Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats

pour, Mitra Barzroodi; Bayat, Mohammad; Navazesh, Azam; Soleimani, Mansoureh; Karimzadeh, Fariba

doi:10.1007/s11064-021-03349-3

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…While several studies have revealed potential therapeutic effects of exercise with epilepsy [7] , [9] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , our understanding of the fundamental molecular mechanisms remains limited. DNA methylation is a universal epigenetic mechanism responsible for regulating gene expression in multiple diseases [44] , [45] , with strong evidence of its role in epilepsy [10] , [12] .…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy

Sint Jago,

Bahabry,

Schreiber

et al. 2024

Epilepsy & Behavior Reports

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Section: Discussionmentioning

confidence: 99%

Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy

Sint Jago,

Bahabry,

Schreiber

et al. 2024

Epilepsy & Behavior Reports

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“…A second study also demonstrated that 100 mg/kg of CBD exerted a significant antiepileptic effect in rodent models of Epilepsy ( 20 ). CBZ could relieve seizures with CBZ 75 mg/kg injected ( 21 ).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing

Gong

Liu

et al. 2022

Front. Nutr.

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AimsEpilepsy is a neurological disease occurring worldwide. Alterations in the gut microbial composition may be involved in the development of Epilepsy. The study aimed to investigate the effects of cannabidiol (CBD) on gut microbiota and the metabolic profile of epileptic rats.Materials and methods and resultsA temporal lobe epilepsy rat model was established using Li-pilocarpine. CBD increased the incubation period and reduced the epileptic state in rats. Compared to epileptic rats, the M1/M2 ratio of microglia in the CBD group was significantly decreased. The expression of IL-1β, IL-6, and TNF-α in the CBD group decreased, while IL-10, IL-4, and TGF-β1 increased. 16S rDNA sequencing revealed that the ANOSIM index differed significantly between the groups. At the genus level, Helicobacter, Prevotellaceae_UCG-001, and Ruminococcaceae_UCG-005 were significantly reduced in the model group. CBD intervention attenuated the intervention effects of Li-pilocarpine. Roseburia, Eubacterium_xylanophilum_group, and Ruminococcus_2 were strongly positively correlated with proinflammatory cytokine levels. CBD reversed dysregulated metabolites, including glycerophosphocholine and 4-ethylbenzoic acid.ConclusionCBD could alleviate the dysbiosis of gut microbiota and metabolic disorders of epileptic rats. CBD attenuated Epilepsy in rats might be related to gut microbial abundance and metabolite levels.Significance and impact of studyThe study may provide a reliable scientific clue to explore the regulatory pathway of CBD in alleviating Epilepsy.

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“…Another possible DTx "active ingredient" for epilepsy management is physical activity [304][305][306][307]. Preclinical studies show that physical exercise can reduce epileptic seizures [308][309][310] and enhance the efficacy of ASMs, such as carbamazepine and valproate [311,312]. Translational aspects of physical exercises in epilepsy suggest such benefits as antiepileptogenesis and neuroprotection [313,314].…”

Section: Epilepsymentioning

confidence: 99%

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

Biskupiak,

Ha,

Rohaj

et al. 2024

JCM

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Limitations of pharmaceutical drugs and biologics for chronic diseases (e.g., medication non-adherence, adverse effects, toxicity, or inadequate efficacy) can be mitigated by mobile medical apps, known as digital therapeutics (DTx). Authorization of adjunct DTx by the US Food and Drug Administration and draft guidelines on “prescription drug use-related software” illustrate opportunities to create drug + digital combination therapies, ultimately leading towards drug–device combination products (DTx has a status of medical devices). Digital interventions (mobile, web-based, virtual reality, and video game applications) demonstrate clinically meaningful benefits for people living with Alzheimer’s disease, dementia, rheumatoid arthritis, cancer, chronic pain, epilepsy, depression, and anxiety. In the respective animal disease models, preclinical studies on environmental enrichment and other non-pharmacological modalities (physical activity, social interactions, learning, and music) as surrogates for DTx “active ingredients” also show improved outcomes. In this narrative review, we discuss how drug + digital combination therapies can impact translational research, drug discovery and development, generic drug repurposing, and gene therapies. Market-driven incentives to create drug–device combination products are illustrated by Humira® (adalimumab) facing a “patent-cliff” competition with cheaper and more effective biosimilars seamlessly integrated with DTx. In conclusion, pharma and biotech companies, patients, and healthcare professionals will benefit from accelerating integration of digital interventions with pharmacotherapies.

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Exercise Improved the Anti-Epileptic Effect of Carbamazepine through GABA Enhancement in Epileptic Rats

Cited by 7 publications

References 57 publications

Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy

Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy

Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing

Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases

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