Physical condition, nutritional status, fatigue, and quality of life in oncological out-patients

Schulz, Karl‐Heinz; Patra, Stefan; Spielmann, Hannah; Klapdor, Silke; Schlüter, Kathrin; Eckert, Sandra van

doi:10.1177/2050312117743674

Cited by 19 publications

(14 citation statements)

References 54 publications

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“…Participants of group G2 seem to have superior cell quantity, quality, and vitality, expressed by the strong correlation between PhA and BCM (r=0.732; p=0.007). Other studies have confirmed this finding, suggesting that PhA can be used as a predictor of cell quality and quantity of ICW [51]. Reductions in PhA may be explained by the reduction in fat-free mass and the increase in ECW, which expresses the state of cell hydration and the integrity of the cell wall [52].…”

Section: Discussionmentioning

confidence: 61%

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

Martins

Oliveira

Brito

et al. 2021

Physiology & Behavior

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Accurate predictive tools are key factors for cancer care. Phase angle (PhA) has been proposed as a marker of cellular health, particularly of cell-membrane integrity. Cutoff values have been proposed, including for cancer survivors. This study aimed to assess the usefulness of the proposed PhA cutoff, as a marker of bioelectrical impedance analysis (BIA) assessed health-status, and functional capacity in breast cancer (BC) survivors. This cross-sectional study included 25 women (50.6 ± 8.6 yrs) survivors of BC, divided into two groups according to the PhA reference value of 5.6 et al. 2008). BIA-assessed health status parameters included: extracellular water (ECW), intracellular water (ICW), total body water (TBW), PhA, body mass, fat-free mass, muscle mass, body cell mass (BCM). Four functional tests were performed: 30 s chair-stand test, timed up and go test, ball throw test and 6-minute walking test. Results showed G2 had lower ECW/ICW ratio (p=0.001; ES=1.2), ECW/BCM ratio (p=0.001; ES=3.2) and ECW/TBW ratio (p=0.001; ES=4.8). There was no difference in functional capacity between groups. The results of the present study show that patients with higher PhA values have a higher ICW values and preservation in the ECW/ICW ratio, suggesting it's a better cell membrane quality and integrity. Relation of both PhA and cell membrane integrity with functional capacity warrants further research.

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Section: Discussionmentioning

confidence: 61%

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

Martins

Oliveira

Brito

et al. 2021

Physiology & Behavior

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“…Fatigue can occur as an acute or chronic state, most often observed in specific medical disorders such as cancer, heart failure, and stroke [30,31]. Impaired nutritional status has frequently been linked to fatigue in cancer patients [32,33]. Stobäus et al moreover showed that recent protein intake in cancer patients is associated with higher fatigue, implying that not only nutritional status but also acute dietary intake has an effect on fatigue [34].…”

Section: Discussionmentioning

confidence: 99%

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

et al. 2019

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Although malnutrition is frequent in the old, little is known about its association with fatigue. We evaluated the relation of self-reported severe weight loss with fatigue and the predictors for fatigue in old patients at hospital discharge. Severe weight loss was defined according to involuntary weight loss ≥5% in the last three months. We determined fatigue with the validated Brief Fatigue Inventory questionnaire. The regression analyses were adjusted for age, sex, number of comorbidities, medications/day, and BMI. Of 424 patients aged between 61 and 98 y, 34.1% had severe weight loss. Fatigue was higher in patients with severe weight loss (3.7 ± 2.3 vs. 3.2 ± 2.3 points, p = 0.021). In a multinomial regression model, weight loss was independently associated with higher risk for moderate fatigue (OR:1.172, CI:1.026–1.338, p = 0.019) and with increased risk for severe fatigue (OR:1.209, CI:1.047–1.395, p = 0.010) together with the number of medications/day (OR:1.220, CI:1.023-1.455, p = 0.027). In a binary regression model, severe weight loss predicted moderate-to-severe fatigue in the study population (OR:1.651, CI:1.052-2.590, p = 0.029). In summary, patients with self-reported severe weight loss at hospital discharge exhibited higher fatigue levels and severe weight loss was an independent predictor of moderate and severe fatigue, placing these patients at risk for impaired outcome in the post-hospital period.

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“…ESPEN strongly recommended PhA as a prognostic nutritional measure [24, 25]. The possibility of predicting the occurrence or exacerbation of a given disease is emphasized by many researchers around the world [8, 9, 26, 27]. Hui et al in their research phase angle retained its prognostic significance in the context of many known prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

“…Low phase angle score is considered as an indicator of impaired cellular membrane integrity and also indicates the shift of body water from intracellular to extracellular compartments [7]. PhA is an important prognostic factor in numerous disease entities [8, 9]. The European Society for Clinical Nutrition and Metabolism (ESPEN) recommends the assessment of PhA as a prognostic measure of nutrition and a reliable prognostic marker.…”

Section: Introductionmentioning

confidence: 99%

Body composition and phase angle as an indicator of nutritional status in children with juvenile idiopathic arthritis

et al. 2018

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BackgroundJuvenile idiopathic arthritis (JIA) is the most common chronic, systemic autoimmune connective tissue disease diagnosed in children and adolescents. An important aspect of monitoring of children with JIA is a precise assessment of the nutritional status to identify children and adolescents at risk of malnutrition. The aim of the study was to assess the body composition and phase angle in children diagnosed with JIA in comparison to age and sex matched healthy children since there are scarce reports in paediatric patients.MethodsA total of 46 children and adolescents aged 4–18 years, with JIA were included in the cross-sectional study. Controls were selected from the group of healthy children and adolescents. Children with diagnosed JIA and healthy children were strictly matched for age and gender. In both groups BIA with phase angle calculation was performed.ResultsPhase angle score was significantly lower in the study group compared to control group (5.45 ± 0.64 vs. 5.85 ± 0.80, p = 0.010). Also lower percentage of body cell mass (50.63 ± 3.46 vs. 52.70 ± 4.06, p = 0.010) and muscle mass (46.02 ± 6.32 vs. 49.53 ± 6.67, p = 0.005) were revealed. In the analysis of subtypes of JIA we found significant differences between children and adolescents with polyarthritis compared to control group, while no significant differences were found between patients with oligoarthritis and control group.ConclusionsThe obtained results indicate a higher risk of malnutrition in children and adolescents with JIA compared to healthy peers, predominantly in patients with polyarthritis.

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Physical condition, nutritional status, fatigue, and quality of life in oncological out-patients

Cited by 19 publications

References 54 publications

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

Body composition and phase angle as an indicator of nutritional status in children with juvenile idiopathic arthritis

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