reduce seizure susceptibility.Methods: We included animal model (rats and mice) studies before brain insult that reported physical exercise programs compared with other interventions (sham, control, or naïve). We excluded studies that investigated animal models after brain insult, associated with supplement nutrition or drugs, that did not address epilepsy or seizure susceptibility, ex vivo studies, in vitro studies, studies in humans, or in silico studies. Electronic searches were performed in the MEDLINE (PubMed), Web of Science (WOS), Scopus, PsycINFO, Scientific Electronic Library Online (SciELO) databases, and gray literature, without restrictions to the year or language of publication. We used SYRCLE's risk of bias tool and CAMARADES checklist for study quality. We performed a synthesis of results for different types of exercise and susceptibility to seizures by random-effects meta-analysis.Results: Fifteen studies were included in the final analysis (543 animals), 13 of them used male animals, and Wistar rats were the most commonly studied species used in the studies (355 animals). The chemoconvulsants used in the selected studies were pentylenetetrazol, penicillin, kainic acid, pilocarpine, and homocysteine. We assessed the impact of study design characteristics and the reporting of mitigations to reduce the risk of bias. We calculated a standardized mean difference effect size for each comparison and performed a random-effects meta-analysis. The meta-analysis included behavioral analysis (latency to seizure onset, n = 6 and intensity of motor signals, n = 3) and electrophysiological analysis (spikes/min, n = 4, and amplitude, n = 6). The overall effect size observed in physical exercise compared to controls for latency to seizure onset was −130.98 [95% CI: −203.47, −58.49] (seconds) and the intensity of motor signals was −0.40 [95% CI: −1.19, 0.40] (on a scale from 0 to 5). The largest effects were observed in electrophysiological analysis for spikes/min with −26.96 [95% CI: −39.56, −14.36], and for spike amplitude (μV) with −282.64 [95% CI: −466.81, −98.47].Discussion:Limitations of evidence. A higher number of animal models should be employed for analyzing the influence of exerciseon seizure susceptibility. The high heterogeneity in our meta-analysis is attributable to various factors, including the number of animals used in each study and the limited number of similar studies. Interpretation. Studies selected in this systematic review and meta-analysis suggest that previous physical exercise programs can reduce some of the main features related to seizure susceptibility [latency seizure onset, spikes/min, and spike amplitude (μV)] induced by the administration of different chemoconvulsants.Systematic Review Registration: PROSPERO, identifier CRD42021251949; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251949.

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Section: Electrophysiological Analysismentioning

confidence: 95%

Section: Electrophysiological Analysismentioning

confidence: 96%

Section: Included Studiesmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

Section: Effects Of Interventionsmentioning

confidence: 99%

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The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

et al. 2021

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Auswirkungen körperlicher Aktivität auf Status epilepticus im Tiermodell

2023

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Zusammenfassung Hintergrund Die Evidenz zum Einfluss körperlicher Aktivität (kA) auf die Anfallsfrequenz in Humanstudien ist niedrig. Ziel Literaturbasierte narrative Darstellung des Einflusses von kA auf Status epilepticus (SE) im Tiermodell. Material und Methode Auf Basis einer systematischen Literaturrecherche wurden kontrollierte, sportliche Interventionsstudien im Tiermodell für alle Anfallsmodelle sowie Belastungsformen und Modalitäten eingeschlossen, die den Einfluss auf klinische Endpunkte wie Anfallsfrequenz, Latenz und Intensität von Anfällen oder epilepsietypische Aktivität im EEG untersuchten. Ergebnisse Es wurden 33 Studien mit 37 Interventionen (Ausdauer‑, Schwimm- oder Krafttrainings verschiedener Intensität, Dauer und Frequenz) eingeschlossen, im Rahmen derer eine Trainings- mit einer Kontrollgruppe verglichen wurde. Die untersuchten Endpunkte waren sehr heterogen und beinhalteten unter anderem epilepsietypische Aktivität im EEG, Latenz bis zum ersten Anfall, Stärke der Symptome oder Anfallsfrequenz. Insgesamt zeigte sich nach 20 Interventionen ein positiver Effekt, nach 9 Interventionen ein heterogener Effekt (positiv oder ausbleibend), nach 6 Interventionen ein ausbleibender Effekt und nach 1 Intervention ein positiver und ein negativer Effekt bezüglich der untersuchten klinischen Endpunkte. Schlussfolgerung Im Tiermodell scheint kA keinen relevanten negativen Einfluss auf anfallsassoziierte Endpunkte zu haben und wirkt sich tendenziell in den meisten Fällen, z. B. hinsichtlich der Anfallsfrequenz, positiv aus. Diese Ergebnisse sollten zur Untersuchung des Einflusses von kA auf die Anfallsfrequenz in Humanstudien motivieren.

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Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats

et al. 2021

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Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity

Cited by 7 publications

References 24 publications

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

The Potential Role of Previous Physical Exercise Program to Reduce Seizure Susceptibility: A Systematic Review and Meta-Analysis of Animal Studies

Auswirkungen körperlicher Aktivität auf Status epilepticus im Tiermodell

Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats

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