“…This caused much interest in different adhesives that could overcome such problems. Different materials including chlorhexidine,[ 3 ] fluorine-containing agents,[ 4 ] Proseal,[ 5 ] amorphous calcium phosphate,[ 6 ] iodide quaternary ammonium methacryloxy silicate,[ 7 ] nanoparticles included in the adhesive (i.e., nanofillers, silver, TiO 2 , SiO 2 , hydroxyapatite, fluorapatite, fluorohydroxyapatite) and bracket surfaces coated with a thin film of nitrogen-doped TiO 2 ,[ 8 ] triazine, and niobium pentoxide phosphate[ 9 ] have been added to orthodontic adhesives to decrease decalcification around bonded brackets. Incorporation of these materials suffers from some limitations such as compromising mechanical properties and limitation of active component release,[ 3 4 ] discoloration and esthetic problems,[ 10 ] and reduction of bond strength,[ 11 ] so neither of these materials are accepted as the best.…”